The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-4329
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2025
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Bautin A.E.

Almazov National Medical Research Center

Afanasyeva K.Yu.

Almazov National Medical Research Center

Marichev A.O.

Almazov National Medical Research Centre

Radovskiy A.M.

Almazov National Medical Research Center

Barygin E.K.

Almazov National Medical Research Center

Gusenova A.K.

Almazov National Medical Research Center

Chomakhashvili I.G.

Almazov National Medical Research Center

Badalyan N.V.

Almazov National Medical Research Center

Zhuravleva M.S.

Almazov National Medical Research Center

Pozhidaeva A.M.

Almazov National Medical Research Center

Impact of inhaled gas compound on nitric dioxide release in a model of nitric oxide inhalation therapy (experimental study)

Authors:

Bautin A.E., Afanasyeva K.Yu., Marichev A.O., Radovskiy A.M., Barygin E.K., Gusenova A.K., Chomakhashvili I.G., Badalyan N.V., Zhuravleva M.S., Pozhidaeva A.M.

More about the authors

Journal: Russian Journal of Anesthesiology and Reanimatology. 2024;(1): 23‑30

DOI: 10.17116/anaesthesiology202401123

Read: 2488 times

Download PDF (RU)
Download PDF
Contact the author
Table of contents

IMPACT OF INHALED GAS COMPOUND ON NITRIC DIOXIDE RELEASE IN A MODEL OF NITRIC OXIDE INHALATION THERAPY (EXPERIMENTAL STUDY)
IMPACT OF INHALED GAS COMPOUND ON NITRIC DIOXIDE RELEASE IN A MODEL OF NITRIC OXIDE INHALATION THERAPY (EXPERIMENTAL STUDY)

To cite this article:

Bautin AE, Afanasyeva KYu, Marichev AO, et al. . Impact of inhaled gas compound on nitric dioxide release in a model of nitric oxide inhalation therapy (experimental study). Russian Journal of Anesthesiology and Reanimatology. 2024;(1):23‑30. (In Russ., In Engl.)
https://doi.org/10.17116/anaesthesiology202401123

МСФ на ЯМ
Использование инфографики авторами научных работ
Close metadata
Recommended articles:
Prevention of acute kidney injury in cardiac surgery. Russian Journal of Anesthesiology and Reanimatology. 2025;(2):83-89
Gastrointestinal tract protection with nitric oxide in aortic arch surgery: a randomized study. Russian Journal of Anesthesiology and Reanimatology. 2025;(4):13-20
The significance of exogenous nitrate and nitrite of plant origin for vascular health. Russian Journal of Preventive Medi­cine. 2024;(11):141-146
Biomarkers of athe­rothrombotic and cardioembolic subtypes of acute ischemic stroke. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(12-2):20-26
Biomarkers in tear fluid in uveitis. Russian Annals of Ophthalmology. 2025;(4):88-95
Antioxidant therapy for the correction of nitrosative stress in inflammatory diseases of the nasal cavity. Russian Rhinology. 2025;(3):191-196
Abstract:

BACKGROUND

Toxic effects of nitric dioxide (NO2) released under nitric oxide (NO) inhalation limit the application of nitric oxide high-dose therapy of clinical conditions accompanied by increased pulmonary vascular resistance.

OBJECTIVE

To identify the combinations of safe NO and O2 concentrations in inhaled gas compound for nitric dioxide release in a model of NO insufflation through the «Tianox» apparatus into respiratory circuit.

MATERIAL AND METHODS

The study was performed on an experimental model. There were 360 measurements of NO2 content in 72 various combinations of NO and O2.

RESULTS

NO2 release depended on NO and O2 content in gas mixture. Multivariate regression analysis confirmed this fact. NO2 concentration <2 ppm was recognized as a safe value. ROC-analysis confirmed predictive ability of NO and O2 regarding toxic NO2 concentrations. In case of inhalation therapy through the «Tianox» apparatus with any NO concentrations (10—80 ppm), O2 content in gas mixture within 21—30% was safe. NO concentration <50 ppm is safe at any O2 content in gas mixture (21—100%).

CONCLUSION

There is a fundamentally new source of NO in the Tianox device (synthesis from atmospheric air). We obtained data on possible safe combinations of inhaled O2 and NO regarding NO2 release for effective clinical use of this device.

Keywords:

nitric oxide
nitric dioxide
“Tianox” device
pulmonary vascular resistance
experimental stand

Authors:

Bautin A.E.

Almazov National Medical Research Center

Afanasyeva K.Yu.

Almazov National Medical Research Center

Marichev A.O.

Almazov National Medical Research Centre

Radovskiy A.M.

Almazov National Medical Research Center

Barygin E.K.

Almazov National Medical Research Center

Gusenova A.K.

Almazov National Medical Research Center

Chomakhashvili I.G.

Almazov National Medical Research Center

Badalyan N.V.

Almazov National Medical Research Center

Zhuravleva M.S.

Almazov National Medical Research Center

Pozhidaeva A.M.

Almazov National Medical Research Center

Received:

03.08.2023

Accepted:

22.09.2023

Close metadata

References:

  1. Bautin AE, Osovskikh VV. Acute right ventricular failure. Vestnik anesteziologii i reanimatologii. 2018;15(5):74-86. (In Russ.). https://doi.org/10.21292/2078-5658-2018-15-5-74-86
  2. Avdeev SN, Barbarash OL, Bautin AE, Volkov AV, Veselova TN, Galyavich AS, Goncharova NS, Gorbachevsky SV, Danilov NM, Eremenko AA, Martynyuk TV, Moiseeva OM, Saidova MA, Sergienko VB, Simakova MA, Stukalova OV, Chazova IE, Chernyavsky AM, Shalaev SV, Shmalts AA, Tsareva NA. 2020 Clinical practice guidelines for Pulmonary hypertension, including chronic thromboembolic pulmonary hypertension. Rossijskij kardiologicheskij zhurnal. 2021;26(12):198-267. (In Russ.). https://doi.org/10.15829/1560-4071-2021-4683
  3. George I, Xydas S, Topkara VK, Ferdinando C, Barnwell EC, Gableman L, Sladen RN, Naka Y, Oz MC. Clinical indication for use and outcomes after inhaled nitric oxide therapy. The Annals of Thoracic Surgery. 2006;82(6):2161-2169. https://doi.org/10.1016/j.athoracsur.2006.06.081
  4. Germann P, Braschi A, Della Rocca G, Dinh-Xuan AT, Falke K, Frostell C, Gustafsson LE, Hervé P, Jolliet P, Kaisers U, Litvan H, Macrae DJ, Maggiorini M, Marczin N, Mueller B, Payen D, Ranucci M, Schranz D, Zimmermann R, Ullrich R. Inhaled nitric oxide therapy in adults: European expert recommendations. Intensive Care Medicine. 2005;31(8):1029-1041. https://doi.org/10.1007/s00134-005-2675-4
  5. Petit PC, Fine DH, Vásquez GB, Gamero L, Slaughter MS, Dasse KA. The Pathophysiology of Nitrogen Dioxide during Inhaled Nitric Oxide Therapy. ASAIO Journal. 2017;63(1):7-13.  https://doi.org/10.1097/MAT.0000000000000425
  6. Centers for Disease Control (CDC). NIOSH recommendations for occupational safety and health standards, 1988. MMWR Supplements. 1988 Aug;37 (Suppl 7):1-29. 
  7. Renaudin MN. Le monoxyde d’azote. Paris; 1994:1-8F. (In French).
  8. Lindberg L, Rydgren G. Production of nitrogen dioxide during nitric oxide therapy using the Servo Ventilator 300 during volume-controlled ventilation. Acta Anaesthesiologica Scandinavica. 1999;43(3):289-294.  https://doi.org/10.1034/j.1399-6576.1999.430308.x
  9. Buranov SN, Karelin VI, Selemir VD, Shirshin AS. Apparatus for inhalation NO-therapy. Pribory i tekhnika eksperimenta. 2019;5:158-159. (In Russ.). https://doi.org/10.1134/S0032816219040037
  10. Blasina F, Vaamonde L, Silvera F, Solla G, Abin-Carriquiry JA, Gutiérrez C, Beltramo P, Garcia-Gabay I, Martell M. Efficacy and safety of a novel nitric oxide generator for the treatment of neonatal pulmonary hypertension: Experimental and clinical studies. Pulmonary Pharmacology and Therapeutics. 2015;54:68-76.  https://doi.org/10.1016/j.pupt.2018.12.002
  11. Bautin AE, Selemir VD, Shafikova AI, Afanasyeva KYu, Kurskova ES, Etin VL, Marichev AO, Tashkhanov DM, Rubinchik VE, Kasherininov IYu, Morozov KA, Nikiforov VG, Biktasheva LZ, Akhimov PS, Buranov SN, Karelin VI, Shirshin AS, Valueva YuV, Pichugin VV. Evaluation of the clinical efficacy and safety of nitric oxide synthesized from room air in the postoperative period of cardiac surgery. Translyatsionnaya meditsina. 2021;8(1):38-50. (In Russ.). https://doi.org/10.18705/2311-4495-2021-8-1-38-50
  12. Bautin AE, Selemir VD, Nurgalieva AI, Morozov KA, Nikiforov VG, Biktasheva LZ, Afanasyeva KYu, Marichev AO, Tashkhanov DM, Karpova LI, Ivanov IYu, Akhimov PS, Buranov SN, Karelin VI, Shirshin AS, Valueva YuV, Domnin SE, Pichugin VV. Inhalation therapy with nitric oxide obtained by synthesis from atmospheric air in the postoperative period of cardiac surgery in children: a single-center retrospective cohort study. Annals of Critical Care. 2021;(3):98-107. (In Russ.). https://doi.org/10.21320/1818-474X-2021-3-98-107
  13. Treacy JC, Daniels F. Kinetic study of the oxidation of nitric oxide with oxygen in the pressure range 1 to 20 Mm. Journal of the American Chemical Society. 1955;77: 2033-2036.
  14. Glasson WA, Tuesday CS. The atmospheric thermal oxidation of nitric oxide. Journal of the American Chemical Society. 1963;85:2901-2904.
  15. Nishimura M, Hess D, Kacmarek RM, Ritz R, Hurford WE. Nitrogen dioxide production during mechanical ventilation with nitric oxide in adults. Effects of ventilator internal volume, air versus nitrogen dilution, minute ventilation, and inspired oxygen fraction. Anesthesiology. 1995;82:1246-1254.
  16. Schedin U, Frostell CG, Gustafsson LE. Formation of nitrogen dioxide from nitric oxide and their measurement in clinically relevant circumstances. British Journal of Anaesthesia. 1999;82(2):182-192.  https://doi.org/10.1093/bja/82.2.182
  17. Lindberg L, Rydgren G. Production of nitrogen dioxide in a delivery system for inhalation of nitric oxide: A new equation for calculation. British Journal of Anaesthesia. 1998;80(2):213-217.  https://doi.org/10.1093/bja/80.2.213
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.