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Grebenchikov O.A.

Federal Research and Clinical Center for Intensive Care and Rehabilitation

Kulabukhov V.V.

Sklifosovsky Research Institute for Emergency Care

Shabanov A.K.

Sklifosovsky Research Institute for Emergency Care

Ignatenko O.V.

Yudin Moscow City Clinical Hospital;
Federal Scientific and Clinical Center of Intensive Care and Rehabilitation

Antonova V.V.

Federal Scientific and Clinical Center for Resuscitation and Rehabilitation;
Sklifosovsky Research Institute for Emergency Care

Cherpakov R.A.

Federal Scientific and Clinical Center for Resuscitation and Rehabilitation;
Sklifosovsky Research Institute for Emergency Care

Redkin I.V.

Federal Scientific and Clinical Center for Resuscitation and Rehabilitation

Boeva E.A.

Federal Scientific and Clinical Center for Resuscitation and Rehabilitation

Kuzovlev A.N.

Federal Scientific and Clinical Center of Intensive Care and Rehabilitation

Prospects of inhalation sedation in intensive care

Authors:

Grebenchikov O.A., Kulabukhov V.V., Shabanov A.K., Ignatenko O.V., Antonova V.V., Cherpakov R.A., Redkin I.V., Boeva E.A., Kuzovlev A.N.

More about the authors

Journal: Russian Journal of Anesthesiology and Reanimatology. 2022;(3): 84‑94

DOI: 10.17116/anaesthesiology202203184

Read: 3202 times

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Table of contents

PROSPECTS OF INHALATION SEDATION IN INTENSIVE CARE
PROSPECTS OF INHALATION SEDATION IN INTENSIVE CARE

To cite this article:

Grebenchikov OA, Kulabukhov VV, Shabanov AK, et al. . Prospects of inhalation sedation in intensive care. Russian Journal of Anesthesiology and Reanimatology. 2022;(3):84‑94. (In Russ.)
https://doi.org/10.17116/anaesthesiology202203184

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Использование инфографики авторами научных работ
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Abstract:

This review is devoted to analysis of available literature data on the prospects and safety of prolonged inhalation sedation in intensive care unit using the AnaConDa inhalation sedation device. Prolonged inhalation sedation in ICU patients contributes to early activation and rehabilitation due to favorable controllability, reduces duration of mechanical ventilation. This simple and safe technique has neuroprotective, cardioprotective, anti-inflammatory, anticonvulsant, broncholythic and many other positive effects. It can be concluded that researchers have yet to establish the advantages or disadvantages of inhalation anesthetic sedation versus intravenous superficial sedation in routine clinical practice.

Keywords:

sedation
inhalation anesthetics
sevoflurane
AnaConDa
organ protection
anesthesiology and intensive care

Authors:

Grebenchikov O.A.

Federal Research and Clinical Center for Intensive Care and Rehabilitation

Kulabukhov V.V.

Sklifosovsky Research Institute for Emergency Care

Shabanov A.K.

Sklifosovsky Research Institute for Emergency Care

Ignatenko O.V.

Yudin Moscow City Clinical Hospital;
Federal Scientific and Clinical Center of Intensive Care and Rehabilitation

Antonova V.V.

Federal Scientific and Clinical Center for Resuscitation and Rehabilitation;
Sklifosovsky Research Institute for Emergency Care

Cherpakov R.A.

Federal Scientific and Clinical Center for Resuscitation and Rehabilitation;
Sklifosovsky Research Institute for Emergency Care

Redkin I.V.

Federal Scientific and Clinical Center for Resuscitation and Rehabilitation

Boeva E.A.

Federal Scientific and Clinical Center for Resuscitation and Rehabilitation

Kuzovlev A.N.

Federal Scientific and Clinical Center of Intensive Care and Rehabilitation

Received:

12.07.2021

Accepted:

15.12.2021

Close metadata

References:

  1. Potievskaya VI, Zabolotskikh IB, Gridchik IE, Gritsan AI, Eremenko AA, Kozlov IA, Lebedinskii KM, Levit AL, Mazurok VA, Molchanov IV, Nikolaenko EHM. Sedation of patients in intensive care units. Anesteziologiya i reanimatologiya. 2020;(5):7-22. (In Russ.). https://doi.org/10.17116/anaesthesiology20200517
  2. Likhvantsev VV, Yadgarov MYA, Di Piazza M, Kadantseva KK. Inhalation vs total intravenous anesthesia: where is the pendulum now? (meta-analysis and review). General reanimatology. 2020;16(6):91-104. (In Russ.). https://doi.org/10.15360/1813-9779-2020-6-91-104
  3. Aliev VA, Yavorovskii AG, Shaposhnikov AA, Loriya IZH, Vetsheva MS. Comparative evaluation of modern inhaled anesthetics at carotid endarterectomy. General reanimatology. 2019;15(1):27-38. (In Russ.). https://doi.org/10.15360/1813-9779-2019-1-27-38
  4. Shafiekhani M, Mirjalili M, Vazin A. Psychotropic drug therapy in patients in the intensive care unit — usage, adverse effects, and drug interactions: a review. Ther Clin Risk Manag. 2018;14:1799-1812. https://doi.org/10.2147/TCRM.S176079
  5. Kozlov IA. Modern approaches to sedation in intensive care units. Meditsinskii alfavit. 2013;1(8):22-32. (In Russ.).
  6. Walsh TS, Kydonaki K, Antonelli J, et al. Rationale, design and methodology of a trial evaluating three strategies designed to improve sedation quality in intensive care units (DESIST study). BMJ Open. 2016;6(3):e010148. https://doi.org/10.1136/bmjopen-2015-010148
  7. Zhang H, Yuan J, Chen Q, et al. Development and validation of a predictive score for ICU delirium in critically ill patients. BMC Anesthesiol. 2021;21(1):37.  https://doi.org/10.1186/s12871-021-01259-z
  8. Yang J, Zhou Y, Kang Y, et al. Risk Factors of Delirium in Sequential Sedation Patients in Intensive Care Units. Biomed Res Int. 2017;2017:3539872. https://doi.org/10.1155/2017/35398722
  9. Aggarwal J, Lustrino J, Stephens J, Morgenstern D, Tang WY. Cost-Minimization Analysis of Dexmedetomidine Compared to Other Sedatives for Short-Term Sedation During Mechanical Ventilation in the United States [published correction appears in Clinicoecon Outcomes Res. 2020;12:619-623]. Clinicoecon Outcomes Res. 2020;12:389-397.  https://doi.org/10.2147/CEOR.S242994
  10. Hu AM, Zhong XX, Li Z, Zhang ZJ, Li HP. Comparative Effectiveness of Midazolam, Propofol, and Dexmedetomidine in Patients With or at Risk for Acute Respiratory Distress Syndrome: A Propensity Score-Matched Cohort Study. Front Pharmacol. 2021;12:614465. https://doi.org/10.3389/fphar.2021.614465
  11. Diasamidze KE, Mishin GM, Chitorelidze MA, Abadzhyan MF. Ketamine. A 50-year modern history. Russian Journal of Anaesthesiology and Reanimatology. 2021;(5):86-92. (In Russ.). https://doi.org/10.17116/anaesthesiology202105186
  12. Likhvantsev VV. Prakticheskoe rukovodstvo po anesteziologii. M.: OOO Meditsinskoe informatsionnoe agentstvo; 2011. (In Russ.).
  13. Hou D, Liu B, Zhang J, Wang Q, Zheng W. Evaluation of the Efficacy and Safety of Short-Course Deep Sedation Therapy for the Treatment of Intracerebral Hemorrhage After Surgery: A Non-Randomized Control Study. Med Sci Monit. 2016;22:2670-2678. https://doi.org/10.12659/msm.899787
  14. Parke TJ, Stevens JE, Rice AS, et al. Metabolic acidosis and fatal myocardial failure after propofol infusion in children: five case reports. BMJ. 1992;305(6854):613-616.  https://doi.org/10.1136/bmj.305.6854.613
  15. Bray RJ. Propofol infusion syndrome in children. Paediatric Anaesthesia. 1998;8(6):491-499.  https://doi.org/10.1046/j.1460-9592.1998.00282.x
  16. Hemphill S, McMenamin L, Bellamy MC, Hopkins PM. Propofol infusion syndrome: a structured literature review and analysis of published case reports. Br J Anaesth. 2019;122(4):448-459.  https://doi.org/10.1016/j.bja.2018.12.025
  17. Hanna JP, Ramundo ML. Rhabdomyolysis and hypoxia associated with prolonged propofol infusion in children. Neurology. 1998;50(1):301-303.  https://doi.org/10.1212/wnl.50.1.301
  18. Roberts RJ, Jeffrey F Barletta JF, Fong JF, Schumaker G, Kuper PJ, et al. Incidence of propofol-related infusion syndrome in critically ill adults: a prospective, multicenter study. Critical Care. 2009;13:169.  https://doi.org/10.1186/cc8145
  19. Fong JJ, Sylvia L, Ruthazer R, Schumaker G, Kcomt M, Devlin JW: Predictors of mortality in patients with suspected propofol infusion syndrome. Crit Care. 2008;36:2281-2287. https://doi.org/10.1097/CCM.0b013e318180c1eb
  20. Vasile B, Rasulo F, Candiani A, Latronico N: The pathophysiology of propofol infusion syndrome: a simple name for a complex syndrome. Intensive Care Med. 2003;29:1417-1425. https://doi.org/10.1007/s00134-003-1905-x
  21. Ahlen K, Buckley CJ, Goodale DB, Pulsford AH: The ‘propofol infusion syndrome’: the facts, their interpretation and implications for patient care. Eur J Anaesthesiol. 2006;23:990-998.  https://doi.org/10.1017/S0265021506001281
  22. Shankar V, Churchwell KB, Deshpande JK. Isoflurane therapy for severe refractory status asthmaticus in children. Intensive Care Med. 2006;32:927-933.  https://doi.org/10.1007/s00134-006-0163-0
  23. Mirsattari SM, Sharpe MD, Young GB. Treatment of refractory status epilepticus with inhalational anesthetic agents isoflurane and desflurane. Arch Neurol. 2004;61:1254-1259. https://doi.org/10.1001/archneur.61.8.1254
  24. Grebenchikov OA, Skripkin YV, Gerasimenko ON, Kadantseva KK, Bachinskiy AL, Berikashvili LB, Likhvantsev VV. Non-anaesthetic effects of modern halogen-containing anaesthetics. Circulation Pathology and Cardiac Surgery. 2020;24(2):26-45. (In Russ.). https://doi.org/10.21688/1681-3472-2020-2-26-45
  25. Minguet G, Joris J, Lamy M. Preconditioning and protection against ischaemia-reperfusion in non-cardiac organs: a place for volatile anaesthetics? Eur J Anaesthesiol. 2007;24(9):733-745.  https://doi.org/10.1017/S0265021507000531
  26. Cason BA, Gamperl AK, Slocum RE, Hickey RF. Anesthetic-induced preconditioning: previous administration of isoflurane decreases myocardial infarct size in rabbits. Anesthesiology. 1997;87(5):1182-1190. https://doi.org/10.1097/00000542-199711000-00023
  27. Cope DK, Impastato WK, Cohen MV, Downey JM. Volatile anesthetics protect the ischemic rabbit myocardium from infarction. Anesthesiology. 1997;86(3):699-709.  https://doi.org/10.1097/00000542-199703000-00023
  28. Kersten JR, Schmeling TJ, Pagel PS. et al. Isoflurane mimics ischemic preconditioning via activation of K(ATP) channels: reduction of myocardial infarct size with an acute memory phase. Anesthesiology. 1997;87(2):361-370.  https://doi.org/10.1097/00000542-199708000-00024
  29. Murry CE, Jennings RB, Reimer KA. Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. Circulation. 1986;74(5):1124-1136. https://doi.org/10.1161/01.cir.74.5.1124
  30. Juhaszova M, Zorov DB, Yaniv Y. et al. Role of glycogen synthase kinase-3beta in cardioprotection. Circ Res. 2009;104(11):1240-1252. https://doi.org/10.1161/CIRCRESAHA.109.197996
  31. Likhvantsev VV, Grebenchikov OA, Borisov KYU, Shaibakova VL, Shapashnikov AA, Cherpakov RA, Shmeleva EK. Mechanisms of pharmacological preconditioning of the brain and comparative effectiveness of drugs-glycogen synthetase 3-beta inhibitors of direct and indirect action (experimental study). General reanimatology. 2012;6(8):43-47. (In Russ.).] https://doi.org/10.15360/1813-9779-2012-6-37
  32. Grebenchikov OA, Avrushchenko MSH, Borisov KYU, Il’in YUV, Likhvantsev VV. Neuroprotective effects of sevoflurane on the total ischemia-reperfusion model. Klinicheskaya patofiziologiya. 2014;(2):57-65 (In Russ.).
  33. Likhvantsev VV, Skripkin YUV, Grebenchikov OA, Shaposhnikov BA, Mironenko AV. Mechanisms of action and main effects of halogen-containing anesthetics. Vestnik intensivnoi terapii. 2013;3:44-51. (In Russ.).
  34. Moroz VV, Borisov KYU., Grebenchikov OA., Levikov DI, Shaibakova VL, Cherpakov RA, Likhvantsev VV. Anaesthetic preconditioning of the myocardium and some biochemical markers of cardiac and coronary insufficiency after coronary artery bypass grafting. General reanimatology. 2013;9(5):29-35. (In Russ.). https://doi.org/10.15360/1813-9779-2013-5-29
  35. Juhaszova M, Zorov DB, Kim SH, et al. Glycogen synthase kinase-3beta mediates convergence of protection signaling to inhibit the mitochondrial permeability transition pore. J Clin Invest. 2004;113(11):1535-1549. https://doi.org/10.1172/JCI19906
  36. Wang H, Kumar A, Lamont RJ, Scott DA. GSK3β and the control of infectious bacterial diseases. Trends Microbiol. 2014;22(4):208-217.  https://doi.org/10.1016/j.tim.2014.01.009
  37. Beurel E, Michalek SM, Jope RS. Innate and adaptive immune responses regulated by glycogen synthase kinase-3 (GSK3). Trends Immunol. 2010;31(1):24-31.  https://doi.org/10.1016/j.it.2009.09.007
  38. Ramirez SH, Fan SH, Dykstra H, Rom S, Mercer A, Reichenbach NL, Gofman L, Persidsky Y. Inhibition of Glycogen Synthase Kinase 3b Promotes Tight Junction Stability in Brain Endothelial Cells by Half- Life Extension of Occludin and Claudin. PLOS ONE. 2013;8(2):559722. https://doi.org/10.1371/journal.pone.0055972
  39. Rom S, Fan S, Reichenbach N, Dykstra H, Ramirez SH, Persidsky Y. Glycogen synthase kinase 3β inhibition prevents monocyte migration across brain endothelial cells via Rac1-GTPase suppression and down-regulation of active integrin conformation. Am J Pathol. 2012;181(4):1414-1425. https://doi.org/10.1016/j.ajpath.2012.06.018
  40. Reutershan J, Chang D, Hayes JK, Ley K. Protective effects of isoflurane pretreatment in endotoxin-induced lung injury. Anesthesiology. 2006;104(3):511-517.  https://doi.org/10.1097/00000542-200603000-00019
  41. Lee HT, Kim M, Kim M, et al. Isoflurane protects against renal ischemia and reperfusion injury and modulates leukocyte infiltration in mice. Am J Physiol Renal Physiol. 2007;293(3):713-722.  https://doi.org/10.1152/ajprenal.00161.2007
  42. Lee HT, Emala CW, Joo JD, Kim M. Isoflurane improves survival and protects against renal and hepatic injury in murine septic peritonitis. Shock. 2007;27(4):373-379.  https://doi.org/10.1097/01.shk.0000248595.17130.24
  43. Hayes JK, Havaleshko DM, Plachinta RV, Rich GF. Isoflurane pretreatment supports hemodynamics and leukocyte rolling velocities in rat mesentery during lipopolysaccharide-induced inflammation. Anesth Analg. 2004;98(4):999-1006. https://doi.org/10.1213/01.ane.0000104584.91385.1d
  44. Mobert J, Zahler S, Becker BF, Conzen PF. Inhibition of neutrophil activation by volatile anesthetics decreases adhesion to cultured human endothelial cells. Anesthesiology. 1999;90(5):1372-1381. https://doi.org/10.1097/00000542-199905000-00022
  45. Likhvantsev VV, Grebenchikov OA, Skripkin YUV, Ulitkina ON, Bershadskiy FF, Stroiteleva EM. Inhalation sedation in the patients after cardiac surgery in intensive care units. Messenger of Anesthesiology and Resuscitation. 2018;15(5):46-53. (In Russ.). https://doi.org/10.21292/2078-5658-2018-15-5-46-53.
  46. Annecke T, Chappell D, Chen C, et al. Sevoflurane preserves the endothelial glycocalyx against ischaemia-reperfusion injury. Br J Anaesth. 2010;104(4):414-421.  https://doi.org/10.1093/bja/aeq019
  47. Chappell D, Heindl B, Jacob M, et al. Sevoflurane reduces leukocyte and platelet adhesion after ischemia-reperfusion by protecting the endothelial glycocalyx. Anesthesiology. 2011;115(3):483-491.  https://doi.org/10.1097/ALN.0b013e3182289988
  48. Chen C, Chappell D, Annecke T, et al. Sevoflurane mitigates shedding of hyaluronan from the coronary endothelium, also during ischemia/reperfusion: an ex vivo animal study. Hypoxia (Auckl). 2016;4:81-90.  https://doi.org/10.2147/HP.S98660
  49. Valentin JP, Hoffmann P, De Clerck F, Hammond TG, Hondeghem L. Review of the predictive value of the Langendorff heart model (Screenit system) in assessing the proarrhythmic potential of drugs. Journal of Pharmacological and Toxicological Methods. 2004;49:171-181.  https://doi.org/10.1016/j.vascn.2004.03.008
  50. Kawamura T, Kadosaki M, Nara N, et al. Effects of sevoflurane on cytokine balance in patients undergoing coronary artery bypass graft surgery. J Cardiothorac Vasc Anesth. 2006;20(4):503-508.  https://doi.org/10.1053/j.jvca.2006.01.011
  51. Schilling T, Kozian A, Senturk M, et al. Effects of volatile and intravenous anesthesia on the alveolar and systemic inflammatory response in thoracic surgical patients. Anesthesiology. 2011;115(1):65-74.  https://doi.org/10.1097/ALN.0b013e318214b9de
  52. De Conno E, Steurer MP, Wittlinger M, et al. Anesthetic-induced improvement of the inflammatory response to one-lung ventilation. Anesthesiology. 2009;110(6):1316-1326. https://doi.org/10.1097/ALN.0b013e3181a10731
  53. Stoppe C, Fahlenkamp AV, Rex S, et al. Feasibility and safety of xenon compared with sevoflurane anaesthesia in coronary surgical patients: a randomized controlled pilot study. Br J Anaesth. 2013;111(3):406-416.  https://doi.org/10.1093/bja/aet072
  54. Enlund M, Wiklund L, Lambert H. A new device to reduce the consumption of a halogenated anaesthetic agent. Anaesthesia. 2001;56(5):429-432.  https://doi.org/10.1046/j.1365-2044.2001.01900.x
  55. Sackey PV, Martling CR, Granath F, Radell PJ. Prolonged isoflurane sedation of intensive care unit patients with the Anesthetic Conserving Device. Crit Care Med. 2004;32(11):2241-2246. https://doi.org/10.1097/01.ccm.0000145951.76082.77
  56. Barr J, Fraser GL, Puntillo K, Ely EW, Gélinas C, Dasta JF, Davidson JE, Devlin JW, Kress JP, Joffe AM, Coursin DB, Herr DL, Tung A, Robinson BR, Fontaine DK, Ramsay MA, Riker RR, Sessler CN, Pun B, Skrobik Y, Jaeschke R. American College of Critical Care Medicine. Clinical practice guidelines for the management of pain, agitation, and delirium in adult patients in the intensive care unit. Crit Care Med. 2013;41(1):263-306.  https://doi.org/10.1097/CCM.0b013e3182783b72
  57. Misra S, Koshy T. A review of the practice of sedation with inhalational anaesthetics in the intensive care unit with the AnaConDa device. Indian J Anaesth. 2012;56(6):518-523.  https://doi.org/10.4103/0019-5049.104565
  58. Röhm KD, Wolf MW, Schöllhorn T, Schellhaass A, Boldt J, Piper SN. Short-term sevoflurane sedation using the Anaesthetic Conserving Device after cardiothoracic surgery. Intensive Care Med. 2008;34(9):1683-1689. https://doi.org/10.1007/s00134-008-1157-x
  59. Tempia A, Olivei MC, Calza E, et al. The anesthetic conserving device compared with conventional circle system used under different flow conditions for inhaled anesthesia. Anesth Analg. 2003;96(4):1056-1061. https://doi.org/10.1213/01.ane.0000050558.89090.95
  60. Saidman LJ, Eger EI, Munson ES, Babad AA, Muallem M. Minimum alveolar concentrations of methoxyflurane, halothane, ether and cyclopropane in man: correlation with theories of anesthesia. Anesthesiology. 1967;28(6):994-1002. https://doi.org/10.1097/00000542-196711000-00009
  61. Eger EI, Saidman LJ, Brandstater B. Minimum alveolar anesthetic concentration: a standard of anesthetic potency. Anesthesiology. 1965;26(6):756-763.  https://doi.org/10.1097/00000542-196511000-00010
  62. Nakajima R, Nakajima Y, Ikeda K. Minimum alveolar concentration of sevoflurane in elderly patients. Br J Anaesth. 1993;70(3):273-275.  https://doi.org/10.1093/bja/70.3.273
  63. Dwyer R, Bennett HL, Eger EI, Heilbron D. Effects of isoflurane and nitrous oxide in subanesthetic concentrations on memory and responsiveness in volunteers. Anesthesiology. 1992;77(5):888-898.  https://doi.org/10.1097/00000542-199211000-00009
  64. Лихванцев В.В., Борисов К.Ю., Габитов М.В., Гребенчиков О.А., Кичин В.В., Козлова Е.М., Левиков Д.И., Мурачев А.С., Тимошин С.С., Селиванов Д.Д., Скрипкин Ю.В., Сунгуров В.А., Федоров С.А., Шайбакова В.Л. Ингаляционная индукция и поддержание анестезии. Под редакцией проф. Лихванцева В.В. М.: МИА;, 2013.
  65. Likhvantsev VV, Kozlova EM, Fedorov SA, Mironenko AV, Selivanov DD. The Minimum Alveolar Concentration of Sevoflurane for Respiratory Depression. General Reanimatology. 2011;7(3):56. (In Russ.). https://doi.org/10.15360/1813-9779-2011-3-56
  66. Kong KL, Willatts SM, Prys-Roberts C. Isoflurane compared with midazolam for sedation in the intensive care unit. BMJ. 1989;298(6683):1277-1280. https://doi.org/10.1136/bmj.298.6683.1277
  67. Andropoulos DB. Effect of Anesthesia on the Developing Brain: Infant and Fetus. Fetal Diagn Ther. 2018;43(1):1-11. Epub 2017 Jun 7. PMID: 28586779. https://doi.org/10.1159/000475928
  68. Mesnil M, Capdevila X, Bringuier S, et al. Long-term sedation in intensive care unit: a randomized comparison between inhaled sevoflurane and intravenous propofol or midazolam. Intensive Care Med. 2011;37(6):933-941.  https://doi.org/10.1007/s00134-011-2187-3
  69. Hellström J, Öwall A, Martling CR, Sackey PV. Inhaled isoflurane sedation during therapeutic hypothermia after cardiac arrest: a case series. Crit Care Med. 2014;42(2):161-166.  https://doi.org/10.1097/CCM.0b013e3182a643d7
  70. De Hert S. Cardiac troponins and volatile anaesthetics in on-pump coronary surgery: How much longer do we need to state the obvious? Eur J Anaesthesiol. 2016;33(6):393-395.  https://doi.org/10.1097/EJA.0000000000000412
  71. Pshenisnov KV, Aleksandrovich YuS, Kozubov MYu. Inhalation sedation in children in intensive care unit. Russian Journal of Anaesthesiology and Reanimatology. 2021;(3):69-76. (In Russ.). https://doi.org/10.17116/anaesthesiology202103169
  72. Putanov MA, Kazarinov DN, Chetskaia KM, Tsarionova DV, Sokolova MM, Slastilin VYu, Kirov MYu. Effects of inhalation anesthesia with desflurane and sevoflurane on cognitive function after off-pump coronary arterybypass grafting. Russian Journal of Anaesthesiology and Reanimatology. 2018;(6):44-52. (In Russ.). https://doi.org/10.17116/anaesthesiology201806144
  73. Jerath A, Beattie SW, Chandy T, et al. Volatile-based short-term sedation in cardiac surgical patients: a prospective randomized controlled trial. Crit Care Med. 2015;43(5):1062-1069. https://doi.org/10.1097/CCM.0000000000000938
  74. Spence J, Belley-Côté E, Ma HK, et al. Efficacy and safety of inhaled anaesthetic for postoperative sedation during mechanical ventilation in adult cardiac surgery patients: a systematic review and meta-analysis. Br J Anaesth. 2017;118(5):658-669.  https://doi.org/10.1093/bja/aex087
  75. Marcos-Vidal JM, González R, Garcia C, Soria C, Galiana M, De Prada B. Sedation with sevoflurane in postoperative cardiac surgery: influence on troponin T and creatinine values. Heart Lung Vessel. 2014;6(1):33-42. 
  76. Guerrero Orriach JL, Galán Ortega M, Ramirez Aliaga M, Iglesias P, Rubio Navarro M, Cruz Mañas J. Prolonged sevoflurane administration in the off-pump coronary artery bypass graft surgery: beneficial effects. J Crit Care. 2013;28(5):879.e13-879.e8.79E18. https://doi.org/10.1016/j.jcrc.2013.06.004
  77. Januzzi JL, van Kimmenade R, Lainchbury J, et al. NT-proBNP testing for diagnosis and short-term prognosis in acute destabilized heart failure: an international pooled analysis of 1256 patients: the International Collaborative of NT-proBNP Study. Eur Heart J. 2006;27(3):330-337.  https://doi.org/10.1093/eurheartj/ehi631
  78. Kim HY, Lee JE, Kim HY, Kim J. Volatile sedation in the intensive care unit: A systematic review and meta-analysis. Medicine (Baltimore). 2017;96(49):e8976. https://doi.org/10.1097/MD.0000000000008976
  79. Jabaudon M, Boucher P, Imhoff E, et al. Sevoflurane for Sedation in Acute Respiratory Distress Syndrome. A Randomized Controlled Pilot Study. Am J Respir Crit Care Med. 2017;195(6):792-800.  https://doi.org/10.1164/rccm.201604-0686OC
  80. Bellgardt M, Bomberg H, Herzog-Niescery J, et al. Survival after long-term isoflurane sedation as opposed to intravenous sedation in critically ill surgical patients: Retrospective analysis. Eur J Anaesthesiol. 2016;33(1):6-13.  https://doi.org/10.1097/EJA.0000000000000252
  81. Hellström J, Öwall A, Bergström J, Sackey PV. Cardiac outcome after sevoflurane versus propofol sedation following coronary bypass surgery: a pilot study. Acta Anaesthesiol Scand. 2011;55(4):460-467.  https://doi.org/10.1111/j.1399-6576.2011.02405.x
  82. Rezepov NA, Ulitkina ON, Skripkin YUV, Zabelina TS, Likhvantsev VV. Inhalation sedation in those with sepsis-associated delirium. Messenger of anesthesiology and resuscitation. 2017;14(2):48-54. (In Russ.). https://doi.org/10.21292/2078-5658-2017-14-2-48-54
  83. Wang X, Liu Z, Shen L. Isoflurane preconditioning inhibits caspase-11-related noncanonical pyroptosis pathway to alleviate hepatic ischemia-reperfusion injury in mice. Nan Fang Yi Ke Da Xue Xue Bao. 2020;40(5):670-675.  https://doi.org/10.12122/j.issn.1673-4254.2020.05.09
  84. Chi OZ, Hunter C, Liu X, et al: The effects of isoflurane pretreatment on cerebral blood flow, capillary permeability, and oxygen consumption in focal cerebral ischemia in rats. Anesth Analg. 2010;110:1412-1418. https://doi.org/10.1213/ANE.0b013e3181d6c0ae
  85. Yao Z, Liu N, Zhu X, et al. Subanesthetic isoflurane abates ROS-activated MAPK/NF-κB signaling to repress ischemia-induced microglia inflammation and brain injury. Aging (Albany NY). 2020;12(24):26121-26139. https://doi.org/10.18632/aging.202349
  86. Zhang J, Yu P, Hua F, Hu Y, Xiao F, Liu Q, Huang D, Deng F, Wei G, Deng W, Ma J, Zhu W, Zhang J, Yu S. Sevoflurane postconditioning reduces myocardial ischemia reperfusion injury-induced necroptosis by up-regulation of OGT-mediated O-GlcNAcylated RIPK3. Aging (Albany NY). 2020;12(24):25452-25468. https://doi.org/10.18632/aging.104146.
  87. Raub D, Platzbecker K, Grabitz SD, Xu X, Wongtangman K, Pham SB, Murugappan KR, Hanafy KA, Nozari A, Houle TT, Kendale SM, Eikermann M. Effects of Volatile Anesthetics on Postoperative Ischemic Stroke Incidence. J Am Heart Assoc. 2021;10(5):e018952. https://doi.org/10.1161/JAHA.120.018952
  88. Matta BF, Heath KJ, Tipping K, et al: Direct cerebral vasodilatory effects of sevoflurane and isoflurane. Anesthesiology. 1999;91:677-680.  https://doi.org/10.1097/00000542-199909000-00019
  89. Kadoi Y, Kawauchi CH, Ide M, et al. Differential increases in blood flow velocity in the middle cerebral artery after tourniquet deflation during sevoflurane, isoflurane or propofol anaesthesia. Anaesth Intensive Care. 2009;37:598-603.  https://doi.org/10.1177/0310057X0903700412
  90. Villa F, Iacca C, Molinari AF, et al. Inhalation versus endovenous sedation in subarachnoid hemorrhage patients: effects on regional cerebral blood flow. Crit Care Med. 2012;40(10):2797-2804. https://doi.org/10.1097/CCM.0b013e31825b8bc6
  91. Chen S, Lotz C, Roewer N, Broscheit JA. Comparison of volatile anesthetic-induced preconditioning in cardiac and cerebral system: molecular mechanisms and clinical aspects. Eur J Med Res. 2018;23(1):10.  https://doi.org/10.1186/s40001-018-0308-y
  92. Jung S, Na S, Kim HB, Joo HJ, Kim J. Inhalation sedation for postoperative patients in the intensive care unit: initial sevoflurane concentration and comparison of opioid use with propofol sedation. Acute Crit Care. 2020;35(3):197-204.  https://doi.org/10.4266/acc.2020.00213
  93. A randomized controlled open-label study to confirm the efficacy and safety of sedation with isoflurane in invasively ventilated ICU patients using the AnaConDa adminidtration system. EudraCT Number: 2016-004551-67.  www.clinicaltrialsregister.eu
  94. Temesgen N, Chekol B, Tamirie T, Eshetie D, Simeneh N, Feleke A. Adult sedation and analgesia in a resource limited intensive care unit — A Systematic Review and evidence based guideline. Ann Med Surg (Lond). 2021;66:102356. https://doi.org/10.1016/j.amsu.2021.102356
  95. Devlin JW, Skrobik Y, Gélinas C, et al. Clinical Practice Guidelines for the Prevention and Management of Pain, Agitation/Sedation, Delirium, Immobility, and Sleep Disruption in Adult Patients in the ICU. Crit Care Med. 2018;46(9):825-873.  https://doi.org/10.1097/CCM.0000000000003299
  96. Aldecoa C, Bettelli G, Bilotta F, et al. European Society of Anaesthesiology evidence-based and consensus-based guideline on postoperative delirium [published correction appears in Eur J Anaesthesiol. 2018;35(9):718-719]. Eur J Anaesthesiol. 2017;34(4):192-214.  https://doi.org/10.1097/EJA.0000000000000594
  97. Zhu H, Cottrell JE, Kass IS. The effect of thiopental and propofol on NMDA- and AMPA-mediated glutamate excitotoxicity. Anesthesiology. 1997;87(4):944-951. PMID: 9357898. https://doi.org/10.1097/00000542-199710000-00030
  98. Tang Z, Yang F, Dong Y, Ma C, Sun S, Shan Y, Zhang Y, Liu H. Midazolam contributes to neuroprotection against hypoxia/reoxygenation-induced brain injury in neonatal rats via regulation of EAAT2. Brain Res Bull. 2020;161:136-146. Epub 2020 May 17. PMID: 32433937  https://doi.org/10.1016/j.brainresbull.2020.04.016
  99. Chiu KM, Lin TY, Lee MY, Lu CW, Wang MJ, Wang SJ. Dexmedetomidine protects neurons from kainic acid-induced excitotoxicity by activating BDNF signaling. Neurochem Int. 2019;129:104493. PMID: 31220473; https://doi.org/10.1016/j.neuint.2019.104493
  100. Liaquat Z, Xu X, Zilundu PLM, Fu R, Zhou L. The Current Role of Dexmedetomidine as Neuroprotective Agent: An Updated Review. Brain Sci. 2021;11(7):846. PMID: 34202110; PMCID: PMC8301952. https://doi.org/10.3390/brainsci11070846
  101. Bell JD. In Vogue: Ketamine for Neuroprotection in Acute Neurologic Injury. Anesth Analg. 2017;124(4):1237-1243. PMID: 28079589. https://doi.org/10.1213/ANE.0000000000001856
  102. Lu G, Rao D, Zhou M, Liangpu Xu, Zhang L, Zhang S, Wang Y. Autophagic Network Analysis of the Dual Effect of Sevoflurane on Neurons Associated with GABARAPL1 and 2. Biomed Res Int. 2020;2020:1587214. PMID: 32685442; PMCID: PMC7335402. https://doi.org/10.1155/2020/1587214
  103. Zhao YL, Xiang Q, Shi QY, Li SY, Tan L, Wang JT, Jin XG, Luo AL. GABAergic excitotoxicity injury of the immature hippocampal pyramidal neurons’ exposure to isoflurane. Anesth Analg. 2011;113(5):1152-1160. Epub 2011 Sep 14. PMID: 21918167. https://doi.org/10.1213/ANE.0b013e318230b3fd
  104. Currier DS, Bevacqua BK. Acute tachyphylaxis to propofol sedation during ethanol withdrawal. J Clin Anesth. 1997;9(5):420-423. PMID: 9257211. https://doi.org/10.1016/s0952-8180(97)00019-6
  105. Tanigami H, Yahagi N, Kumon K, Watanabe Y, Haruna M, Matsui J, Hayashi H. Long-term sedation with isoflurane in postoperative intensive care in cardiac surgery. Artif Organs. 1997;21(1):21-23. PMID: 9012901. https://doi.org/10.1111/j.1525-1594.1997.tb00693.x
  106. Walker J, Maccallum M, Fischer C, Kopcha R, Saylors R, McCall J. Sedation using dexmedetomidine in pediatric burn patients. J Burn Care Res. 2006;27(2):206-210. PMID: 16566567. https://doi.org/10.1097/01.BCR.0000200910.76019.CF
  107. Nakamura T, Karakida N, Dantsuka A, Ichii O, Elewa YHA, Kon Y, Nagasaki KI, Hattori H, Yoshiyasu T. Effects of a mixture of medetomidine, midazolam and butorphanol on anesthesia and blood biochemistry and the antagonizing action of atipamezole in hamsters. J Vet Med Sci. 2017;79(7):1230-1235. Epub 2017 Jun 11. PMID: 28603217; PMCID: PMC5559369. https://doi.org/10.1292/jvms.17-0210
  108. Filbey WA, Sanford DT, Baghdoyan HA, Koch LG, Britton SL, Lydic R. Eszopiclone and dexmedetomidine depress ventilation in obese rats with features of metabolic syndrome. Sleep. 2014;37(5):871-880. PMID: 24790265; PMCID: PMC3985114. https://doi.org/10.5665/sleep.3650
  109. Ng SY, Chin KJ, Kwek TK. Dyskalaemia associated with thiopentone barbiturate coma for refractory intracranial hypertension: a case series. Intensive Care Med. 2011;37(8):1285-1289. Epub 2011 May 13. PMID: 21567112. https://doi.org/10.1007/s00134-011-2240-2
  110. Selvanayagam J, Johnston KD, Wong RK, Schaeffer D, Everling S. Ketamine disrupts gaze patterns during face viewing in the common marmoset. J Neurophysiol. 2021;126(1):330-339. Epub 2021 Jun 16. PMID: 34133232. https://doi.org/10.1152/jn.00078.2021
  111. Mongodi S, Ottonello G, Viggiano R, Borrelli P, Orcesi S, Pichiecchio A, Balottin U, Mojoli F, Iotti GA. Ten-year experience with standardized non-operating room anesthesia with Sevoflurane for MRI in children affected by neuropsychiatric disorders. BMC Anesthesiol. 2019;19(1):235. PMID: 31852450; PMCID: PMC6921558. https://doi.org/10.1186/s12871-019-0897-1
  112. Oshima T, Karasawa F, Okazaki Y, Wada H, Satoh T. Effects of sevoflurane on cerebral blood flow and cerebral metabolic rate of oxygen in human beings: a comparison with isoflurane. Eur J Anaesthesiol. 2003;20(7):543-547. PMID: 12884987. https://doi.org/10.1017/s0265021503000863
  113. George AA, Hargrove VM, Molina DK. Postmortem Propofol Levels: A Case of Residual Detection Long After Administration. Am J Forensic Med Pathol. 2016;37(1):4-6. PMID: 26513757. https://doi.org/10.1097/PAF.0000000000000209
  114. Bolon M, Boulieu R, Flamens C, Paulus S, Bastien O. Sédation par le midazolam en réanimation: aspects pharmacologiques et pharmacocinétiques [Sedation induced by midazolam in intensive care: pharmacologic and pharmacokinetic aspects]. Ann Fr Anesth Reanim. 2002;21(6):478-92. French. PMID: 12134593. https://doi.org/10.1016/s0750-7658(02)00662-7
  115. Ashraf MW, Uusalo P, Scheinin M, Saari TI. Population Modelling of Dexmedetomidine Pharmacokinetics and Haemodynamic Effects After Intravenous and Subcutaneous Administration. Clin Pharmacokinet. 2020;59(11):1467-1482. PMID: 32462542; PMCID: PMC7658092. https://doi.org/10.1007/s40262-020-00900-3
  116. Roth LJ, Barlow CF. Drugs in the brain. Science. 1961;134(3471):22-31. PMID: 13743847. https://doi.org/10.1126/science.134.3471.22
  117. Hill GE, Anderson JL, Whitten CW. Ketamine inhibits agonist-induced cAMP accumulation increase in human airway smooth muscle cells. Can J Anaesth. 1999;46(12):1172-1177. PMID: 10608213. https://doi.org/10.1007/BF03015528
  118. Az-ma T, Fujii K, Yuge O. Inhibitory effect of sevoflurane on nitric oxide release from cultured endothelial cells. Eur J Pharmacol. 1995;289(1):33-39. PMID: 7781710. https://doi.org/10.1016/0922-4106(95)90165-5
  119. Du GZ, Gao H, Liu J, Wu GS, He X, Zeng XG, Hu XY, Li XH. Isoflurane pre-treatment before cardiopulmonary bypass alleviates neutrophil accumulation in dog lungs. Cardiovasc J Afr. 2011;22(3):128-133. Epub 2010 Nov 9. PMID: 21107494; PMCID: PMC3721866. https://doi.org/10.5830/cvja-2010-055
  120. Uhrig L, Janssen D, Dehaene S, Jarraya B. Cerebral responses to local and global auditory novelty under general anesthesia. Neuroimage. 2016;141:326-340. Epub 2016 Aug 5. PMID: 27502046; PMCID: PMC5635967. https://doi.org/10.1016/j.neuroimage.2016.08.004
  121. Ichimiya Y, Kaku N, Sakai Y, Yamashita F, Matsuoka W, Muraoka M, Akamine S, Mizuguchi S, Torio M, Motomura Y, Hirata Y, Ishizaki Y, Sanefuji M, Torisu H, Takada H, Maehara Y, Ohga S. Transient dysautonomia in an acute phase of encephalopathy with biphasic seizures and late reduced diffusion. Brain Dev. 2017;39(7):621-624. Epub 2017 Apr 13. PMID: 28413125. https://doi.org/10.1016/j.braindev.2017.03.023
  122. Rozet I. Anesthesia for functional neurosurgery: the role of dexmedetomidine. Curr Opin Anaesthesiol. 2008;21(5):537-543. PMID: 18784476. https://doi.org/10.1097/ACO.0b013e32830edafd
  123. Flaishon R, Windsor A, Sigl J, Sebel PS. Recovery of consciousness after thiopental or propofol. Bispectral index and isolated forearm technique. Anesthesiology. 1997;86(3):613-619.  https://doi.org/10.1097/00000542-199703000-00013. PMID: 9066327.
  124. Xing Y, Li K, Jiao Y, Li Z. Propofol Causes Consciousness Loss by Affecting GABA-A Receptor in the Nucleus Basalis of Rats. Behav Neurol. 2020;2020:9370891. PMID: 32148565; PMCID: PMC7053451. https://doi.org/10.1155/2020/9370891
  125. Palanca BJA, Avidan MS, Mashour GA. Human neural correlates of sevoflurane-induced unconsciousness. Br J Anaesth. 2017;119(4):573-582. PMID: 29121298; PMCID: PMC6172973. https://doi.org/10.1093/bja/aex244
  126. Baer AG, Bourdon AK, Price JM, Campagna SR, Jacobson DA, Baghdoyan HA, Lydic R. Isoflurane anesthesia disrupts the cortical metabolome. J Neurophysiol. 2020;124(6):2012-2021. Epub 2020 Oct 28. PMID: 33112692; PMCID: PMC7814899. https://doi.org/10.1152/jn.00375.2020
  127. Buck RK, Meyer LRC, Stegmann GF, Kästner SBR, Kummrow M, Gerlach C, Fosgate GT, Zeiler GE. Propofol-medetomidine-ketamine total intravenous anaesthesia in thiafentanil-medetomidine-immobilized impala (Aepyceros melampus). Vet Anaesth Analg. 2017;44(1):138-143. Epub 2017 Feb 23. PMID: 27302030. https://doi.org/10.1111/vaa.12402
  128. Zeira M, Tverskoy M. Midazolam — opiates drug interaction in induction of anesthesia: additive or synergistic? Harefuah. 1992;123(10):414-416. Hebrew. PMID: 1464393.
  129. Cherksey BD, Altszuler N. On the mechanism of potentiation by morphine of thiopental sleeping time. Pharmacology. 1974;12(6):362-371. PMID: 4456429. https://doi.org/10.1159/000136560
  130. Bell RF, Eccleston C, Kalso EA. Ketamine as an adjuvant to opioids for cancer pain. Cochrane Database Syst Rev. 2017;6(6):CD003351. PMID: 28657160; PMCID: PMC6481583. https://doi.org/10.1002/14651858.CD003351.pub3
  131. Pokkinen SM, Yli-Hankala A, Kalliomäki ML. The effects of propofol vs. sevoflurane on post-operative pain and need of opioid. Acta Anaesthesiol Scand. 2014;58(8):980-985. Epub 2014 Jul 10. PMID: 25039403. https://doi.org/10.1111/aas.12366
  132. Horn CC, Meyers K, Pak D, Nagy A, Apfel CC, Williams BA. Post-anesthesia vomiting: impact of isoflurane and morphine on ferrets and musk shrews. Physiol Behav. 2012;106(4):562-568. Epub 2012 Apr 4. PMID: 22504494; PMCID: PMC3348962. https://doi.org/10.1016/j.physbeh.2012.03.031
  133. Jakob SM, Ruokonen E, Grounds RM, Sarapohja T, Garratt C, Pocock SJ, Bratty JR, Takala J; Dexmedetomidine for Long-Term Sedation Investigators. Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials. JAMA. 2012;307(11):1151-1160. PMID: 22436955. https://doi.org/10.1001/jama.2012.304
  134. Abdennour L, Puybasset L. La sédation-analgésie du patient cérébrolésé [Sedation and analgesia for the brain-injured patient]. Ann Fr Anesth Reanim. 2008;27(7-8):596-603. French. Epub 2008 Jul 10. PMID: 18619762. https://doi.org/10.1016/j.annfar.2008.04.012
  135. Manasco AT, Stephens RJ, Yaeger LH, Roberts BW, Fuller BM. Ketamine sedation in mechanically ventilated patients: A systematic review and meta-analysis. J Crit Care. 2020;56:80-88. Epub 2019 Dec 9. PMID: 31865256. https://doi.org/10.1016/j.jcrc.2019.12.004
  136. Jerath A, Panckhurst J, Parotto M, Lightfoot N, Wasowicz M, Ferguson ND, Steel A, Beattie WS. Safety and Efficacy of Volatile Anesthetic Agents Compared With Standard Intravenous Midazolam/Propofol Sedation in Ventilated Critical Care Patients: A Meta-analysis and Systematic Review of Prospective Trials. Anesth Analg. 2017;124(4):1190-1199. PMID: 27828800. https://doi.org/10.1213/ANE.0000000000001634
  137. Scherer C, Kupka D, Stocker TJ, Joskowiak D, Scheuplein H, Schönegger CM, Born F, Stremmel C, Lüsebrink E, Stark K, Orban M, Petzold T, Peterss S, Hausleiter J, Hagl C, Massberg S, Orban M. Isoflurane Sedation in Patients Undergoing Venoarterial Extracorporeal Membrane Oxygenation Treatment for Cardiogenic Shock-An Observational Propensity-Matched Study. Crit Care Explor. 2020;2(3):e0086. PMID: 32259109; PMCID: PMC7098543. https://doi.org/10.1097/CCE.0000000000000086
  138. Subramaniam B, Shankar P, Shaefi S, Mueller A, O’Gara B, Banner-Goodspeed V, Gallagher J, Gasangwa D, Patxot M, Packiasabapathy S, Mathur P, Eikermann M, Talmor D, Marcantonio ER. Effect of Intravenous Acetaminophen vs Placebo Combined With Propofol or Dexmedetomidine on Postoperative Delirium Among Older Patients Following Cardiac Surgery: The DEXACET Randomized Clinical Trial. JAMA. 2019;321(7):686-696. Erratum in: JAMA. 2019 Jul 16;322(3):276. PMID: 30778597; PMCID: PMC6439609. https://doi.org/10.1001/jama.2019.0234
  139. Prommer E. Midazolam: an essential palliative care drug. Palliat Care Soc Pract. 2020;14:2632352419895527. PMID: 32215374; PMCID: PMC7065504. https://doi.org/10.1177/2632352419895527
  140. Sneyd JR. Thiopental to desflurane — an anaesthetic journey. Where are we going next? Br J Anaesth. 2017;119(suppl 1):44-52. PMID: 29161390. https://doi.org/10.1093/bja/aex328
  141. Avidan MS, Maybrier HR, Abdallah AB, Jacobsohn E, Vlisides PE, Pryor KO, Veselis RA, Grocott HP, Emmert DA, Rogers EM, Downey RJ, Yulico H, Noh GJ, Lee YH, Waszynski CM, Arya VK, Pagel PS, Hudetz JA, Muench MR, Fritz BA, Waberski W, Inouye SK, Mashour GA; PODCAST Research Group. Intraoperative ketamine for prevention of postoperative delirium or pain after major surgery in older adults: an international, multicentre, double-blind, randomised clinical trial. Lancet. 2017;390(10091):267-275. Epub 2017 May 30. Erratum in: Lancet. 2017;390(10091):230. PMID: 28576285; PMCID: PMC5644286. https://doi.org/10.1016/S0140-6736(17)31467-8
  142. Nair A. Farmacogenômica do sevoflurano: papel no delirium do despertar [Pharmacogenomics of sevoflurane: role in emergence delirium]. Braz J Anesthesiol. 2019;69(4):423. Portuguese. Epub 2019 Jul 11. PMID: 31303310. https://doi.org/10.1016/j.bjan.2019.03.003
  143. Xie Z, Dong Y, Maeda U, Moir R, Inouye SK, Culley DJ, Crosby G, Tanzi RE. Isoflurane-induced apoptosis: a potential pathogenic link between delirium and dementia. J Gerontol A Biol Sci Med Sci. 2006;61(12):1300-1306. PMID: 17234824. https://doi.org/10.1093/gerona/61.12.1300
  144. Li Volti G, Avola R, Tibullo D. Editorial — Propofol as an intraoperative strategy for organ protection. Eur Rev Med Pharmacol Sci. 2017;21(17):3980-3981. PMID: 28975962.
  145. Li J, Tan H, Zhou X, Zhang C, Jin H, Tian Y, Zhao X, Li X, Sun X, Duan M, Zhang D. The Protection of Midazolam Against Immune Mediated Liver Injury Induced by Lipopolysaccharide and PMID: 30670973; PMCID: PMC6331471.Galactosamine in Mice. Front Pharmacol. 2019;9:1528. https://doi.org/10.3389/fphar.2018.01528
  146. Bao N, Tang B. Organ-Protective Effects and the Underlying Mechanism of Dexmedetomidine. Mediators Inflamm. 2020;2020:6136105. PMID: 32454792; PMCID: PMC7232715. https://doi.org/10.1155/2020/6136105
  147. Dogan Z, Yuzbasioglu MF, Kurutas EB, Yildiz H, Coskuner I, Senoglu N, Oksuz H, Bülbüloglu E. Thiopental improves renal ischemia-reperfusion injury. Ren Fail. 2010;32(3):391-395. PMID: 20370458. https://doi.org/10.3109/08860221003611752
  148. Yin J, Fu B, Zhang Y, Yu T. Effect of ketamine on voltage-gated potassium channels in rat primary sensory cortex pyramidal neurons. Neuroreport. 2020;31(8):583-589. PMID: 32301815. https://doi.org/10.1097/WNR.0000000000001439
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