Modern concepts of pain mechanisms

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The idea of this article is to focus the pain mechanisms. There are nociception, peripheral sensitization, central sensitization, ectopic neuronal activity, peripheral disinhibition, central disinhibition, and efferent-afferent conduit that are known well. Importantly, any of them can contribute in pain appearance wherein in any combination. To our opinion because the detection of pain mechanism precisely gives the opportunity of treatment of pain based on pathogenesis these representations could be useful for creation of new approaches to management of chronic pain.

Keywords:

pain mechanisms

nociception

peripheral sensitization

central sensitization

ectopic neuronal activity

disinhibition

Authors:

Karelov A.E.

North-Western State Medical University named after I.I. Mechnikov

Scopus AuthorID: 6508037675
ORCID: 0000-0003-4401-1599

Received:

23.06.2020

Accepted:

21.07.2020

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