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Sokologorskiy S.V.
I.M. Sechenov First Moscow State Medical University, 119991, Moscow, Russia ,
Glycocalyx — birth of a new clinical paradigm
Journal: Russian Journal of Anesthesiology and Reanimatology. 2018;(4): 22‑29
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To cite this article:
Sokologorskiy SV. Glycocalyx — birth of a new clinical paradigm. Russian Journal of Anesthesiology and Reanimatology.
2018;(4):22‑29. (In Russ.)
https://doi.org/10.17116/anaesthesiology201804122
Endothelial dysfunction underlies many diseases and pathological processes. It was believed for a long time that these disorders are a consequence of direct damage and malfunction of the endothelial cell itself. A huge number of studies showing that the true cause of those dysfunctions is the destruction of glycocalyx — a thin molecular structure of the proteoglycans, glycoproteins and glycosaminglycans located on the endothelial surface, has appeared recently. The structure, function, and destruction of the glycocalyx are reviewed.
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Sokologorskiy S.V.
I.M. Sechenov First Moscow State Medical University, 119991, Moscow, Russia ,
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