Association study of the Val158Met polymorphism of the catechol-O-methyltransferase gene and alcoholism and heroin dependence: the role of a family history

Kibitov A.O.

Laboratoriia molekuliarnoĭ genetiki Natsional'nogo nauchnogo tsentra narkologii, Moskva

Voskoboeva E.Iu.

Moskovskiĭ oblastnoĭ NII akusherstva i ginekologii

Brodianskiĭ V.M.

Laboratoriia molekuliarnoĭ genetiki Natsional'nogo nauchnogo tsentra narkologii, Moskva

Chuprova N.A.

Laboratoriia molekuliarnoĭ genetiki Natsional'nogo nauchnogo tsentra narkologii, Moskva

Smirnova E.V.

FGBU "Ivanovskiĭ nauchno-issledovatel'skiĭ institut materinstva i detstva im. V.N. Gorodkova" Minzdrava Rossii, Ivanovo, Rossiia

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2010;110(4): 84–88

Association study of the Val158Met polymorphism of the catechol-O-methyltransferase gene and alcoholism and heroin dependence: the role of a family history

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Kibitov A.O., Voskoboeva E.Iu., Brodianskiĭ V.M., Chuprova N.A., Smirnova E.V.

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Kibitov AO, Voskoboeva EIu, Brodianskiĭ VM, Chuprova NA, Smirnova EV. Association study of the Val158Met polymorphism of the catechol-O-methyltransferase gene and alcoholism and heroin dependence: the role of a family history. S.S. Korsakov Journal of Neurology and Psychiatry. 2010;110(4):84‑88. (In Russ.).

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The aim of this study was to investigate the association the Val158Met polymorphism of the catechol-O-methyltransferase (COMT) gene and predisposition to alcoholism and heroin dependence. The authors genotyped DNA samples from 964 Russian males (395 alcoholics, 243 heroin addicts and 326 healthy controls). The association between the Val158Met COMT polymorphism and alcoholism was found in males with high density of family history (two or more blood relatives with alcoholism within the family). In this group, the frequency of a L (Met) allele was significantly higher in comparison with controls (p=0,001), patients without family history (p=0,034) and patients with the mild density of family history (p=0,0005). The frequency of the HH (ValVal) genotype was reduced as well compared to the controls (p=0,003). In the group of heroin addicts with the mild density of family history, there was a trend to lower frequency of the HH genotype (p=0,058) compared to patients without family history. The results suggest that the functional Val158Met COMT polymorphism is one of the significant markers of genetic predisposition to addiction diseases.

Keywords:

gene polymorphism

catechol-O-methyltransferase

alcoholism

heroin dependence

family history

Authors:

Kibitov A.O.

Laboratoriia molekuliarnoĭ genetiki Natsional'nogo nauchnogo tsentra narkologii, Moskva

Voskoboeva E.Iu.

Moskovskiĭ oblastnoĭ NII akusherstva i ginekologii

Brodianskiĭ V.M.

Laboratoriia molekuliarnoĭ genetiki Natsional'nogo nauchnogo tsentra narkologii, Moskva

Chuprova N.A.

Laboratoriia molekuliarnoĭ genetiki Natsional'nogo nauchnogo tsentra narkologii, Moskva

Smirnova E.V.

FGBU "Ivanovskiĭ nauchno-issledovatel'skiĭ institut materinstva i detstva im. V.N. Gorodkova" Minzdrava Rossii, Ivanovo, Rossiia

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