Immunogenetic criteria for prediction of severe leprotic polyneuritis course

Close metadata

OBJECTIVE

To identify genetic markers related to the development of leprotic polyneuropathy.

MATERIAL AND METHODS

A number of patients equal 42 with multibacterial leprosy of the Russian population sample of residents of the Astrakhan endemic leprosy region were examined, including 21 patients with severe polyneuritis and 21 with sensitive disorders of the peripheral nervous system. HLA-genotyping on the alleles of the DRB1, DQA1 and DQB1 loci was carried out by PCR using HLA-DNA-Tech sets. The frequency distribution of haplotypes was determined based on the ratio of the number of individuals «carrying» this allele or haplotype to the total number of individuals in the sample.

RESULTS

More than two-fold (2.4) increase in frequency of HLA-DRB1*15-DQA1*0102-DQB1*0602/08 haplotype occurrence in patients suffering from leprosy with a severe leprotic polyneuritis (II degree of disability according to WHO) was established, which was 0.571 compared to patients with sensitive disorders of the peripheral nervous system (0.238) (p<0.05).

CONCLUSION

The use of the immunogenetic marker in the form of the presence in the patient’s genotype of the HLA-DRB1*15-DQA1*0102-DQB1*0602/08 haplotype makes it possible to predict the development of the severe course of leprotic polyneuritis both at the beginning of the disease and in its long-term period.

Keywords:

Authors:

L.V. Saroyants

Astrakhan State Medical University;
Astrakhan State University named after V.N. Tatishchev

ORCID: 0000-0002-4426-3860

V.Z. Naumov

Astrakhan State Medical University

A.V. Naumov

Astrakhan State Medical University

ORCID: 0000-0001-7874-7057

Received:

06.07.2023

Accepted:

16.11.2023

List of references:

World Health Organization. Monitoring the global leprosy situation, 2023. Accessed 27 January 2023. https://www.who.int/news-room/fact-sheets/detail/leprosy
World Health Organization. Global leprosy (Hansen’s Disease) strategy 2021–2030. Accessed 15 April 2021. https://apps.who.int/iris/rest/bitstreams/1353867/retrieve
van Brakel WH, Sihombing B, Djarir H, Beise K, Kusumawardhani L, Yulihane R, Kurniasari I, Kasim M, Kesumaningsih KI, Wilder-Smith A. Disability in people affected by leprosy: the role of impairment, activity, social participation, stigma and discrimination. Glob Health Action. 2012;5:1-11. https://doi.org/10.3402/gha.v5i0.18394
Wilder-Smith EP, Van Brake WH. Nerve damage in leprosy and its management. Nat Clin Pract Neurol. 2008;4:656-663. https://doi.org/10.1038/ncpneuro0941
Baranov YuN, Evstratova VA, Podoplelov II. Finger dermatoglyphics in leprosy patients with severe neurological disorders Aktual’nye voprosy leprologii. Astrakhan. 1984;90-94. (In Russ.).
van Brakel JW, Brandsma JW. WHO disability grading: operational definitions. Lepr rev. 2003;74:366-373.
Castanheira ATL, Bandeira SS, Chichester AVA, dos Reis ALM, Nascimento CVS, Palheta CSA, Loureiro WR, Carneiro FRO, Pires CAA. Sensitive damage in leprosy: A longitudinal and retrospective study. Int Arch Med. 2020;13:1-9. https://doi.org/10.3823/2618
Pevnitskii LA. Statistical evaluation of associations of HLA antigens with diseases. Vestnik AMN SSSR. 1998;7:48-51. (In Russ.).
World Health Organization. Global Leprosy Strategy 2016-2020: Accelerating towards a Leprosy-Free World. Monitoring and Evaluation Guide. 2016. Accessed February, 10, 2018. https://apps.who.int/iris/handle/10665/208824
Santos VS, Santana JC, Castro FD, Oliveira LS, Santana JC, Feitosa VL, Gurgel RQ, Cuevas LE. Pain and quality of life in leprosy patients in an endemic area of Northeast Brazil: a cross-sectional study. Infect Dis Poverty. 2016;7:5:18. https://doi.org/10.1186/s40249-016-0113-1
Naaz F, Mohanty PS, Bansal AK, Kumar D, Gupta UD. Challenges beyond elimination in leprosy. Int J Mycobacteriol. 2017;6:222-228.
Reyila VP, Betsy A, Riyaz N, Sasidharanpillai S, Sherjeena PVB, Majitha MP, Joseph DM. Clinico-epidemiological Study of Disability Due to Leprosy at the Time of Diagnosis among Patients Attending a Tertiary Care Institution. Indian J Dermatol. 2019;64(2):106-111.
Sarkar J, Das Gupta U, Mondal PK, Ghosh PK. Clinical and social determinants of disability among new patients with leprosy: a clinical hospital study in rural West Bengal, India. J Dent Med Sci. 2016;15:1-7.
Shumet T, Demissi M, Bekele Y. Prevalence of disability and related factors among registered leprosy patients throughout Africa Tuberculosis and Leprosy Rehabilitation and Education Center (ALERT), Addis Ababa, Ethiopia. Ethiopian J Health Sci. 2015;25:313-320. https://doi.org/10.4314/ejhs.v25i4.4
Rathod SP, Jagati A, Chowdhary P. Disabilities in leprosy: an open retrospective analyses of institutional records. An Bras Dermatol. 2020;95(1):52-56. https://doi.org/10.1016/j.abd.2019.07.001
Chen X, Liu HB, Shui TJ, Zha S. Risk factors for physical disability in patients with leprosy disease in Yunnan, China: Evidence from a retrospective observational study. PLoS Negl Trop Dis. 2021;15(11):e0009923. https://doi.org/10.1371/journal.pntd.0009923
Kumar A, Girdhar A, Girdhar BK. Risk of disability in the treatment of polybacillary leprosy before and after multidrug use: the Agra MB cohort study. Open BMJ. 2012;2:e000361. https://doi.org/10.1136/bmjopen-2011-000361
Moet FJ, Pahan D, Schuring RP, Oskam L, Richardus JH. Physical distance, genetic relationship, age, and leprosy classification are independent risk factors for leprosy in contacts of patients with leprosy. The Journal of infectious diseases. 2006;193(3):346-353. https://doi.org/10.1086/499278
Sarkar J, Dasgupta A, Dutt D. Disability among new leprosy patients, an issue of concern: An institution based study in an endemic district for leprosy in the state of West Bengal, India. Indian J Dermatol Venereol Leprol. 2012; 78:328-334. https://doi.org/10.4103/0378-6323.95449
Oliynyk RT. Age-related late-onset disease heritability patterns and implications for genome-wide association studies. Peer J. 2019;7:e7168. https://doi.org/10.7717/peerj.7168
Price AL, Spencer CC, Donnelly P. Progress and promise in understanding the genetic basis of common diseases. Proc Biol Sci. 2015;282(1821):20151684. https://doi.org/10.1098/rspb.2015.1684
das Santos DF, Antunes DE, Dornelas BC, da Cunha BA, Oliveira TJ, Pereira RC, Goulart LR, Goulart IMB. Peripheral nerve biopsy: A tool still needed in the early diagnosis of neural leprosy? Trans R Soc Trop Med Hyg. 2020;114 (11):792-797. https://doi.org/10.1093/trstmh/traa053
Cajueiro MA, Cavalcanti BM, Cavalcanti CM, Brito MFM, Bonfim C, Cunha Correia CD. Small-fibre neuropathy in leprosy the role of in vivo confocal microscopy: A cross-sectional study. Indian J Dermatol Venereol Leprol. 2022;1:1-6.
Hamrah P, Dana MR. Corneal antigen-presenting cells. Chem Immunol Allergy. 2007;92:58-60. https://doi.org/10.1159/000099254