The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-4329
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2026
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Chizhova K.A.

Almazov National Medical Research Centre

Mavlyutova R.R.

Almazov National Medical Research Centre

Vinnikov V.M.

Almazov National Medical Research Centre

Belov I.Yu.

Almazov National Medical Research Centre;
Petrov National Medical Research Centre of Oncology

Gulyaev D.A.

Almazov National Medical Research Centre;
Petrov National Medical Research Centre of Oncology

Giant cavernous malformation of the genu of the corpus callosum

Authors:

Chizhova K.A., Mavlyutova R.R., Vinnikov V.M., Belov I.Yu., Gulyaev D.A.

More about the authors

Journal: Burdenko's Journal of Neurosurgery. 2026;90(1): 92‑99

DOI: 10.17116/neiro20269001192

Read: 506 times

Buy PDF (RU) for 300₽
Download PDF (EN)
Contact the author
Table of contents

GIANT CAVERNOUS MALFORMATION OF THE GENU OF THE CORPUS CALLOSUM
GIANT CAVERNOUS MALFORMATION OF THE GENU OF THE CORPUS CALLOSUM

To cite this article:

Chizhova KA, Mavlyutova RR, Vinnikov VM, Belov IYu, Gulyaev DA. Giant cavernous malformation of the genu of the corpus callosum. Burdenko's Journal of Neurosurgery. 2026;90(1):92‑99. (In Russ., In Engl.)
https://doi.org/10.17116/neiro20269001192

Подписка 2025 Журнал «Вопросы нейрохирургии» имени Н.Н. Бурденко (Burdenko's Journal of Neurosurgery)
МСФ на ЯМ
Использование инфографики авторами научных работ
Close metadata
Recommended articles:
Epileptic seizures in patients with Alzheimer’s disease. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(11):36-43
Abstract:

Cavernous malformations of the corpus callosum are rare accounting for less than 1% of all subtentorial cavernous malformations. Clinical manifestations are usually caused by hemorrhage into adjacent parenchyma. Epileptic seizures are the most common. Multiple hemorrhages with progressive neurological impairment require surgical intervention.

OBJECTIVE

To present giant cavernoma of the genu of the corpus callosum extending to the fornix, basal frontal lobes and bottom of the third ventricle, as well as review of available literature.

RESULTS

A patient with giant cavernous malformation of the genu of the corpus callosum extending to the fornix, basal frontal lobes and bottom of the third ventricle underwent total resection of malformation. Symptoms included headaches, epileptic seizures, and hydrocephalus. Korsakoff syndrome developed after surgery and partially regressed at discharge. After 3 months, hydrocephalus completely regressed. Elements of Korsakoff syndrome persisted with improvements under rehabilitation sessions with neuropsychologist.

CONCLUSION

Despite difficult anatomical location and giant size, total resection of cavernous malformation provided satisfactory outcome with minimal neurological complications.

Keywords:

cavernous malformation
genu of the corpus callosum
epileptic seizures
biventricular hydrocephalus
Korsakoff syndrome

Authors:

Chizhova K.A.

Almazov National Medical Research Centre

Mavlyutova R.R.

Almazov National Medical Research Centre

Vinnikov V.M.

Almazov National Medical Research Centre

Belov I.Yu.

Almazov National Medical Research Centre;
Petrov National Medical Research Centre of Oncology

Gulyaev D.A.

Almazov National Medical Research Centre;
Petrov National Medical Research Centre of Oncology

Received:

16.11.2024

Accepted:

03.09.2025

Close metadata

References:

  1. Tasiou A, Brotis AG, Kalogeras A, Tzerefos C, Alleyne CH Jr, Andreou A, Demetriades AK, Foroglou N, Friedlander RM, Karlsson B, Kitchen N, Meling TR, Mitsos A, Panagiotopoulos V, Papasilekas T, Pavesi G, Rasulic L, Santos AN, Spetzler RF, Sure U, Tjoumakaris S, Tolias CM, Vajkoczy P, Fountas KN. Cavernous malformations of the central nervous system: An international consensus statement. Brain and Spine. 2023;3:102707. https://doi.org/10.1016/j.bas.2023.102707
  2. Labauge P, Denier C, Bergametti F, Tournier-Lasserve E. Genetics of cavernous angiomas. The Lancet Neurology. 2007;6(3):237-244.  https://doi.org/10.1016/S1474-4422(07)70053-4
  3. Washington CW, McCoy KE, Zipfel GJ. Update on the natural history of cavernous malformations and factors predicting aggressive clinical presentation. Neurosurgical Focus. 2010;29(3):E7.  https://doi.org/10.3171/2010.5.FOCUS10149
  4. Cornelius JF, Kürten K, Fischer I, Hänggi D, Steiger HJ. Quality of life after surgery for cerebral cavernoma: brainstem versus nonbrainstem location. World Neurosurgery. 2016;95:315-321.  https://doi.org/10.1016/j.wneu.2016.08.014
  5. Del Curling O Jr, Kelly DL Jr, Elster AD, Craven TE. An analysis of the natural history of cavernous angiomas. Journal of Neurosurgery. 1991;75(5):702-708.  https://doi.org/10.3171/jns.1991.75.5.0702
  6. Rosenow F, Alonso-Vanegas MA, Baumgartner C, Blümcke I, Carreño M, Gizewski ER, Hamer HM, Knake S, Kahane P, Lüders HO, Mathern GW, Menzler K, Miller J, Otsuki T, Ozkara C, Pitkänen A, Roper SN, Sakamoto AC, Sure U, Walker MC, Steinhoff BJ. Cavernoma-related epilepsy: review and recommendations for management — report of the Surgical Task Force of the ILAE Commission on Therapeutic Strategies. Epilepsia. 2013;54(12):2025-2035. https://doi.org/10.1111/epi.12402
  7. Reyns N, Assaker R, Louis E, Lejeune JP. Intraventricular cavernomas: three cases and review of the literature. Neurosurgery. 1999;44(3),648-655.  https://doi.org/10.1097/00006123-199903000-00119
  8. Harada S, Niimi M, Murakami K, Nakamura T. Cavernous angioma of the corpus callosum mimicking an astrocytic tumor — case report. Neurologia medico-chirurgica. 2001;41(7):349-351.  https://doi.org/10.2176/nmc.41.349
  9. Zacharia TT, Shah JR, Patkar DP, Varma R. Co-existing spinal cord and brain cavernous angiomas. Journal of the Association of Physicians of India. 2001;08(49):835-837. 
  10. Alves de Sousa A. Cavernomes profonds (corps calleux, intraventriculaires, ganglions de la base, insulaires) et du tronc cérébral. Expérience d’une série brésilienne [Deep-seated (corpus callosum, intraventricular, basal ganglia and insula) and brain stem cavernous angiomas. Experience in Brazil]. Neuro-Chirurgie. 2007;53(2-3 Pt 2):182-191. (In French). https://doi.org/10.1016/j.neuchi.2007.03.008
  11. Prada F, Saladino A, Giombini S. Trigonal cavernous angioma presenting with selective ventricular exclusion. Journal of Neurosurgical Sciences. 2010;54(4):153-157. 
  12. Ozer E, Yücesoy K, Kalemci O. Demonstrated rapid growth of a corpus callosum cavernous angioma within a short period of time. Journal of Neurosurgical Sciences. 2005;49(4):155-158; discussion 158. 
  13. Chang EF, Gabriel RA, Potts MB, Berger MS, Lawton MT. Supratentorial cavernous malformations in eloquent and deep locations: surgical approaches and outcomes. Clinical article. Journal of Neurosurgery. 2011;114(3):814-827.  https://doi.org/10.3171/2010.5.JNS091159
  14. Pavesi G, Causin F, Feletti A. Cavernous angioma of the corpus callosum presenting with acute psychosis. Behavioural Neurology. 2014;2014:243286. https://doi.org/10.1155/2014/243286
  15. Saleem MA, Zahra NE, Hemani F, Jan Ali A, Gilani A. Cerebral Cavernous Angioma Associated with Klippel Trenaunay Syndrome Treated with Gamma Knife Radiosurgery: Case Report and Literature Review. Cureus. 2019;11(3):e4318. https://doi.org/10.7759/cureus.4318
  16. Belousova OB, Filatov YuM, Shishkina LV, Sazonova OB. Supratentorial cavernomas: clinical features, diagnosis, treatment. Burdenko’s Journal of Neurosergery. 2003;1:3-7. (In Russ.).
  17. Verma SK, Yadav KK, Basantani N, Gupta S. Seizures: A Manifestation of Corpus Callosum Cavernoma. Indian Journal of Neurosurgery. 2016;5:183-184.  https://doi.org/10.1055/s-0036-1581979
  18. Massa-Micon B, Luparello V, Bergui M, Pagni CA. De novo cavernoma case report and review of literature. Surgical Neurology. 2000;53(5):484-487.  https://doi.org/10.1016/s0090-3019(00)00202-0
  19. Anis R, Hajer D, Mariem BM, Jamel Z, Ridha M. Cavernoma of the corpus callosum revealed by focal seizures: an exceptional presentation. Interdisciplinary Neurosurgery. 2020;04(21):100747. https://doi.org/10.1016/j.inat.2020.100747
  20. Gastaut JL, Bartolomei F. Epilepsie partielle et lésions du corps calleux [Partial epilepsy and corpus callosum involvement]. Revue Neurologique. 1993;149(6-7):416-418. (In French).
  21. Wieshmann UC, Milinis K, Paniker J, Das K, Jenkinson MD, Brodbelt A, Crooks D, Keller SS. The role of the corpus callosum in seizure spread: MRI lesion mapping in oligodendrogliomas. Epilepsy Research. 2015;109:126-133.  https://doi.org/10.1016/j.eplepsyres.2014.10.023
  22. Kopelman MD. The Korsakoff syndrome. The British Journal of Psychiatry. 1995;166(2):154-173.  https://doi.org/10.1192/bjp.166.2.154
  23. Kahn EA, Crosby EC. Korsakoff’s syndrome associated with surgical lesions involving the mammillary bodies. Neurology. 1972;22(2):117-125.  https://doi.org/10.1212/wnl.22.2.117
  24. Heilman KM, Sypert GW. Korsakoff’s syndrome resulting from bilateral fornix lesions. Neurology. 1977;27(5):490-493.  https://doi.org/10.1212/wnl.27.5.490
  25. Cole M, Winkelman MD, Morris JC, Simon JE, Boyd TA. Thalamic amnesia: Korsakoff syndrome due to left thalamic infarction. Journal of the Neurological Sciences. 1992;110(1-2):62-67.  https://doi.org/10.1016/0022-510x(92)90010-i
  26. Welch LW, Nimmerrichter A, Kessler R, King D, Hoehn R, Margolin R, Martin PR. Severe global amnesia presenting as Wernicke-Korsakoff syndrome but resulting from atypical lesions. Psychological Medicine. 1996;26(2):421-425.  https://doi.org/10.1017/s0033291700034814
  27. Yoneoka Y, Takeda N, Inoue A, Ibuchi Y, Kumagai T, Sugai T, Takeda K, Ueda K. Acute Korsakoff syndrome following mammillothalamic tract infarction. American Journal of Neuroradiology. 2004;25(6):964-968. 
  28. Mazzacane F, Ferrari F, Malvaso A, Mottese Y, Gastaldi M, Costa A, Pichiecchio A, Cavallini A. Acute amnestic syndrome in fornix lesions: a systematic review of reported cases with a focus on differential diagnosis. Frontiers in Neurology. 2024;25(15):1338291. https://doi.org/10.3389/fneur.2024.1338291
  29. Patestas MA, Gartner LP. Limbic system. In: Patestas MA, Gartner LP. A textbook of neuroanatomy. Oxford: Blackwell; 2006.
  30. Thomas AG, Koumellis P, Dineen RA. The fornix in health and disease: an imaging review. Radiographics. 2011;31(4):1107-1121. https://doi.org/10.1148/rg.314105729
  31. Matthews BR. Memory dysfunction. Behavioral Neurology and Neuropsychiatry. 2015;21(3):613-626.  https://doi.org/10.1212/01.CON.0000466656.59413.29
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.