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Stanishevskiy A.V.

Kirov Military Medical Academy

Gavrilov G.V.

Kirov Military Medical Academy;
Pavlov First Saint Petersburg State Medical University

Adleyba B.G.

Kirov Military Medical Academy

Radkov M.N.

Kirov Military Medical Academy

Svistov D.V.

Kirov Military Medical Academy

Sukhinov I.D.

Pavlov First Saint Petersburg State Medical University

Neuroimaging predictors of favorable outcomes after shunting procedures in patients with Hakim—Adams syndrome: a pilot prospective randomized trial

Authors:

Stanishevskiy A.V., Gavrilov G.V., Adleyba B.G., Radkov M.N., Svistov D.V., Sukhinov I.D.

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Journal: Burdenko's Journal of Neurosurgery. 2025;89(1): 68‑74

DOI: 10.17116/neiro20258901168

Read: 1172 times

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Table of contents

NEUROIMAGING PREDICTORS OF FAVORABLE OUTCOMES AFTER SHUNTING PROCEDURES IN PATIENTS WITH HAKIM—ADAMS SYNDROME: A PILOT PROSPECTIVE RANDOMIZED TRIAL
NEUROIMAGING PREDICTORS OF FAVORABLE OUTCOMES AFTER SHUNTING PROCEDURES IN PATIENTS WITH HAKIM—ADAMS SYNDROME: A PILOT PROSPECTIVE RANDOMIZED TRIAL

To cite this article:

Stanishevskiy AV, Gavrilov GV, Adleyba BG, Radkov MN, Svistov DV, Sukhinov ID. Neuroimaging predictors of favorable outcomes after shunting procedures in patients with Hakim—Adams syndrome: a pilot prospective randomized trial. Burdenko's Journal of Neurosurgery. 2025;89(1):68‑74. (In Russ., In Engl.)
https://doi.org/10.17116/neiro20258901168

Подписка 2025 Журнал «Вопросы нейрохирургии» имени Н.Н. Бурденко (Burdenko's Journal of Neurosurgery)
 
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

Higher effectiveness of cerebrospinal fluid shunting procedures is still an unresolved issue in the treatment of idiopathic normal pressure hydrocephalus. Thus, over 15% of patients do not experience symptom regression in postoperative period. In recent years, several MRI predictors have been actively investigated to forecast the outcomes of cerebrospinal fluid shunting procedures. We have previously introduced a prognostic model for comprehensive evaluation of MRI data facilitating identification of patients likely to benefit from surgical intervention.

OBJECTIVE

To evaluate diagnostic properties of MRI data comprehensive assessment model compared to traditional invasive diagnostic method (spinal tap test) in prospective randomized trial.

MATERIAL AND METHODS

MRI data and postoperative outcomes in patients diagnosed with idiopathic normal pressure hydrocephalus who underwent ventriculoperitoneal shunting between September 2022 and April 2024 were analyzed in prospective randomized study. In the study group, surgical decisions were based on MRI data, while the control group followed an algorithm incorporating invasive diagnostic method (spinal tap-test). Ventriculoperitoneal shunting with constant-pressure valve implantation was performed in all patients selected for surgery.

RESULTS

The study included 54 patients (25 ones in the study group and 29 ones in the control group). Surgery was performed in 21 and 20 patients, respectively. We found no advantages of invasive diagnostic methods over comprehensive assessment of MRI data in predicting the effectiveness of surgical treatment.

CONCLUSION

Comprehensive assessment of MRI findings allows for avoiding invasive diagnostic procedures in decision-making on cerebrospinal fluid shunting surgery in some patients with idiopathic normal pressure hydrocephalus.

Keywords:

idiopathic normal pressure hydrocephalus
outcome prediction
shunting procedures
tap-test
invasive diagnosis

Authors:

Stanishevskiy A.V.

Kirov Military Medical Academy

Gavrilov G.V.

Kirov Military Medical Academy;
Pavlov First Saint Petersburg State Medical University

Adleyba B.G.

Kirov Military Medical Academy

Radkov M.N.

Kirov Military Medical Academy

Svistov D.V.

Kirov Military Medical Academy

Sukhinov I.D.

Pavlov First Saint Petersburg State Medical University

Received:

30.05.2024

Accepted:

21.11.2024

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References:

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