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Turkin A.M.

Burdenko Neurosurgical Center

Melnikova-Pitskhelauri T.V.

Burdenko Neurosurgical Center

Fadeeva L.M.

Burdenko Neurosurgical Center

Kozlov A.V.

Burdenko Neurosurgical Center;
Andijan State Medical Institute

Oshorov A.V.

Burdenko Neurosurgical Center

Kravchuk A.D.

Burdenko Neurosurgical Center

Kozlova Yu.A.

Botkin Moscow City Clinical Hospital

Petryaikin A.V.

Moscow Research Practical Clinical Center for Diagnostics and Telemedicine Technologies

Ryzhova M.V.

Burdenko Neurosurgical Center

Pronin I.N.

Burdenko Neurosurgical Center

Perifocal edema and glymphatic system dysfunction: quantitative assessment based on diffusion tensor magnetic resonance imaging

Authors:

Turkin A.M., Melnikova-Pitskhelauri T.V., Fadeeva L.M., Kozlov A.V., Oshorov A.V., Kravchuk A.D., Kozlova Yu.A., Petryaikin A.V., Ryzhova M.V., Pronin I.N.

More about the authors

Journal: Burdenko's Journal of Neurosurgery. 2023;87(5): 45‑54

DOI: 10.17116/neiro20238705145

Read: 5049 times

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Table of contents

PERIFOCAL EDEMA AND GLYMPHATIC SYSTEM DYSFUNCTION: QUANTITATIVE ASSESSMENT BASED ON DIFFUSION TENSOR MAGNETIC RESONANCE IMAGING
PERIFOCAL EDEMA AND GLYMPHATIC SYSTEM DYSFUNCTION: QUANTITATIVE ASSESSMENT BASED ON DIFFUSION TENSOR MAGNETIC RESONANCE IMAGING

To cite this article:

Turkin AM, Melnikova-Pitskhelauri TV, Fadeeva LM, et al. Perifocal edema and glymphatic system dysfunction: quantitative assessment based on diffusion tensor magnetic resonance imaging. Burdenko's Journal of Neurosurgery. 2023;87(5):45‑54. (In Russ., In Engl.)
https://doi.org/10.17116/neiro20238705145

Подписка 2025 Журнал «Вопросы нейрохирургии» имени Н.Н. Бурденко (Burdenko's Journal of Neurosurgery)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

BACKGROUND

Pathogenesis of peritumoral cerebral edema is unclear and potentially associated with glymphatic system dysfunction. Diffusion tensor MRI (DT-MRI) with analysis of ALPS (Analysis along the Perivascular Space) index may be valuable for assessment of edema. This approach visualizes fluid flow along perivascular spaces of deep cerebral veins.

OBJECTIVE

To assess glymphatic system function in supratentorial tumors and healthy volunteers using DT-MRI.

MATERIAL AND METHODS

There were 52 patients (59% men) aged 43 (28—64) years with supratentorial tumors (meningioma — 20, grade 3—4 glioma — 15, metastases — 9, lymphoma — 8). Tumors and perifocal edema did not involve deep cerebral veins. The control group included 6 healthy volunteers aged 34-66 years. MRI protocol (Signa HDxt, 3 T) contained standard T1, T2, T2FLAIR, DWI and post-contrast T1 (3D BRAVO). DT-MRI had the following parameters: TR=10 000 ms, TEmin=102 ms, FOV=240 mm, isotropic voxel size 3×3×3 mm3, 60 directions of diffusion gradients. Measurements were carried out at b-factor 0 and 1000 s/mm2. Analysis was carried out in the ReadyView software.

RESULTS

Right- and left-sided ALPS indices were similar in the control group (p=0.917). Perifocal edema (regardless of histological type of tumor) in the ipsilateral hemisphere was accompanied by significantly lower ALPS index (p<0.005), while these values in contralateral (intact) hemisphere were similar in both groups (p=0.7).

CONCLUSION

We found significantly lower ALPS index in deep parts of the affected hemisphere in patients with perifocal edema. These data can indicate the role of glymphatic system dysfunction in pathogenesis of this pathology.

Keywords:

perifocal edema
meningiomas
metastases
gliomas
lymphomas
diffusion tensor MRI
ALPS index

Authors:

Turkin A.M.

Burdenko Neurosurgical Center

Melnikova-Pitskhelauri T.V.

Burdenko Neurosurgical Center

Fadeeva L.M.

Burdenko Neurosurgical Center

Kozlov A.V.

Burdenko Neurosurgical Center;
Andijan State Medical Institute

Oshorov A.V.

Burdenko Neurosurgical Center

Kravchuk A.D.

Burdenko Neurosurgical Center

Kozlova Yu.A.

Botkin Moscow City Clinical Hospital

Petryaikin A.V.

Moscow Research Practical Clinical Center for Diagnostics and Telemedicine Technologies

Ryzhova M.V.

Burdenko Neurosurgical Center

Pronin I.N.

Burdenko Neurosurgical Center

Received:

15.06.2023

Accepted:

13.07.2023

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