Application of autologous fibrin glue for skull base defect closure in transsphenoidal surgery. Case report and literature review

Sharipov O.I.

N.N. Burdenko National Medical Research Center of Neurosurgery of the Ministry of Health of the Russian Federation

ORCID: 0000-0003-3777-5662

Kvan O.K.

Burdenko Neurosurgical Center

ORCID: 0000-0002-6147-7887

Kutin M.A.

Burdenko Neurosurgery Center

Donskoy A.D.

Burdenko Neurosurgical Center

Kalinin P.L.

Burdenko Neurosurgery Center

Application of autologous fibrin glue for skull base defect closure in transsphenoidal surgery. Case report and literature review

Authors:

Sharipov O.I., Kvan O.K., Kutin M.A., Donskoy A.D., Kalinin P.L.

More about the authors

Journal: Burdenko's Journal of Neurosurgery. 2022;86(5): 89‑95

DOI: 10.17116/neiro20228605189

Downloaded: 123

To cite this article:

Sharipov OI, Kvan OK, Kutin MA, Donskoy AD, Kalinin PL. Application of autologous fibrin glue for skull base defect closure in transsphenoidal surgery. Case report and literature review. Burdenko's Journal of Neurosurgery. 2022;86(5):89‑95. (In Russ., In Engl.)
https://doi.org/10.17116/neiro20228605189

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Nasal CSF leakage is the most common complication after transsphenoidal surgery, especially in case of extended transsphenoidal access. It is one of the main and obvious risk factors of meningitis. Introduction of effective reconstructive techniques made it possible to reduce the incidence of postoperative CSF leakage. Fibrin glue is one of the main components in transsphenoidal surgery for skull base defect closure. The use of autologous fibrin glue excludes immune response due to its biocompatibility. Modern technologies of preparation of autologous fibrin glue make it possible to obtain a large volume of glue that ensures complete sealing of skull base defect. At the same time, autologous glue contains factors promoting rapid tissue regeneration. It is of great importance for engraftment of autologous transplants in the area of skull base defect.

Keywords:

endoscopic transsphenoidal approach

CSF leak

autologous fibrin glue

Authors:

Sharipov O.I.

N.N. Burdenko National Medical Research Center of Neurosurgery of the Ministry of Health of the Russian Federation

ORCID: 0000-0003-3777-5662

Kvan O.K.

Burdenko Neurosurgical Center

ORCID: 0000-0002-6147-7887

Kutin M.A.

Burdenko Neurosurgery Center

Donskoy A.D.

Burdenko Neurosurgical Center

Kalinin P.L.

Burdenko Neurosurgery Center

Received:

16.03.2022

Accepted:

19.08.2022

List of references:

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