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Gersamia A.G.

Moscow Research and Clinical Center for Neuropsychiatry

Pochigaeva K.I.

Moscow Research and Clinical Center for Neuropsychiatry

Less Yu.E.

Moscow Research and Clinical Center for Neuropsychiatry

Akzhigitov R.G.

Moscow Research and Clinical Center for Neuropsychiatry

Guekht A.B.

Moscow Research and Clinical Center for Neuropsychiatry;
Pirogov Russian National Research Medical University

Gulyaeva N.V.

Institute of Higher Nervous Activity and Neurophysiology of RAS

Gender characteristics of depressive disorders: clinical, psychological, neurobiological and translational aspects

Authors:

Gersamia A.G., Pochigaeva K.I., Less Yu.E., Akzhigitov R.G., Guekht A.B., Gulyaeva N.V.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2024;124(3): 7‑16

DOI: 10.17116/jnevro20241240317

Read: 2915 times

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Table of contents

GENDER CHARACTERISTICS OF DEPRESSIVE DISORDERS: CLINICAL, PSYCHOLOGICAL, NEUROBIOLOGICAL AND TRANSLATIONAL ASPECTS
GENDER CHARACTERISTICS OF DEPRESSIVE DISORDERS: CLINICAL, PSYCHOLOGICAL, NEUROBIOLOGICAL AND TRANSLATIONAL ASPECTS

To cite this article:

Gersamia AG, Pochigaeva KI, Less YuE, Akzhigitov RG, Guekht AB, Gulyaeva NV. Gender characteristics of depressive disorders: clinical, psychological, neurobiological and translational aspects. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;124(3):7‑16. (In Russ.)
https://doi.org/10.17116/jnevro20241240317

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

Various studies have indicated that the prevalence of depression is almost twice as high among women as among men. A major factor associated with the development of depression and other affective disorders are adverse and psychologically traumatic life events that contribute to changes in the neuroendocrine system, altering the capacity to adapt to stress. These changes are involved in the pathogenesis of mental disorders, along with genetic and other factors, and are to a significant degree regulated by gender dependent mechanisms. While women have a high prevalence of depressive disorders, men show a higher rate of alcohol and substance abuse. These differences in the epidemiology are most likely explained by different predisposition to mental disorders in men and women and a diversity of biological consequences to adverse life events. Taking this into account, there is a need for a critical review of currently used approaches to modeling depressive disorders in preclinical studies, including the use of animals of both sexes. Adaptation of experimental models and protocols taking into account gender characteristics of neuroendocrine changes in response to stress, as well as structural-morphological, electrophysiological, molecular, genetic and epigenetic features, will significantly increase the translational validity of experimental work.

Keywords:

depressive disorder
gender aspects
clinical psychology
neurobiology

Authors:

Gersamia A.G.

Moscow Research and Clinical Center for Neuropsychiatry

Pochigaeva K.I.

Moscow Research and Clinical Center for Neuropsychiatry

Less Yu.E.

Moscow Research and Clinical Center for Neuropsychiatry

Akzhigitov R.G.

Moscow Research and Clinical Center for Neuropsychiatry

Guekht A.B.

Moscow Research and Clinical Center for Neuropsychiatry;
Pirogov Russian National Research Medical University

Gulyaeva N.V.

Institute of Higher Nervous Activity and Neurophysiology of RAS

Received:

09.10.2023

Accepted:

10.10.2023

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