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Antonen E.G.

Petrozavodsk State University

Kruchek M.M.

Petrozavodsk State University

Nikitina M.V.

Russian Railways-Medicine Clinical Hospital

Evaluation of the effectiveness of treatment of patients with nonspecific pain syndrome in the lower back with celecoxib and a combined preparation of B vitamins

Authors:

Antonen E.G., Kruchek M.M., Nikitina M.V.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2022;122(8): 65‑72

DOI: 10.17116/jnevro202212208165

Read: 3588 times

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Table of contents

EVALUATION OF THE EFFECTIVENESS OF TREATMENT OF PATIENTS WITH NONSPECIFIC PAIN SYNDROME IN THE LOWER BACK WITH CELECOXIB AND A COMBINED PREPARATION OF B VITAMINS
EVALUATION OF THE EFFECTIVENESS OF TREATMENT OF PATIENTS WITH NONSPECIFIC PAIN SYNDROME IN THE LOWER BACK WITH CELECOXIB AND A COMBINED PREPARATION OF B VITAMINS

To cite this article:

Antonen EG, Kruchek MM, Nikitina MV. Evaluation of the effectiveness of treatment of patients with nonspecific pain syndrome in the lower back with celecoxib and a combined preparation of B vitamins. S.S. Korsakov Journal of Neurology and Psychiatry. 2022;122(8):65‑72. (In Russ.)
https://doi.org/10.17116/jnevro202212208165

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

OBJECTIVE

To evaluate the effectiveness of the effect of celecoxib and the combined vitamin complex of group B in comparison with meloxicam in patients with acute and chronic nonspecific lumbar pain (LP).

MATERIAL AND METHODS

The effectiveness of the effect on acute (44%; acute pain syndrome (APS)) and chronic (56%; chronic pain syndrome (CPS)) LP of moderate intensity (according to VAS/MPQ) (APS 5.7±2.3/2.13±0.67 points; CPS 5.2±2.8/1.47±0.61 points), the leading component of which is sensory sensations (when APS is lower than in CBS; Kr-W=6.15, p=0.04) and affective disorders in CPS (U=117.5, p=0.04) celecoxib without (APS 25%; CPS 75%) and with the addition of Neuromultivit (APS 36%; CPS 64%) and in comparison with meloxicam (APS 100%) against the background of basic therapy in 93 patients (61.3% women and 38.7% men; average age 49.9±9. years) with nonspecific LP pain syndrome in the lower back, with a low degree of severity of motor function (MF) disorders according to the ICF (2±1 points), due to spondyloarthrosis of the lumbosacral spine.

RESULTS

It was found that celecoxib and meloxicam cause the same significant remitting decrease in the severity of APS and restoration of MF disorders in patients with APS, equally cause rare adverse events (gastropathy, increased blood pressure) in comorbid pathology. Celecoxib proved to be more effective in relieving CPS and improving MF (p<0.05), and the combination of celecoxib with Neuromultivit caused more pronounced relief of APS and CPS, restoration of MF (p<0.01). A steady decrease in the intensity of PS (1-2 points according to VAS), recovery of MF occurs only on the 10th-11th day of therapy (p<0.01), with complete relief of LP by day 21 only in 60.22% of cases.

CONCLUSION

The results of the study confirm the benefits of celecoxib in combination with a vitamin complex for the relief of CPS.

Keywords:

acute and chronic pain
celecoxib
B vitamins
Neuromultivit

Authors:

Antonen E.G.

Petrozavodsk State University

Kruchek M.M.

Petrozavodsk State University

Nikitina M.V.

Russian Railways-Medicine Clinical Hospital

Received:

04.07.2022

Accepted:

08.07.2022

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References:

  1. Nasonov EL, ed. Rossijskie klinicheskie rekomendatsii. Revmatologiya. M.: GEOTAR-Media; 2017:464. (In Russ.).
  2. Voznyuk KO, Churyukanov MV. Features of injection therapy of acute musculoskeletal pain at the primary level. Russian Journal of Pain. 2019;17(S1): 164-165. (In Russ.).
  3. Kovalchuk VV, Amanova E O, Galkin AS, et al. Combined drugs: the possibility of improving the effectiveness and safety of traditional therapy of back pain. Effektivnaya farmakoterapiya. 2017;19:80-88. (In Russ.).
  4. Strokov IA, Drokonova OO, Akhmedzhanova LT. Combination therapy of back pain with B vitamins and nonsteroidal anti-inflammatory drugs. Medical Council. 2013;12:34-37. (In Russ.).
  5. Vorobyeva OV. Chronic back pain: from pathogenetic concepts to therapeutic strategies. Medical Council. 2017;17:36-42. (In Russ.). https://doi.org/10.21518/2079-70/X-2017-17-36-42
  6. Barinov AN, Rozhkov DO, Makhinov KA. Treatment of nonspecific back pain. RMZh. 2017;25(21):1553-1560. (In Russ.).
  7. Kastro IV, Popadyuk VI, Blagonravov ML, et al. McGill’s pain questionnaire as a method for determining the level of pain syndrome in patients after rinoseptoplasty and nasal polypotomy. Acta Biomedica Scientifica. 2012; 4-2(86):68-71. (In Russ.).
  8. Tsykunov MB. Assessment of disorders in the pathology of the musculoskeletal system using the categories of the international classification of functioning. Fizicheskaya i reabilitatsionnaya meditsina. 2019;1(2):37-59. (In Russ.). https://doi.org/10.26211/2658-4522-2019-1-2-37-59
  9. Castellsague J, Riera-Guardia N, Calingaert B, et al. Safety of Non-Steroidal Anti-Inflammatory Drugs (SOS) Project. Individual NSAIDs and upper gastrointestinal complications: a systematic review and meta-analysis of observational studies (the SOS project). Drug Saf. 2012;35(12):1127-1146. https://doi.org/10.2165/11633470-000000000-00000
  10. Chan FKL, Ching JYL, Tse YK, et al. Gastrointestinal safety of celecoxib versus naproxen in patients with cardiothrombotic diseases and arthritis after upper gastrointestinal bleeding (CONCERN): An industry-independent, double-blind, double-dummy, randomised trial. Lancet. 2017;389(10087):2375-2382. https://doi.org/10.1016/S0140-6736(17)30981-9
  11. Nissen SE, Yeomans ND, Solomon DH, et al. Cardiovascular Safety of Celecoxib, Naproxen, or Ibuprofen for Arthritis. N Engl J Med. 2016;375(26): 2519-29.  https://doi.org/10.1056/NEJMoa1611593
  12. Parfenov VA, Isaikin AI, Kuzminova TI, et al. Treatment of patients with acute and subacute lumbalgia and lumboishialgia. Nevrologiya, nejropsikhiatriya, psihosomatika. 2019;11(3):57-62. (In Russ.). https://doi.org/10.14412/2074-2711-2019-3-57-62
  13. Theodoridou A, Gika H, Diza E, et al. In vivo study of pro-inflammatory cytokine changes in serum and synovial fluid during treatment with celecoxib and etoricoxib and correlation with VAS pain change and synovial membrane penetration index in patients with inflammatory arthritis. Mediterr J Rheumatol. 20178;28(1):33-40.  https://doi.org/10.31138/mjr.28.1.33
  14. Calderón-Ospina CA, Nava-Mesa MOB. Vitamins in the nervous system: Current knowledge of the biochemical modes f action and synergies of thiamine, pyridoxine, and cobalamin. CNS Neurosci Ther. 2020;26(1):5-13.  https://doi.org/10.1111/cns.13207
  15. Voznyuk KO, Churyukanov MV, Bakhtadze MA. Comparison of the painfulness of injections of B vitamins containing and not containing lidocaine. Russian Journal of Pain. 2020;18:3:20-24. (In Russ.). https://doi.org/10.17116/pain20201803120
  16. Khabirov FA, Khaybullin TI, Granatov EV. Efficacy and safety of Neuromultivitis in vertebrogenic radiculopathies. Zhurnal nevrologii i psihiatrii imeni S.S. Korsakova. 2017;117(10):38-43. (In Russ.). https://doi.org/10.17116/jnevro201711710138-43
  17. Kukushkin ML. Algorithms for diagnosis and treatment of back pain. Russkij meditsinskij zhurnal. 2014;(11):844-8 (In Russ.).
  18. Aw T, Haas S, Liew D, Krum H. Meta-analysis of cyclooxyge nase-2 inhibitors and their effects on blood pressure. Arch Intern Med. 2005;165(5): 490-496.  https://doi.org/10.1001/archinte.165.5.ioi50013
  19. Wilner KD, Rushing M, Walden C, et al. Celecoxib does not affect the antiplatelet activity of aspirin in healthe volunteers. J Clin Pharmacol. 2002;42(9):1027-1030. https://doi.org/10.1177/0091270002042009010
  20. Van RJ, Kink-Eiband M, Kuritsch I, et al. Meloxicam does not affect the antiplatelet effect of aspirin in healthy male and female volunteers. J Clin Pharmacol. 2004;44(7):777-784.  https://doi.org/10.1177/0091270004266623
  21. Mitchell JA, Kirkby NS. Eicosanoids, prostacyclin and cyclooxygenase in the cardiovascular system. Br J Pharmacol. 2018;12(5):34-39.  https://doi.org/10.1111/bph.14167
  22. Harirforoosh S, Asghar W, Jamali F. Adverse Effects of Nonsteroidal Antiinflammatory Drugs: An Update of Gastrointestinal, Cardiovascular and Renal Complications. J Pharm Pharm Sci. 2013;16(5):821-847.  https://doi.org/10.18433/J3VW2F
  23. Karateev AE, Lila AM, Churyukanov MV, et al. Evaluation of algorithm efficiency prescribing nonsteroidal anti-inflammatory drugs (NSAIDs) based on the analysis of risk factors for drug complications in real clinical practice. Results of the All-Russian project “PRINCIPLE” (Application of Recommendations on the Use of NSAIDs: Purposeful Change of Practice). Nauchno-prakticheskaya revmatologiya. 2017;55(5):485-492. (In Russ.). https://doi.org/10.14412/1995-4484-2017-485-492
  24. Chan CC, Reid C, Aw T, et al. Do COX-2 inhibitors raise blood pressure more than nonselective NSAIDs and placebo? An updated meta-analysis. J Hypertens. 2009;27(12):2332-2341. https://doi.org/10.1097/HJH.0b013e3283310dc9
  25. Kukushkin ML. Diagnosis and treatment of nonspecific back pain. Medical Council. 2016;(8):58-63. (In Russ.). https://doi.org/10.21518/2079-701X-2016-8-58-63
  26. Kuritzky L, Samraj GP. Nonsteroidal anti-inflammatory drugs in the treatment of low back pain. J Pain Res. 2012;5:579-590.  https://doi.org/10.2147/JPR.S6775
  27. White AP, Arnold PM, Norvell DC, et al. Pharmacologic management of chronic low back pain: synthesis of the evidence. Spine (Phila Pa 1976). 2011;36(21 Suppl):131-143.  https://doi.org/10.1097/BRS.0b013e31822f178f
  28. Vakhnina NV. Chronic lumbosacral pain: diagnosis and treatment (lecture). Clinical Medicine. 2010;3:30-34. (In Russ.).
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