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Tkach A.V.

Vernadsky Crimean Federal University

Kutia S.A.

Vernadsky Crimean Federal University

Tkach V.V.

Vernadsky Crimean Federal University

Moroz G.A.

Georgievsky Medical Academy of the Vernadsky Crimean Federal University

Modern ideas on trigeminal ganglion

Authors:

Tkach A.V., Kutia S.A., Tkach V.V., Moroz G.A.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2022;122(12): 143‑147

DOI: 10.17116/jnevro2022122121143

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Table of contents

MODERN IDEAS ON TRIGEMINAL GANGLION
MODERN IDEAS ON TRIGEMINAL GANGLION

To cite this article:

Tkach AV, Kutia SA, Tkach VV, Moroz GA. Modern ideas on trigeminal ganglion. S.S. Korsakov Journal of Neurology and Psychiatry. 2022;122(12):143‑147. (In Russ.)
https://doi.org/10.17116/jnevro2022122121143

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

The article summarizes data about the structural and functional organization of the sensory ganglion of V cranial nerve — trigeminal, or Gassesrian, ganglion. Information about its discovery, embryonic development, anatomy and topography, features of cyto- and histoarchitectonics are given, the role of neurotransmitters of trigeminal ganglion neurons in nociception mechanisms is reflected, the functional significance of the trigeminal system and clinical aspects of the lesion of the Gasserian ganglion are described.

Keywords:

trigeminal node
clinical anatomy
trigeminal system
nociception

Authors:

Tkach A.V.

Vernadsky Crimean Federal University

Kutia S.A.

Vernadsky Crimean Federal University

Tkach V.V.

Vernadsky Crimean Federal University

Moroz G.A.

Georgievsky Medical Academy of the Vernadsky Crimean Federal University

Received:

04.07.2022

Accepted:

21.07.2022

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References:

  1. Karlov VA. Facial pain. Zhurnal Nevrologii i Psihiatrii im. S.S. Korsakova. 2010;110(5):90-100. (In Russ.).
  2. Larrier D, Lee A. Anatomy of headache and facial pain. Otolaryngol Clin N Am. 2003;36(6):1041-1053. https://doi.org/10.1016/S0030-6665(03)00127-0
  3. Evers S. Facial pain: overlapping syndromes. Cephalalgia. 2017;37(7):705-713.  https://doi.org/10.1177/0333102417703761
  4. Kutia SA, Nikolaeva NG, Moroz GA, et al. The history of the discovery of Gasserian ganglion. Zhurnal Nevrologii i Psihiatrii im. S.S. Korsakova. 2019;119(10):62-66. (In Russ.). https://doi.org/10.17116/jnevro201911910162
  5. Sadler TW. Embryology of neural tube development. American Journal of Medical Genetics Part C. 2005;135:2-8.  https://doi.org/10.1002/ajmg.c.30049
  6. Lawson A. Cellular mechanisms of neural fold formation and morphogenesis in the chick embryo. The Anatomical Record. 2001;262:153-168. https://doi.org/10.1002/1097-0185(20010201)262:2<153::AID-AR1021>3.0.CO;2-W "> 3.0.CO;2-W" target="_blank">https://doi.org/10.1002/1097-0185(20010201)262:2<153::AID-AR1021>3.0.CO;2-W
  7. Sato SM, Sargent TD. Development of neural inducing capacity in dissociated Xenopus embryos. Development Biology. 1998;134:263-266.  https://doi.org/10.1016/0012-1606(89)90096-1
  8. Kehrli P, Maillot C, Wolff MJ. Anatomy and embryology of the trigeminal nerve and its branches in the parasellar area. Neurol Res. 1997;19(I):57-65.  https://doi.org/10.1080/01616412.1997.11740773
  9. Dechko VM. Development of cranial nerves and parasympathetic ganglions in embryogenesis. Dostizheniya i Innovacii v Sovremennoj Morfologii. Minsk: Publishing House Belarusian State Medical University. 2016;130-132. (In Russ.).
  10. Nolte J. The human brain: an introduction to its functional anatomy. St. Louis: London: Mosby; 2002.
  11. Snell RS. Clinical neuroanatomy. Lippincott Williams & Wilkins; 2010.
  12. Binder DK, Zonne N, Fishbajn Dzh. Cranial nerves: anatomy, pathology, visualization. Pod red. Kamchatnova P.R. M.: MEDpress-inform; 2014. (In Russ.).
  13. Zyal IM, Sekhar LN, Ozgern T, et al. The trigeminal nerve and ganglion: An anatomical, histological and radiological study addressing the trigeminal approach. Surgical Neurology. 2004;61:564-574.  https://doi.org/10.1016/j.surneu.2003.07.009
  14. Sudarikova TV, Uryvaev MYu, Cybul’kin AG, et al. Correlations of the size, shape, and location of the trigeminal ganglion in an adults. Fundamental’nye Issledovaniya. 2006;2:68. (In Russ.).
  15. Sudarikova TV, Trufanov IN, Gorskaya TV, et al. Typical, gender and age features of human trigeminal ganglion topography. Uspekhi Sovremennogo Estestvoznaniya. 2006;3:53-54. (In Russ.).
  16. Penteshina NA. Some issues of the features of the topography of the Gasserian ganglion as applied to practice. Zapiski 1-go Leningradskogo med. In-ta. 1959;3:210-218. (In Russ.).
  17. Semenov KV. Some issues of typical and surgical anatomy of the semilunar ganglion of the trigeminal nerve. Hirurgiya. 1938;1:8-25. (In Russ.).
  18. Yousry I, Moriggl B, Holtmannspoetter M, et al. Detailed anatomy of the motor and sensor root of the trigeminal nerve and their neurovascular relationships: a magnetic resonance images study. J Neurosurgery. 200;101:427-434.  https://doi.org/10.3171/jns.2004.101.3.0427
  19. Chekhonackij AA, Ushakov DA. Paracentetic access to sensory root of trigeminus: anatomic and topographic features (review). Saratovskij Nauchno-Medicinskij Zhurnal. 2012;8(3):785-790. (In Russ.).
  20. LaGuardia JJ, Cohrs RJ, Gilden DH. Numbers of neurons and non-neuronal cells in human trigeminal ganglia. Neurol Res. 2000;22:565-566.  https://doi.org/10.1080/01616412.2000.11740719
  21. Thalakoti S, Patil VV, Damodaram S, et al. Neuron-glia signaling in trigeminal ganglion: implications for migraine pathology. Headache. 2007;47(7):1008-1023. https://doi.org/10.1111/j.1526-4610.2007.00854.x
  22. Pennisi E, Cruccu G, Manfredi M, Palladini G. Histometric study of myelinated fibers in the human trigeminal nerve. J Neurol Sci. 1991;105(1):22-28.  https://doi.org/10.1016/0022-510x(91)90113-l
  23. Rusu MC, Cretoiu D, Vrapciu AD, et al. Telocytes of the human adult trigeminal ganglion. Cell Biol Toxicol. 2016;32(3):199-207.  https://doi.org/10.1007/s10565-016-9328-y
  24. Haribova EA. Peculiarities of angioarchitectonics of human trigeminal ganglion depending on the organization of structural-territorial neuro-glial ensembles. Morfologiya. 2014;145(3):206. (In Russ.).
  25. Krastev D, Paloff A, Hinova-Palova D, et al. Light- microscopic structure of trigeminal ganglion in humans. Ann Proc J IMAB. 2007;1:111-113. 
  26. Krastev D, Paloff A, Krastev N, et al. Ultrastructure of trigeminal ganglion in human. Ann Proc J IMAB. 2008;1:36-39. 
  27. Piovesan EJ, Kowacs PA, Oshinsky ML. Convergence of cervical and trigeminal sensory afferents. Curr Pain Headache Rep. 2003;(5):377-383.  https://doi.org/10.1007/s11916-003-0037-x
  28. Messlinger K, Balcziak LK, Russo AF. Cross talk signaling in the trigeminal ganglion: role of neuropeptides and other mediators. Journal of Neural Transmission. 2020;127:431-444.  https://doi.org/10.1007/s00702-020-02161-7
  29. Eftekhari S, Salvatore CA, Calamari A, et al. Differential distribution of calcitonin gene-related peptide and its receptor components in the human trigeminal ganglion. Neuroscience. 2010;169(2):683-696.  https://doi.org/10.1016/j.neuroscience.2010.05.016
  30. Iyengar S, Johnson KW, Ossipov MH, Aurora SK. CGRP and the Trigeminal System in Migraine. Headache. 2019;59(5):659-681.  https://doi.org/10.1111/head.13529
  31. Edvinsson L, Haanes KA, Warfvinge K, Krause DN. CGRP as the target of new migraine therapies — successful translation from bench to clinic. Nat Rev Neurol. 2018;14(6):338-350.  https://doi.org/10.1038/s41582-018-0003-1
  32. Solov’ev VB. Neuropeptides: structural and functional classification. Actual Science. 2015;1(4):22-35. (In Russ.).
  33. Ashina H, Schytz HW, Ashina M. CGRP in human models of primary headaches. Cephalalgia. Int J Headache. 2018;38:353-360.  https://doi.org/10.1177/0333102416684344
  34. Riesco N, Cernuda-Morollón E, Pascual J. Neuropeptides as amarker for chronic headache. Curr Pain Headache Rep. 2017;21:18.  https://doi.org/10.1007/s11916-017-0618-8
  35. Tajti J, Szok D, Majláth Z, et al. Migraine and neuropeptides. Neuropeptides. 2015;52:19-30.  https://doi.org/10.1016/j.npep.2015.03.006
  36. Goadsby PJ, Edvinsson L, Ekman R. Release of vasoactive peptides in the extracerebral circulation of humans and the cat during activation of the trigeminovascular system. Ann Neurol. 1988;23(2):193-196.  https://doi.org/10.1002/ana.410230214
  37. Goadsby PJ, Edvinsson L, Ekman R. Vasoactive peptide release in the extracerebral circulation of humans during migraine headache. Ann Neurol. 1990;28(2):183-187.  https://doi.org/10.1002/ana.410280213
  38. Kuznecova EA, YAkupov EZ. Neurophysiological assessment of afferent-efferent interaction in the trigeminal-cervical system in patients with secondary headaches. Zhurnal Nevrologii i Psihiatrii im. S.S. Korsakova. 2011;111(10):54-57. (In Russ.).
  39. Messlinger K, Russo AF. Current understanding of trigeminal ganglion structure and function in headache. Cephalalgia. 2019;39(13):1661-1674. https://doi.org/10.1177/0333102418786261
  40. Weinberg JM. Herpes zoster: epidemiology, natural history, and common complications. J Am Acad Dermatol. 2007;57(6):130-135.  https://doi.org/10.1016/j.jaad.2007.08.046
  41. Carbone V, Leonardi A, Pavese M, et al. Herpes zoster of the trigeminal nerve; a case report and review of literature. Minerva Stomatol. 2004;53(1-2):49-59. 
  42. Lebedev IA, Kicherova OA, Aslapovskaya AO, et al. Facial ganglia. Anatomy and symptomatology of lesions. Medicinskij Alfavit. 2016;14(277):22-27. (In Russ.).
  43. Duus’ Topical Diagnosis in Neurology: Anatomy, Physiology, Signs, Symptoms. 5th edition — By M. Baehr, M. Frotscher. Thieme. 2012.
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