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Durnev A.D.

Zakusov Research Institute of Pharmacology

Eremina N.V.

Zakusov Research Institute of Pharmacology

Zhanataev A.K.

Zakusov Research Institute of Pharmacology

Kolik L.G.

Zakusov Research Institute of Pharmacology

Genotoxicity of psychotropic drugs in experimental and clinical studies

Authors:

Durnev A.D., Eremina N.V., Zhanataev A.K., Kolik L.G.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2022;122(10): 7‑16

DOI: 10.17116/jnevro20221221017

Read: 4614 times

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Table of contents

GENOTOXICITY OF PSYCHOTROPIC DRUGS IN EXPERIMENTAL AND CLINICAL STUDIES
GENOTOXICITY OF PSYCHOTROPIC DRUGS IN EXPERIMENTAL AND CLINICAL STUDIES

To cite this article:

Durnev AD, Eremina NV, Zhanataev AK, Kolik LG. Genotoxicity of psychotropic drugs in experimental and clinical studies. S.S. Korsakov Journal of Neurology and Psychiatry. 2022;122(10):7‑16. (In Russ.)
https://doi.org/10.17116/jnevro20221221017

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

The analysis of experimental data on the study of the genotoxic activity of psychotropic drugs published over the past 25 years has been carried out. It has been shown that the information describing the genotoxicity of psychotropic drugs is characterized by fragmentation, contradictions, and the conditions for their experimental production often do not meet modern requirements. Conclusions about the presence or absence of genotoxic properties can be made only for 9.6% 94 examined drugs. The need for a large-scale systematic reassessment of the genotoxicity of psychotropic drugs, especially drugs of the first generation, on the basis of modern methodology, including studies of mutagen-modifying activity, has been proven. The expediency of monitoring the genotoxic status of patients receiving psychotropic drugs is emphasized, which should contribute to an adequate assessment of the genotoxic risk of their use and objectification of approaches when choosing a drug for the safe therapy. The urgency of conducting research to determine the role of primary DNA damage in the pathogenesis of mental illnesses has been substantiated.

Keywords:

psychotropic drugs
chromosomal aberrations
micronuclei
DNA comet assay
DNA damage
genotoxicity

Authors:

Durnev A.D.

Zakusov Research Institute of Pharmacology

Eremina N.V.

Zakusov Research Institute of Pharmacology

Zhanataev A.K.

Zakusov Research Institute of Pharmacology

Kolik L.G.

Zakusov Research Institute of Pharmacology

Received:

13.11.2021

Accepted:

27.07.2022

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References:

  1. Durnev AD, Zhanataev AK, Shreder OV, et al. Genotoksicheskie porazheniya i bolezni. Molekulyarnaya meditsina. 2013;3:3-19. (In Russ.).
  2. Houdhuri S, Kaur T, Jain S, et al. A review on genotoxicity in connection to infertility and cancer. Chem Biol Interact. 2021;345:109531. https://doi.org/10.1016/j.cbi.2021.109531
  3. Verdoux H, Tournier M, Bégaud B. Antipsychotic prescribing trends: a review of pharmaco-epidemiological studies. Acta Psychiatr Scand. 2010;121(1):4-10.  https://doi.org/10.1111/j.1600-0447.2009.01425.x
  4. Verdoux H, Tournier M, Bégaud B. Pharmacoepidemiology of psychotropic drugs: examples of current research challenges on major public health issues. Epidemiol Psichiatr Soc. 2009;18(2):107-113. 
  5. Patten SB, Waheed W, Bresee L. A review of pharmacoepidemiologic studies of antipsychotic use in children and adolescents. Can J Psychiatry. 2012;57(12):717-721.  https://doi.org/10.1177/070674371205701202
  6. Filippova LM, Rapoport NA, Shapiro YuL, Aleksandrovskii YuA. Mutagennaya aktivnost’ psikhotropnykh preparatov. Genetika. 1975;11(6):77-88. (In Russ.).
  7. OECD Guidelines for the Testing of Chemicals, Section 4. Health Effects. https://www.oecd-ilibrary.org/environment/oecd-guidelines-for-the-testing-of-chemicals-section-4-health-effects_20745788
  8. Steiblen G, Benthem J, Johnson G. Strategies in genotoxicology: Acceptance of innovative scientific methods in a regulatory context and from an industrial perspective. Mutation Research — Genetic Toxicology and Environmental Mutagenesis. 2020;853:503171  https://doi.org/10.1016/j.mrgentox.2020.503171
  9. National Library of Medicine. Accessed May 29, 2022. https://www.ncbi.nlm.nih.gov/PubMed
  10. Scientific electronic library. Accessed: May 29, 2022. https://elibrary.ru
  11. Vidal Medicines Handbook. Anatomical-Therapeutic-Chemical (ATC) classification system. Accessed: May 29, 2022. https://www.vidal.ru/drugs/atc
  12. Vidal Medicines Handbook. Nosological index. Accessed May 29, 2022. https://www.vidal.ru/drugs/nosology
  13. Mironov AN, Bunatyan ND, et al. Guidelines for conducting preclinical drug trials funds. Part 1. M.: Grif i K; 2012:944. 
  14. Takasawa H, Suzuki H, Ogawa I. Evaluation of a liver micronucleus assay in young rats (III): a study using nine hepatotoxicants by the Collaborative Study Group for the Micronucleus Test (CSGMT)/Japanese Environmental Mutagen Society (JEMS)-Mammalian Mutagenicity Study Group (MMS). Mutat Res. 2010;698(1-2):30-37.  https://doi.org/10.1016/j.mrgentox.2010.02.009
  15. Asanami S, Shimono K, Kaneda S. Transient hypothermia induces micronuclei in mice. Mutat Res. 1998;413(1):7-14.  https://doi.org/10.1016/s1383-5718(98)00004-7
  16. Guzmán A, García C, Marín AP, et al. Formation of micronucleated erythrocytes in mouse bone-marrow under conditions of hypothermia is not associated with stimulation of erythropoiesis. Mutat Res. 2008;656(1-2):8-13.  https://doi.org/10.1016/j.mrgentox.2008.06.016
  17. Asanami S, Shimono K. Effects of chemically- and environmentally-induced hypothermia on micronucleus induction in rats. Mutat Res. 2000;471(1-2):81-86.  https://doi.org/10.1016/s1383-5718(00)00119-4
  18. Struwe M, Greulich KO, Junker U, et al. Detection of photogenotoxicity in skin and eye in rat with the photo comet assay. Photochem Photobiol Sci. 2008;7(2):240-249.  https://doi.org/10.1039/b715756h
  19. Agúndez JAG, García-Martín E, García-Lainez G, Miranda MA, Andreu I. Photomutagenicity of chlorpromazine and its N-demethylated metabolites assessed by NGS. Sci Rep. 2020;10(1):6879. https://doi.org/10.1038/s41598-020-63651-y
  20. Kersten B, Zhang J, Brendler-Schwaab SY, Kasper P, Müller L. The application of the micronucleus test in Chinese hamster V79 cells to detect drug-induced photogenotoxicity. Mutat Res. 1999;445(1):55-71.  https://doi.org/10.1016/s1383-5718(99)00143-6
  21. Rao KP, Rao MS. Effects of fluphenazine hydrochloride on the bone-marrow cells of Swiss mice. Mutat Res. 1981;89(3):237-240.  https://doi.org/10.1016/0165-1218(81)90242-1
  22. Suryanarayana A, Rita P, Reddy PP. Cytogenetic effects of trifluoperazine in mice. Food Chem Toxicol. 1987;25(8):615-617.  https://doi.org/10.1016/0278-6915(87)90023-8
  23. Gasiorowski K, Malinka W, Swiatek P, Jaszczyszyn A. Antimutagenic activity of new analogues of fluphenazine. Cell Mol Biol Lett. 2003;8(4):927-942. 
  24. Gasiorowski K, Brokos B, Kulma A, Ogorzałek A, Skórkowska K. Impact of four antimutagens on apoptosis in genotoxically damaged lymphocytes in vitro. Cell Mol Biol Lett. 2001;6(3):649-675. 
  25. Shoyab M. Enhancement by fluphenazine of dimethylbenz[a]-anthracene-induced mammary tumorigenesis in rats. Cancer Lett. 1983;18(3):297-303.  https://doi.org/10.1016/0304-3835(83)90239-2
  26. Ahuja YR, Jaju M, Saxena R. Cytogenetic effects of psychotropic drug haloperidol on human lymphocytes. Arzneimittelforschung. 1984;34(6):699-701. 
  27. Kitchin RM, Walton CS, Martino RM, Curry PT. In vivo induction of sister chromatid exchange by clinical doses of haloperidol in Swiss albino mice. Environ Mol Mutagen. 1987;10(4):433-436.  https://doi.org/10.1002/em.2850100412
  28. Smith M, de Souza MA, Pugliese S, Mari Jde J. In vivo study of the mutagenicity of biperidine, pipotiazine, chlorpromazine, and haloperidol. Am J Med Genet. 1996;67(2):238.  https://doi.org/10.1002/ajmg.1320670206
  29. Gajski G, Gerić M, Garaj-Vrhovac V. Evaluation of the in vitro cytogenotoxicity profile of antipsychotic drug haloperidol using human peripheral blood lymphocytes. Environ Toxicol Pharmacol. 2014;38(1):316-324.  https://doi.org/10.1016/j.etap.2014.06.011
  30. Asanami S, Shimono K. Species-level differences between mice and rats in regards to micronucleus induction with the hypothermia-inducing drug haloperidol. Mutat Res. 2009;676(1-2):102-105.  https://doi.org/10.1016/j.mrgentox.2009.04.011
  31. CPMP opinion following an article 36 referral Sertindole. Accessed May 29, 2022. https://www.ema.europa.eu/en/documents/referral/opinion-following-article-36-referral-sertindole-international-non-proprietary-name-inn-sertindole_en.pdf
  32. Pharmacology review(s). Application number 200603. Accessed May 29, 2022. https://www.accessdata.fda.gov/drugsatfda_docs/nda/2010/200603Orig1s000PharmR.pdf
  33. Kefelioğlu H, Atlı Şekeroğlu Z, Coşguner G, et al. Ziprasidone induces cytotoxicity and genotoxicity in human peripheral lymphocytes. Drug Chem Toxicol. 2017;40(4):425-431.  https://doi.org/10.1080/01480545.2016.1252920
  34. Togar B, Turkez H, Tatar A, et al. The genotoxic potentials of some atypical antipsychotic drugs on human lymphocytes. Toxicol Ind Health. 2012;28(4):327-333.  https://doi.org/10.1177/0748233711410919
  35. Asghari M, Shaghaghi Z, Farzipour S, et al. Radioprotective effect of olanzapine as an anti-psychotic drug against genotoxicity and apoptosis induced by ionizing radiation on human lymphocytes. Mol Biol Rep. 2019;46(6):5909-5917. https://doi.org/10.1007/s11033-019-05024-x
  36. Shokrzadeh M, Mohammadpour A, Modanloo M, et al. Cytotoxic effects of aripiprazole on mkn45 and nih3t3 cell lines and genotoxic effects on human peripheral blood lymphocytes. Arq Gastroenterol. 2019;56(2):155-159.  https://doi.org/10.1590/S0004-2803.201900000-31
  37. Picada JN, Dos Santos Bde J, Celso F, et al. Neurobehavioral and genotoxic parameters of antipsychotic agent aripiprazole in mice. Acta Pharmacol Sin. 2011;32(10):1225-1232. https://doi.org/10.1038/aps.2011.77
  38. Pastor N, Kaplan C, Domínguez I, et al. Cytotoxicity and mitotic alterations induced by non-genotoxic lithium salts in CHO cells in vitro. Toxicol In vitro. 2009;23(3):432-438.  https://doi.org/10.1016/j.tiv.2009.01.009
  39. Slamenová D, Budayová E, Gábelová A, et al. Results of genotoxicity testing of mazindol (degonan), lithium carbonicum (contemnol) and dropropizine (ditustat) in Chinese hamster V79 and human EUE cells. Mutat Res. 1986;169(3):171-177.  https://doi.org/10.1016/0165-1218(86)90096-0
  40. Invega, INN-paliperidone. Accessed May 29, 2022. https://www.ema.europa.eu/en/documents/scientific-discussion/invega-epar-scientific-discussion_en.pdf
  41. Pharmacology review(s). Application number 22-264. Accessed May 29, 2022. https://www.accessdata.fda.gov/drugsatfda_docs/nda/2009/022264s000pharmr.pdf
  42. Reagila, INN-cariprazine. Accessed May 29, 2022. https://www.ema.europa.eu/en/documents/assessment-report/reagila-epar-public-assessment-report_en.pdf
  43. VRAYLARTM (cariprazine) capsules. Accessed May 29, 2022. https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/204370lbl.pdf
  44. Seredenin SB, Avrutskii GYA, Fatkhulin IA, et al. Study of chromosome aberrations in the lymphocytes of patients treated with phenazepam and sydnocarb. Khim.-Farm. Zh. 1980;14:14-18. 
  45. Seredenin SB, Durnev AD. Izuchenie mutagennosti fenazepama i sidnokarba. Khimiko-farmatsevticheskii zhurnal. 1985;19(4):395-399. (In Russ.).
  46. Durnev AD. Kompleksnoe issledovanie mutagennyh svojstv novyh lekarstvennyh preparatov pri razdel’nom i sovmestnom primenenii. Avtoref. kand. med. nauk. M.; 1982:22. 
  47. Igarashi M, Setoguchi M, Takada S, et al. Optimum conditions for detecting hepatic micronuclei caused by numerical chromosome aberration inducers in mice. Mutat Res. 2007;632(1-2):89-98.  https://doi.org/10.1016/j.mrgentox.2007.04.012
  48. Leal Garza CH, Valenciano Cedillo GG, Rojas Alvarado MA, et al. Mutagenic activity of diazepam evaluated by in vivo cytogenetic tests. Arch Med Res. 1998;29(4):285-289. 
  49. Schuler M, Gudi R, Cheung J, et al. Evaluation of phenolphthalein, diazepam and quinacrine dihydrochloride in the in vitro mammalian cell micronucleus test in Chinese hamster ovary (CHO) and TK6 cells. Mutat Res. 2010;702(2):219-229.  https://doi.org/10.1016/j.mrgentox.2010.04.004
  50. Azab M, Khabour OF, Alzoubi KH, et al. Diazepam induced oxidative DNA damage in cultured human lymphocytes. Journal of King Saud University — Science. 2018;30(3):412-416.  https://doi.org/10.1016/j.jksus.2017.03.002
  51. Ibrulj S, Duricić E. Genotoxicity of oxazepam--the micronucleus cytochalasin-B test. Med Arh. 2002;56(2):61-64. 
  52. Al-Terehi MN, Al-Saadi MAK, Mugheer AH, et al. Genotoxic effects of alprazolam in white albino rats. Int Jour Biotechn Allied Fields. 2013;1(6):345-354. 
  53. Chłopkiewicz B, Ejchart A, Anuszewska E. Tofisopam — evaluation of mutagenic and genotoxic properties. Acta Pol Pharm. 2001;58(1):31-34. 
  54. Rothfuss A, O’Donovan M, De Boeck M, et al. Collaborative study on fifteen compounds in the rat-liver Comet assay integrated into 2- and 4-week repeat-dose studies. Mutat Res. 2010;702(1):40-69.  https://doi.org/10.1016/j.mrgentox.2010.07.006
  55. Brambilla G, Martelli A. Update on genotoxicity and carcinogenicity testing of 472 marketed pharmaceuticals. Mutat Res. 2009;681(2-3):209-229.  https://doi.org/10.1016/j.mrrev.2008.09.002
  56. Giri AK, Banerjee S. Genetic toxicology of four commonly used benzodiazepines: a review. Mutat Res. 1996;340(2-3):93-108.  https://doi.org/10.1016/s0165-1110(96)90042-1
  57. Carlo P, Finollo R, Ledda A, et al. Absence of liver DNA fragmentation in rats treated with high oral doses of 32 benzodiazepine drugs. Fundam Appl Toxicol. 1989;12(1):34-41.  https://doi.org/10.1016/0272-0590(89)90059-6
  58. Susheela M, Rao MS. Genotoxicity of chlordiazepoxide hydrochloride on the bone-marrow cells of Swiss mice. Toxicol Lett. 1983;18(1-2):45-48.  https://doi.org/10.1016/0378-4274(83)90069-3
  59. Stopper H, Körber C, Spencer DL, Kirchner S, Caspary WJ, Schiffmann D. An investigation of micronucleus and mutation induction by oxazepam in mammalian cells. Mutagenesis. 1993 Sep;8(5):449-455.  https://doi.org/10.1093/mutage/8.5.449
  60. Lafi A, Parry JM. A study of the induction of aneuploidy and chromosome aberrations after diazepam, medazepam, midazolam and bromazepam treatment. Mutagenesis. 1988;3(1):23-27.  https://doi.org/10.1093/mutage/3.1.23
  61. BuSpar® (buspirone HCl, USP). Accessed May 29, 2022. https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/018731s051lbl.pdf
  62. Zhanataev AK, Lisitsyna TA, Durnev AD, et al. Vliyanie afobazola na DNk povrezhdeniya u bol’nykh sistemnoi krasnoi volchankoi. Byulleten’ eksperimental’noi biologii i meditsiny. 2009;148(10):404-407. (In Russ.).
  63. Zabrodina VV, Shreder ED, Shreder OV, et al. Effect of Afobazole and Betaine on DNA Damage in Placental and Embryonic Tissues of Rats with Experimental Streptozocin Diabetes. Bull Exp Biol Med. 2015;159(6):757-760.  https://doi.org/10.1007/s10517-015-3068-5
  64. Shreder ED, Shreder OV, Zabrodina VV, et al. Afobazole modifies the neurotoxic and genotoxic effects in rat prenatal alcoholization model. Bull Exp Biol Med. 2014;157(4):492-495.  https://doi.org/10.1007/s10517-014-2599-5
  65. Durnev AD, Zhanataev AK, Eremina NV. Geneticheskaya toksikologiya. M.: Tipografiya Mittel’ Press; 2022;286. (In Russ.).
  66. Almeida IV, Domingues G, Soares LC, et al. Evaluation of cytotoxicity and mutagenicity of the benzodiazepine flunitrazepam in vitro and in vivo. Brazilian Journal of Pharmaceutical Sciences. 2014;50(2):251-256.  https://doi.org/10.1590/S1984-82502014000200003
  67. Imovane. Product Monograph. Accessed May 29, 2022. https://products.sanofi.ca/en/imovane.pdf
  68. TovaltTM ODT (zolpidem tartrate). Accessed May 29, 2022. https://www.accessdata.fda.gov/drugsatfda_docs/label/2007/021412lbl.pdf
  69. Stilnox CR (zolpidem tartrate). Australian Product information. Accessed May 29, 2022. https://apps.medicines.org.au/files/swpsticr.pdf
  70. Zerene, INN-Zaleplon. Accessed May 29, 2022. https://www.ema.europa.eu/en/documents/scientific-discussion/zerene-epar-scientific-discussion_en.pdf
  71. Precedex (dexmedetomidine hydrochloride) injection label. Accessed May 29, 2022. https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/021038s021lbl.pdf
  72. Sileo, dexmedetomidine hyrdochloride. Accessed May 29, 2022. https://www.ema.europa.eu/en/documents/assessment-report/sileo-epar-public-assessment-report_en.pdf
  73. Belsombra (suvorexant) tablets. Accessed May 29, 2022. https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/204569s006lbl.pdf
  74. Madrigal-Bujaidar E, Madrigal-Santillán EO, Alvarez-Gonzalez I, et al. Micronuclei induced by imipramine and desipramine in mice: a subchronic study. Basic Clin Pharmacol Toxicol. 2008;103(6):569-573.  https://doi.org/10.1111/j.1742-7843.2008.00328.x
  75. Saxena R, Ahuja YR. Genotoxicity evaluation of the tricyclic antidepressants amitriptyline and imipramine using human lymphocyte cultures. Environ Mol Mutagen. 1988;12(4):421-430.  https://doi.org/10.1002/em.2860120410
  76. Madrigal-Bujaidar E, Cárdenas García Y, et al. Chromosomal aberrations induced by imipramine and desipramine in mouse. Hum Exp Toxicol. 2010;29(4):297-302.  https://doi.org/10.1177/0960327110361751
  77. Solek P, Koszla O, Mytych J, et al. Neuronal life or death linked to depression treatment: the interplay between drugs and their stress-related outcomes relate to single or combined drug therapies. Apoptosis. 2019;24(9-10):773-784.  https://doi.org/10.1007/s10495-019-01557-5
  78. El-Fikya SA, Abou-ZaidbIbrahim FA, AlyFahmyc MFM, et al. Genotoxic effect of the tricyclic antidepressant drug clomipramine hydrochloride in somatic and germ cells of male mice. Asian Pacific Journal of Tropical Disease. 2016;6(4):321-327.  https://doi.org/10.1016/S2222-1808(15)61038-6
  79. Hassanane MS, Hafiz N, Radwan W, et al. Genotoxic evaluation for the tricyclic antidepressant drug, amitriptyline. Drug Chem Toxicol. 2012;35(4):450-455.  https://doi.org/10.3109/01480545.2011.642382
  80. Düsman E, Almeida IV, Mariucci RG, et al. Cytotoxicity and mutagenicity of fluoxetine hydrochloride (Prozac), with or without vitamins A and C, in plant and animal model systems. Genet Mol Res. 2014;13(1):578-589.  https://doi.org/10.4238/2014.January.28.3
  81. Elmorsy E, Al-Ghafari A, Almutairi FM, et al. Antidepressants are cytotoxic to rat primary blood brain barrier endothelial cells at high therapeutic concentrations. Toxicol In vitro. 2017;44:154-163.  https://doi.org/10.1016/j.tiv.2017.07.011
  82. Celexa Label. Accessed May 29, 2022. https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/020822s047lbl.pdf
  83. Attia SM, Bakheet SA. Citalopram at the recommended human doses after long-term treatment is genotoxic for male germ cell. Food Chem Toxicol. 2013;53:281-285.  https://doi.org/10.1016/j.fct.2012.11.051
  84. Battal D, Aktas A, Sungur MA, et al. In vivo genotoxicity assessment of sertraline by using alkaline comet assay and the cytokinesis-block micronucleus assay. Basic Clin Pharmacol Toxicol. 2013;113(5):339-346.  https://doi.org/10.1111/bcpt.12095
  85. Istifli ES, Çelik R, Hüsunet MT, et al. In vitro cytogenotoxic evaluation of sertraline. Interdiscip Toxicol. 2018;11(3):181-188.  https://doi.org/10.2478/intox-2018-0015
  86. Label for Fluvoxamine maleate. Accessed May 29, 2022. https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/021519s009lbl.pdf
  87. Cobanoglu H, Coskun M, Çayir A, et al. In vitro genotoxic and cytotoxic effects of doxepin and escitalopram on human peripheral lymphocytes. Drug Chem Toxicol. 2018;41(2):238-244.  https://doi.org/10.1080/01480545.2017.1365885.
  88. Avuloglu Yilmaz E, Unal F, Yuzbasioglu D. Evaluation of cytogenetic and DNA damage induced by the antidepressant drug-active ingredients, trazodone and milnacipran, in vitro. Drug Chem Toxicol. 2017;40(1):57-66.  https://doi.org/10.1080/01480545.2016.1174870
  89. Norizadeh Tazehkand M, Topaktas M. The in vitro genotoxic and cytotoxic effects of remeron on human peripheral blood lymphocytes. Drug Chem Toxicol. 2015;38(3):266-271.  https://doi.org/10.3109/01480545.2014.947425
  90. Ayabaktı S, Yavuz Kocaman A. Cytogenotoxic effects of venlafaxine hydrochloride on cultured human peripheral blood lymphocytes. Drug Chem Toxicol. 2020;43(2):192-199.  https://doi.org/10.1080/01480545.2018.1486410
  91. Hassani M, Ghassemi-Barghi N, Modanloo M, et al. Cytotoxic effects of duloxetine on MKN45 and NIH3T3 cell lines and genotoxic effects on human peripheral blood lymphocytes. Arq Gastroenterol. 2019;56(4):372-376.  https://doi.org/10.1590/S0004-2803.201900000-71
  92. Madrigal-Bujaidar E, Álvarez-González I, Madrigal-Santillán EO, et al. Evaluation of Duloxetine as Micronuclei Inducer in an Acute and a Subchronic Assay in Mouse. Biol Pharm Bull. 2015;38(8):1245-1249. https://doi.org/10.1248/bpb.b15-00152
  93. Pereira P, Gianesini J, da Silva Barbosa C, et al. Neurobehavioral and genotoxic parameters of duloxetine in mice using the inhibitory avoidance task and comet assay as experimental models. Pharmacol Res. 2009;59(1):57-61.  https://doi.org/10.1016/j.phrs.2008.09.014
  94. Bruhwyler J, Liégeois JF, Géczy J. Pirlindole: a selective reversible inhibitor of monoamine oxidase A. A review of its preclinical properties. Pharmacol Res. 1997;36(1):23-33.  https://doi.org/10.1006/phrs.1997.0196
  95. Valdoxan, INN-agomelatine. Accessed May 29, 2022. https://www.ema.europa.eu/en/documents/product-information/valdoxan-epar-product-information_en.pdf
  96. Trintellix (vortioxetine) label. Accessed May 29, 2022. https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/204447s013lbl.pdf
  97. Sovrima, INN-idebenone. Accessed May 29, 2022. https://www.ema.europa.eu/en/documents/assessment-report/sovrima-epar-public-assessment-report_en.pdf
  98. Galal AF, Lamiaa MS, Mahrousa MH, Somaia AN, Omar ME. Citicoline Ameliorates Neuro- and Genotoxicity Induced by Acute Malathion Intoxication in Rats. Journal of Bioscience and Applied Research. 2019;5(2):246-261.  https://doi.org/10.21608/jbaar.2019.146800
  99. Shiwaku H, Okazawa H. Impaired DNA damage repair as a common feature of neurodegenerative diseases and psychiatric disorders. Curr Mol Med. 2015;15(2):119-128.  https://doi.org/10.2174/1566524015666150303002556
  100. Czarny P, Kwiatkowski D, Toma M, et al. Impact of Single Nucleotide Polymorphisms of Base Excision Repair Genes on DNA Damage and Efficiency of DNA Repair in Recurrent Depression Disorder. Mol Neurobiol. 2017;54(6):4150-4159. https://doi.org/10.1007/s12035-016-9971-6
  101. Zhang P, Dilley C, Mattson MP. DNA damage responses in neural cells: Focus on the telomere. Neuroscience. 2007;145(4):1439-1448. https://doi.org/10.1016/j.neuroscience.2006.11.052
  102. Subba Rao K. Mechanisms of disease: DNA repair defects and neurological disease. Nat Clin Pract Neurol. 2007;3(3):162-172.  https://doi.org/10.1038/ncpneuro0448
  103. Raza MU, Tufan T, Wang Y, et al. DNA Damage in Major Psychiatric Diseases. Neurotox Res. 2016;30(2):251-267.  https://doi.org/10.1007/s12640-016-9621-9
  104. Bonassi S, El-Zein R, Bolognesi C, et al. Micronuclei frequency in peripheral blood lymphocytes and cancer risk: evidence from human studies. Mutagenesis. 2011;26(1):93-100.  https://doi.org/10.1093/mutage/geq075
  105. Fenech M, Holland N, Zeiger E, et al. The HUMN and HUMNxL international collaboration projects on human micronucleus assays in lymphocytes and buccal cells-past, present and future. Mutagenesis. 2011;26(1):239-245.  https://doi.org/10.1093/mutage/geq051
  106. Collins AR. The comet assay for DNA damage and repair: principles, applications, and limitations. Mol Biotechnol. 2004;26(3):249-261.  https://doi.org/10.1385/MB:26:3:249
  107. Muraleedharan A, Menon V, Rajkumar RP, et al. Assessment of DNA damage and repair efficiency in drug naïve schizophrenia using comet assay. J Psychiatr Res. 2015;68:47-53.  https://doi.org/10.1016/j.jpsychires.2015.05.018
  108. Topak OZ, Ozdel O, Dodurga Y, Secme M. An evaluation of the differences in DNA damage in lymphocytes and repair efficiencies in patients with schizophrenia and schizoaffective disorder. Schizophr Res. 2018;202:99-105.  https://doi.org/10.1016/j.schres.2018.06.052
  109. Psimadas D, Messini-Nikolaki N, Zafiropoulou M, et al. DNA damage and repair efficiency in lymphocytes from schizophrenic patients. Cancer Lett. 2004;204(1):33-40.  https://doi.org/10.1016/j.canlet.2003.09.022
  110. Kalaev VN, Skamrova GB, Ignatova IV. Otsenka stabil’nosti geneticheskogo materiala muzhchin, bol’nykh paranoidnoi shizofreniei, na raznykh stadiyakh lecheniya s ispol’zovaniem mikroyadernogo testa v bukkal’nom epitelii. Ekologicheskaya genetika. 2015;13(3):3-14. (In Russ.).
  111. Kalaev VN, Nikitina OG, Nikitina TYu, et al. Mikroyadernyi test v bukkal’nom epitelii bol’nykh shizofreniei na raznykh stadiyakh lecheniya zabolevaniya. Sistemnyi analiz i upravlenie v biomeditsinskikh sistemakh. 2010;9(4):817-821. (In Russ.).
  112. Andreazza AC, Frey BN, Erdtmann B, et al. DNA damage in bipolar disorder. Psychiatry Res. 2007;153(1):27-32.  https://doi.org/10.1016/j.psychres.2006.03.025
  113. Frey BN, Andreazza AC, Kunz M, et al. Increased oxidative stress and DNA damage in bipolar disorder: a twin-case report. Prog Neuropsychopharmacol Biol Psychiatry. 2007;31(1):283-285.  https://doi.org/10.1016/j.pnpbp.2006.06.011
  114. Czarny P, Kwiatkowski D, Kacperska D, et al. Elevated level of DNA damage and impaired repair of oxidative DNA damage in patients with recurrent depressive disorder. Med Sci Monit. 2015;21:412-418.  https://doi.org/10.12659/MSM.892317
  115. Rybka J, Kędziora-Kornatowska K, Banaś-Leżańska P, et al. Interplay between the pro-oxidant and antioxidant systems and proinflammatory cytokine levels, in relation to iron metabolism and the erythron in depression [published correction appears in Free Radic Biol Med. 2014 Apr;69:197]. Free Radic Biol Med. 2013;63:187-194.  https://doi.org/10.1016/j.freeradbiomed.2013.05.019
  116. Ahmadimanesh M, Abbaszadegan MR, Morshedi Rad D, et al. Effects of selective serotonin reuptake inhibitors on DNA damage in patients with depression. J Psychopharmacol. 2019;33(11):1364-1376. https://doi.org/10.1177/0269881119874461
  117. Ng F, Berk M, Dean O, et al. Oxidative stress in psychiatric disorders: evidence base and therapeutic implications. Int J Neuropsychopharmacol. 2008;11(6):851-876.  https://doi.org/10.1017/S1461145707008401
  118. Bozkurt G, Abay E, Ates I, et al. Clastogenicity of selective serotonin-reuptake inhibitors. Mutat Res. 2004;558(1-2):137-144.  https://doi.org/10.1016/j.mrgentox.2003.11.005
  119. American Psychiatric Association. Diagnostic and statistical manual of mental disorders: DSM-IV. 4th ed. Washington (DC): American Psychiatric Association. 1994;866. 
  120. Torres-Bugarín O, Pacheco-Gutiérrez AG, Vázquez-Valls E, et al. Micronuclei and nuclear abnormalities in buccal mucosa cells in patients with anorexia and bulimia nervosa. Mutagenesis. 2014;29(6):427-431.  https://doi.org/10.1093/mutage/geu044
  121. Andrianopoulos C, Stephanou G, Demopoulos NA. Genotoxicity of hydrochlorothiazide in cultured human lymphocytes. I. Evaluation of chromosome delay and chromosome breakage. Environ Mol Mutagen. 2006;47(3):169-178.  https://doi.org/10.1002/em.20180
  122. Mondal SC, Tripathi DN, Vikram A, Ramarao P, Jena GB. Furosemide-induced genotoxicity and cytotoxicity in the hepatocytes, but weak genotoxicity in the bone marrow cells of mice. Fundam Clin Pharmacol. 2012;26(3):383-392.  https://doi.org/10.1111/j.1472-8206.2011.00927.x
  123. Snyder RD, Green JW. A review of the genotoxicity of marketed pharmaceuticals. Mutat Res. 2001;488(2):151-169.  https://doi.org/10.1016/s1383-5742(01)00055-2
  124. Stoll RE, Blanchard KT, Stoltz JH, et al. Phenolphthalein and bisacodyl: assessment of genotoxic and carcinogenic responses in heterozygous p53 (+/-) mice and syrian hamster embryo (SHE) assay. Toxicol Sci. 2006;90(2):440-450.  https://doi.org/10.1093/toxsci/kfj081
  125. Tsutsui T, Tamura Y, Yagi E, et al. Cell-transforming activity and genotoxicity of phenolphthalein in cultured Syrian hamster embryo cells. Int J Cancer. 1997;73(5):697-701. https://doi.org/10.1002/(sici)1097-0215(19971127)73:5<697::aid-ijc14>3.0.co;2-3 "> 3.0.co;2-3" target="_blank">https://doi.org/10.1002/(sici)1097-0215(19971127)73:5<697::aid-ijc14>3.0.co;2-3
  126. Bigatti MP, Corona D, Munizza C. Increased sister chromatid exchange and chromosomal aberration frequencies in psychiatric patients receiving psychopharmacological therapy. Mutat Res. 1998;413(2):169-175.  https://doi.org/10.1016/s1383-5718(98)00028-x
  127. Zhanataev AK, Durnev AD, Seredenin SB. Sravnitel’noe izuchenie antimutagennoi aktivnosti afobazola pri razlichnykh rezhimakh primeneniya. Byulleten’ eksperimental’noi biologii i meditsiny. 2000;130(11):539-542. (In Russ.).
  128. Shreder OV, Shreder ED, Durnev AD, et al. Sopryazhennost’ genotoksikikh i teratogennykh effektov, vyzyvaemykh tsiklofosfamidom, i ikh modifikatsiya afobazolom. Gigiena i sanitariya. 2011;5:64-68. (In Russ.).
  129. Neznamov GG, Syunyakov TS, Zolotov NN, et al. Terapevticheskoe vliyanie anksiolitikov fenazepama i afobazola na soderzhanie malonovogo al’degida v plazme krovi i psikhicheskoe sostoyanie bol’nykh s trevozhnymi rasstroistvami. Psikhicheskie rasstroistva v obshchei meditsine. 2014;2:40-47. (In Russ.).
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