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Baymeeva N.V.

Mental Health Research Center, Moscow

Miroshnichenko I.I.

Mental Health Research Center

Platova A.I.

Mental Health Reseroch center

Tikhonov D.V.

Mental Health Research Center

Kaleda V.G.

Mental Health Research Centre

Therapeutic drug monitoring of aripiprazole as part of the individualization of the pharmacotherapy of schizophrenia

Authors:

Baymeeva N.V., Miroshnichenko I.I., Platova A.I., Tikhonov D.V., Kaleda V.G.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2022;122(1): 98‑103

DOI: 10.17116/jnevro202212201198

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Table of contents

THERAPEUTIC DRUG MONITORING OF ARIPIPRAZOLE AS PART OF THE INDIVIDUALIZATION OF THE PHARMACOTHERAPY OF SCHIZOPHRENIA
THERAPEUTIC DRUG MONITORING OF ARIPIPRAZOLE AS PART OF THE INDIVIDUALIZATION OF THE PHARMACOTHERAPY OF SCHIZOPHRENIA

To cite this article:

Baymeeva NV, Miroshnichenko II, Platova AI, Tikhonov DV, Kaleda VG. Therapeutic drug monitoring of aripiprazole as part of the individualization of the pharmacotherapy of schizophrenia. S.S. Korsakov Journal of Neurology and Psychiatry. 2022;122(1):98‑103. (In Russ.)
https://doi.org/10.17116/jnevro202212201198

Подписка 2025-2 (S.S. Korsakov Journal of Neurology and Psychiatry)
 
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OBJECTIVE

To personalize pharmacotherapy with aripiprazole in patients with schizophrenia via therapeutic drug monitoring (TDM).

MATERIAL AND METHODS

TDM of aripiprazole (ARI) and its active metabolite dehydroaripiprazole (DHA) was performed for patients diagnosed with schizophrenia (ICD-10 F20.00; F20.01; F20.02). Thirty-six parameters were assessed. To carry out TDM, the method of high-performance liquid chromatography with mass spectrometry was chosen employing a validated method.

RESULTS

TLM was performed in a group of young patients: 26.5±10.1 years old, average weight 77.2±16.2 kg, average PANSS score 81.4±21.4, UKU score 14.5±3.9. An average ARI concentration was 18.4±7.9 mg, serum ARI concentration 417.9±362.4 ng/ml, serum DHA concentration 117.5±116.1 ng/ml and the total concentration 535.4±478.5 ng/ml. Equations of correlation dependences of concentration on dose are obtained for ARI and DHA.

CONCLUSION

The results show the significant metabolism of ARI. A combined determination of the main substance and its active metabolite DHA in the patient’s blood serum is advisable for correct assessment of the TLM result in patients with mental diseases.

Keywords:

aripiprazole
dehydroaripiprazole
therapeutic drug monitoring
high performance liquid chromatography with mass spectrometry

Authors:

Baymeeva N.V.

Mental Health Research Center, Moscow

Miroshnichenko I.I.

Mental Health Research Center

Platova A.I.

Mental Health Reseroch center

Tikhonov D.V.

Mental Health Research Center

Kaleda V.G.

Mental Health Research Centre

Received:

19.11.2020

Accepted:

25.03.2021

List of references:

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