The link of platelet cytochrome C-oxidase activity with some clinical parameters of depression in elderly patients

Prokhorova T.A.; Savushkina O.K.; Boksha I.S.; Tereshkina E.B.; Safarova T.P.; Yakovleva O.B.; Kornilov V.V.; Shipilova E.S.; Vorobyeva E.A.; Burbaeva G.Sh.

doi:https://doi.org/10.17116/jnevro202112103186

Prokhorova T.A.

Mental Health Research Centre

Savushkina O.K.

Mental Health Research Centre

Boksha I.S.

Mental Health Research Centre;
Gamaleya National Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation

Tereshkina E.B.

Mental Health Research Centre

Safarova T.P.

Mental Health Research Centre

ORCID: 0000-0002-3509-1622

Yakovleva O.B.

Mental Health Research Centre

ORCID: 0000-0002-2653-0427

Kornilov V.V.

Mental Health Research Centre

Shipilova E.S.

Mental Health Research Centre

Vorobyeva E.A.

Mental Health Research Centre

Burbaeva G.Sh.

Mental Health Research Centre

The link of platelet cytochrome C-oxidase activity with some clinical parameters of depression in elderly patients

Authors:

Prokhorova T.A., Savushkina O.K., Boksha I.S., Tereshkina E.B., Safarova T.P., Yakovleva O.B., Kornilov V.V., Shipilova E.S., Vorobyeva E.A., Burbaeva G.Sh.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2021;121(3): 86‑92

DOI: 10.17116/jnevro202112103186

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To cite this article:

Prokhorova TA, Savushkina OK, Boksha IS, et al. . The link of platelet cytochrome C-oxidase activity with some clinical parameters of depression in elderly patients. S.S. Korsakov Journal of Neurology and Psychiatry. 2021;121(3):86‑92. (In Russ.)
https://doi.org/10.17116/jnevro202112103186

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)

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Abstract:

OBJECTIVE

To search for correlations between platelet cytochrome c-oxidase (COX) activity and the quality of therapeutic outcomes and other clinical parameters of depression in elderly patients.

MATERIAL AND METHODS

Twenty elderly women, aged 55—78 years, with depressive episodes in recurrent depressive disorder (RDD) or bipolar affective disorder (BD) were studied. COX activity and severity of depression were evaluated twice: before the beginning of antidepressant treatment and at the 28-th day of the therapy, using the Hamilton Depression Rating Scale (HAMD-17) and the Hamilton Anxiety Rating Scale (HAM-A).

RESULTS

Significant correlations were revealed between platelet COX activity and some clinical parameters of the disease and the severity of depression in patients after treatment. The baseline level of the platelet COX activity was correlated with the age of disease onset (R= –0.63, p=0.003) and its duration (R=0.55, p=0.010). Significant negative correlations were also found between the baseline level of COX activity and depression severity (HAMD-17 total score) (R= –0.48, p=0.032) and the severity of anxiety (HARSHAM-A total score) (R= –0.54, p=0.010) after 28-day treatment.

CONCLUSION

This pilot study has revealed a link between platelet COX activity and the severity of depression and anxiety after a 28-day antidepressant therapy. The results indicate the prospects for further study of COX as a biomarker of therapeutic outcomes in elderly patients with depression.

Keywords:

elderly depression

platelet cytochrome c oxidase

depression treatment outcomes

Authors:

Prokhorova T.A.

Mental Health Research Centre

Savushkina O.K.

Mental Health Research Centre

Boksha I.S.

Mental Health Research Centre;
Gamaleya National Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation

Tereshkina E.B.

Mental Health Research Centre

Safarova T.P.

Mental Health Research Centre

ORCID: 0000-0002-3509-1622

Yakovleva O.B.

Mental Health Research Centre

ORCID: 0000-0002-2653-0427

Kornilov V.V.

Mental Health Research Centre

Shipilova E.S.

Mental Health Research Centre

Vorobyeva E.A.

Mental Health Research Centre

Burbaeva G.Sh.

Mental Health Research Centre

Received:

07.05.2020

Accepted:

06.07.2020

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References:

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