Specific features of immunological reactions in elderly and young patients with exacerbation of schizophrenia

Klyushnik T.P.; Barkhatova A.N.; Sheshenin V.S.; Androsova L.V.; Zozulya S.A.; Otman I.N.; Pochueva V.V.

doi:https://doi.org/10.17116/jnevro202112102153

Klyushnik T.P.

Mental Health Research Center

ORCID: 0000-0001-5148-3864

Barkhatova A.N.

Mental Health Research Center

Sheshenin V.S.

Mental Health Research Center

Androsova L.V.

Mental Health Research Center

Zozulya S.A.

Mental Health Research Center

ORCID: 0000-0001-5390-6007

Otman I.N.

Mental Health Research Centre

Pochueva V.V.

Mental Health Research Center

Specific features of immunological reactions in elderly and young patients with exacerbation of schizophrenia

Authors:

Klyushnik T.P., Barkhatova A.N., Sheshenin V.S., Androsova L.V., Zozulya S.A., Otman I.N., Pochueva V.V.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2021;121(2): 53‑59

DOI: 10.17116/jnevro202112102153

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To cite this article:

Klyushnik TP, Barkhatova AN, Sheshenin VS, Androsova LV, Zozulya SA, Otman IN, Pochueva VV. Specific features of immunological reactions in elderly and young patients with exacerbation of schizophrenia. S.S. Korsakov Journal of Neurology and Psychiatry. 2021;121(2):53‑59. (In Russ.)
https://doi.org/10.17116/jnevro202112102153

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)

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OBJECTIVE

To identify levels of inflammation markers (the enzymatic activity of leukocyte elastase (LE), the functional activity of the α1-proteinase inhibitor (α1-PI), autoantibodies to neurotrophin S100b and myelin basic protein (MBP)) in blood plasma of old- and young-aged patients with schizophrenia in comparison with features of the clinical course of schizophrenia.

MATERIAL AND METHODS

Two age groups of patients with schizophrenia were examined. The 1^st group consisted of 19 female patients, aged 60 to 78 years (mean age 67.3±5.4 years), with disease duration from 0.5 months to 29 years (9.7±7.6). The 2^nd group comprised 24 female patients, aged 19 to 42 years (mean age 26.8±6.3 years), with disease duration from 0.15 to 6.6 years (3.3±2.4). Nineteen age-matched healthy women were included in two control groups. Inflammatory and autoimmune markers were measured in blood plasma using «Neuro-immuno-test technology».

RESULTS

In the 1^st group, a relative smoothness and rigidity of the productive symptoms profile, a reduction of disease progression and a tendency to the development of negative symptoms were established. The 2^nd group was characterized by polymorphism, severity and dynamism of productive disorders, as well as the progression and lability of the schizophrenic process. The most significant differences in the spectrum of the analysed immune markers relate to the ratio of the activity of LE and its inhibitor α1-PI, i.e. proteinase-inhibitory index (PII).

CONCLUSIONS

The identified multidirectional changes of PII in elderly patients compared to the controls may reflect the imbalance of the inflammatory response and the role of this imbalance in shaping the characteristics of psychopathological symptoms in these patients.

Keywords:

schizophrenia in young and old aged patients

inflammation markers

leukocyte elastase

α1-proteinase inhibitor activity

autoantibodies to S100b and myelin basic protein

Authors:

Klyushnik T.P.

Mental Health Research Center

ORCID: 0000-0001-5148-3864

Barkhatova A.N.

Mental Health Research Center

Sheshenin V.S.

Mental Health Research Center

Androsova L.V.

Mental Health Research Center

Zozulya S.A.

Mental Health Research Center

ORCID: 0000-0001-5390-6007

Otman I.N.

Mental Health Research Centre

Pochueva V.V.

Mental Health Research Center

Received:

28.05.2020

Accepted:

08.06.2020

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