Drug-induced restless legs syndrome

Ostroumova T.M.; Ostroumova O.D.; Filippova Y.A.; Parfenov V.A.

doi:https://doi.org/10.17116/jnevro2020120041129

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Abstract:

Restless legs syndrome (RLS) is a sensorimotor disorder characterized by complaints of a strong desire to move legs during periods of rest or inactivity, which is relieved by movement (most pronounced in the evening or at night). Multiple studies have reported drug-induced RLS caused by antipsychotics, antidepressants and antiepileptic medications. Risk factors for drug-induced RLS include older age, gastrointestinal diseases, high medication dose, simultaneous use of ≥2 drugs. The mechanism of drug-induced RLS is most often associated with the effect of medications on various receptors and neurotransmitter systems, in particular, the dopamine system. Drug-induced RLS treatment includes identification and withdrawal of a drug that caused RLS or a decrease in its dosage. Prevention of drug-induced RLS is based on compliance with the principles of rational pharmacotherapy.

Keywords:

restless legs syndrome

drug-induced restless legs syndrome

adverse drug reactions

Authors:

Ostroumova T.M.

Sechenov First Moscow State Medical University, Moscow, Russia

SPIN RSCI: 5043-4713
Scopus AuthorID: 57200081144
ORCID: 0000-0003-1499-247X

Ostroumova O.D.

Kafedra fakul'tetskoĭ terapii i professional'nykh bolezneĭ Moskovskogo gosudarstvennogo mediko-stomatologicheskogo universiteta im. A.I. Evdokimova, Moskva

SPIN RSCI: 3910-6585
Scopus AuthorID: 7004067629
ResearcherID: M-9553-2014
ORCID: 0000-0002-0795-8225

Filippova Y.A.

Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia

Parfenov V.A.

Pervyĭ Moskovskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. I.M. Sechenova, Moskva

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