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Kondratieva E.A.

Polenov Neurosurgical Institute branch of Almazov National Medical Research Centre

Kondratev S.A.

Polenov Neurosurgical Institute branch of Almazov National Medical Research Centre

Denisova A.A.

Admiral Makarov State University of Maritime and Inland Shipping

Ivanova N.E.

Polenov Russian Scientific Research Neurosurgical Institute — branch of Almazov National Medical Research Center

Kondratiev A.N.

Polenov Neurosurgical Institute

Results of treatment with intravenous amantadine sulfate (PK-Merz) patients with chronic disorders of consciousness

Authors:

Kondratieva E.A., Kondratev S.A., Denisova A.A., Ivanova N.E., Kondratiev A.N.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2020;120(12): 102‑108

DOI: 10.17116/jnevro2020120121102

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RESULTS OF TREATMENT WITH INTRAVENOUS AMANTADINE SULFATE (PK-MERZ) PATIENTS WITH CHRONIC DISORDERS OF CONSCIOUSNESS
RESULTS OF TREATMENT WITH INTRAVENOUS AMANTADINE SULFATE (PK-MERZ) PATIENTS WITH CHRONIC DISORDERS OF CONSCIOUSNESS

To cite this article:

Kondratieva EA, Kondratev SA, Denisova AA, Ivanova NE, Kondratiev AN. Results of treatment with intravenous amantadine sulfate (PK-Merz) patients with chronic disorders of consciousness. S.S. Korsakov Journal of Neurology and Psychiatry. 2020;120(12):102‑108. (In Russ.)
https://doi.org/10.17116/jnevro2020120121102

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
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Abstract:

The article presents literature review of the recent publications devoted to the drugs with dopaminergic, antiglutamatergic and GABA-ergic effects in the treatment of patients with vegetative state/areactive wakefulness syndrome (VS/AWS). The authors analyzed their own results of the effects of intravenous form of amantadine sulfate (PK Merz) in 142 VS/AWS patients caused by different etiological factors. Depending on the dominant neurological symptoms, patients were divided into three main groups: areactive type of course (group 1 — 61 patients), predominance of primitive limbic reactions (group 2 — 35 patients) and predominance of extrapyramidal symptoms (group 3 — 46 patients). Therapy results were evaluated one month later by CRS-R scale, which showed that the most distinct positive dynamics was observed in group 3.

Keywords:

chronic disorders of consciousness
vegetative state
areactive wakefulness syndrome
minimally consciousness state
dopaminergic drugs
antiglutamatergic drugs
amantadine sulfate

Authors:

Kondratieva E.A.

Polenov Neurosurgical Institute branch of Almazov National Medical Research Centre

Kondratev S.A.

Polenov Neurosurgical Institute branch of Almazov National Medical Research Centre

Denisova A.A.

Admiral Makarov State University of Maritime and Inland Shipping

Ivanova N.E.

Polenov Russian Scientific Research Neurosurgical Institute — branch of Almazov National Medical Research Center

Kondratiev A.N.

Polenov Neurosurgical Institute

Received:

23.10.2020

Accepted:

09.11.2020

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