Analysis of the clinical efficacy of platelet-rich plasma therapy in the treatment of patients with isolated facet-syndrome of the lumbar spine

Byvaltsev V.A.; Kalinin A.A.; Okoneshnikova A.K.; Satardinova E.E.

doi:https://doi.org/10.17116/jnevro201911911127

Byvaltsev V.A.

Irkutsk State Medical University;
Private Healthcare Institution «Clinical Hospital «Russian Railways-Medicine»;
Irkutsk State Medical Academy of Postgraduate Education

Kalinin A.A.

Irkutsk State Medical University;
Private Healthcare Institution «Clinical Hospital «Russian Railways-Medicine»

Okoneshnikova A.K.

Irkutsk State Medical University;
Road Clinical Hospital at st. Irkutsk-Passenger JSC «Russian Railways»

Satardinova E.E.

Irkutsk State Medical Academy of Postgraduate Education

Analysis of the clinical efficacy of platelet-rich plasma therapy in the treatment of patients with isolated facet-syndrome of the lumbar spine

Authors:

Byvaltsev V.A., Kalinin A.A., Okoneshnikova A.K., Satardinova E.E.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2019;119(11): 27‑31

DOI: 10.17116/jnevro201911911127

Read: 7902 times

Download PDF (RU)

Contact the author

Table of contents

To cite this article:

Byvaltsev VA, Kalinin AA, Okoneshnikova AK, Satardinova EE. Analysis of the clinical efficacy of platelet-rich plasma therapy in the treatment of patients with isolated facet-syndrome of the lumbar spine. S.S. Korsakov Journal of Neurology and Psychiatry. 2019;119(11):27‑31. (In Russ.)
https://doi.org/10.17116/jnevro201911911127

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)

Использование инфографики авторами научных работ

Close metadata

OBJECTIVE

To analyze clinical results of the surgical treatment of patients with isolated facet-syndrome of the lumbar spine using platelet-rich plasma (PRP) therapy for arcuate spine joints.

MATERIAL AND METHODS

The study included 49 patients, aged 39.5 (34; 45), who, after provocative tests, were diagnosed with isolated facet syndrome and operated on from 2015 to 2018 using PRP therapy. A visual analogue pain scale (VAS), Oswestry questionnaire (ODI), Macnab subjective satisfaction scale, and the presence of complications were used to evaluate clinical efficacy. Dynamic evaluation was made on average 18 months after surgery.

RESULTS AND CONCLUSION

PRP therapy is a highly effective method for treatment of patients with isolated facet syndrome caused by degenerative diseases of the facet joints. Clinical efficacy is confirmed by the persistent significant reduction of pain symptoms and restoration of functional status in the early and late postoperative periods with low risks of adverse outcomes.

Keywords:

facet joints

lumbar spine

facet syndrome

PRP therapy

Authors:

Byvaltsev V.A.

Irkutsk State Medical University;
Private Healthcare Institution «Clinical Hospital «Russian Railways-Medicine»;
Irkutsk State Medical Academy of Postgraduate Education

Kalinin A.A.

Irkutsk State Medical University;
Private Healthcare Institution «Clinical Hospital «Russian Railways-Medicine»

Okoneshnikova A.K.

Irkutsk State Medical University;
Road Clinical Hospital at st. Irkutsk-Passenger JSC «Russian Railways»

Satardinova E.E.

Irkutsk State Medical Academy of Postgraduate Education

Received:

23.02.2019

Accepted:

04.06.2019

Close metadata

References:

Byvaltsev VA, Kalinin AA, Okoneshnikova AK. Analysis of the clinical efficacy of applying the method of facetoplasty in the treatment of facet-syndrome in the lumbar spine in patients of elderly and old age. Uspekhi Gerontologii. 2017;30(1):84-91. (In Russ.).
Byvaltsev VA, Kalinin AA, Okoneshnikova AK, Pestryakov YuYa. Anatomical and physiological features of the facet joints. The evolution of facet fixation in the treatment of patients with degenerative diseases of the lumbosacral spine. Vestnik travmatologii i ortopedii im. N.N. Priorova. 2017;3:56-62. (In Russ.).
Gorbatenko AI, Kostyanaya NO. The use of platelet-rich autoplasma in the treatment of osteoarthritis of the knee. Vestnik travmatologii i ortopedii im. N.N. Priorova. 2016;2:40-45. (In Russ.).
Medvedev VL, Opol'sky AM, Kogan MI. Prospects for the development of regenerative technologies. Current knowledge of autoplasma enriched with platelets and the possibility of its use in the treatment of urological diseases. Kuban Scientific Medical Herald Kubanskiy Nauchnyy Meditsinskiy Vestnik. 2018;25(3):155-161. (In Russ.).
Marx RE, Carlson ER, Eichstaedt RM, Schimmele SR, Strauss JE, Georgeff KR. Platelet rich plasma: Growth factor enhancementfor bone grafts. Oral Surg. 1998;85(6):638-646.
Whitman DH, Berry RL, Green DM. Platelet gel: an autologus alternative to fibrin glue with applications in oral and maxillofacial surgery. J Oral Maxillofac Surg. 1997;55(11):1294-1299.
Haynesworth SE, Kadiyala S, Liang LN. Platelet rich plasma stimulates stem cell chemotaxis, proliferation and potentiates osteogenic differentiation. The Spine Journal. 2002;2(5):68. https://doi.org/10.1016/s1529-9430(02)00313-3
Rodin IA, Kiselev IG, Vishnivetskaya LP, Rodin MI, Yakovets MG. Stimulation of osteoregeneration using PRP-therapy. Izvestiya Orenburgskogo Gosudarstvennogo Agrarnogo Universiteta. 2018;3(71):186-190. (In Russ.).
Sonis AG, Sefedinova MYu, Bezrukova MA, Marchenko AA, Ladonin SV. The use of platelet-rich autoplasma in the treatment of patients with purulent-inflammatory diseases of soft tissues, bones and joints. Aspirantskiy Vestnik Povolzh’ya. 2016;5-6:162-167. (In Russ.).
Galea V, Khaterchi A, Robert F, Gerotziafas G, Hatmi M, Elalamy I. Heparin-induced multiple electrode aggregometry is a promising and useful functional tool for heparin-induced thrombocytopenia diagnosis: confirmation in a prospective study. Platelets. 2013;24(6):441-447. https://doi.org/10.3109/09537104.2012.724736
Mohammed S, Yu J. Platelet-rich plasma injections: an emerging therapy for chronic discogenic low back pain. J Spine Surg. 2018;4(1):115-122. https://doi.org/10.21037/jss.2018.03.04
Singla V, Batra YK, Bharti N, Goni VG, Marwaha N. Steroid vs. platelet-rich plasma in ultrasound-guided sacroiliac joint injection for chronic low back pain. Pain Pract. 2017;17(6):782-791. https://doi.org/10.1111/papr.12526
Panagos A. Resolution of a greater than 50-year history of severe, chronic low back pain following an ultrasound-guided platelet-rich plasma infiltration of the thoracolumbar fascia. Cureus. 2018;10(10);E3457. https://doi.org/10.7759/cureus.3457
Oh J, Jo D, Kim K, Shim J, Roh M. Facetoplasty using radiofrequency thermocoagulation for facet joint hypertrophy. Pain Physician. 2016;19(4):649-652.
Fujiwara A, Lim TH, An HS, Tanaka N, Jeon CH, Andersson GB, Haughton VM. The effect of disc degeneration and facet joint osteoarthritis on the segmental flexibility of the lumbar spine. Spine (Phila Pa 1976). 2000;25(23): 3036-3044.
Weishaupt D, Zanetti M, Boos N, Hodler J. MR imaging and CT in osteoarthritis of the lumbar facet joints. Skeletal Radiol. 1999;28(4):215-219.
Wu J, Zhou J, Liu C, Zhang J, Xiong W, Lv Y, Liu R, Wang R, Du Z, Zhang G, Liu Q. Prospective study comparing platelet-rich plasma and local anesthetic (LA)/Corticosteroid in intra-articular injection for the treatment of lumbar facet joint syndrome. Pain Pract. 2017;17(7):914-924. https://doi.org/10.1111/papr.12544
Wu J, Du Z, Lv Y, Zhang J, Xiong W, Wang R, Liu R, Zhang G, Liu Q. A new technique for the treatment of lumbar facet joint syndrome using intra-articular injection with autologous platelet rich plasma. Pain Physician. 2016;19(8):617-625.
Kirchner F, Anitua E. Intradiscal and intra-articular facet infiltrations with plasma rich in growth factors reduce pain in patients with chronic low back pain. J Craniovertebr Junction Spine. 2016;7(4):250-256. https://doi.org/10.4103/0974-8237.193260
Sanapati J, Manchikanti L, Atluri S, Jordan S, Albers SL, Pappolla MA, Kaye AD, Candido KD, Pampati V, Hirsch JA. Do regenerative medicine therapies provide long-term relief in chronic low back pain: a systematic review and metaanalysis. Pain Physician. 2018;21(6):515-540.