Cluster analysis of inflammatory markers in disorders of adaptation

Simonov A.N.

Mental Health Research Center, Moscow, Russia

Klyushnik T.P.

Scientific center of mental health, Moscow, Russia

Androsova L.V.

Scientific center of mental health, Moscow, Russia

Nikitina V.B.

Mental Health Research Institute», Tomsk, Russia

Vetlugina T.P.

Cluster analysis of inflammatory markers in disorders of adaptation

Authors:

Simonov A.N., Klyushnik T.P., Androsova L.V., Nikitina V.B., Vetlugina T.P.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2018;118(7): 59‑66

DOI: 10.17116/jnevro20181187159

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Simonov AN, Klyushnik TP, Androsova LV, Nikitina VB, Vetlugina TP. Cluster analysis of inflammatory markers in disorders of adaptation. S.S. Korsakov Journal of Neurology and Psychiatry. 2018;118(7):59‑66. (In Russ.)
https://doi.org/10.17116/jnevro20181187159

Подписка 2025-2 (S.S. Korsakov Journal of Neurology and Psychiatry)

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Objective. To determine immunophenotypes of patients with adaptation disorders using cluster analysis. The level of inflammatory markers such as leukocyte elastase (LE) enzyme activity and functional activity of α1-protease inhibitor (α1-PI) were used as a classifying attribute (characteristic). Material and methods. The results of evaluation of enzymatic activity of LE and functional activity of α1-PI in 40 patients with adaptation disorders (ICD-10 F43.2) were subjected to cluster analysis. The control group included 23 age- and sex-matched healthy controls. Results. Several algorithms of cluster analysis allow to identify three immunophenotypes in the group of patients with adaptation disorders. Immunophenotypes differed significantly by ratios of LE and α1-PI activity, which were mostly driven by different LE activity. Cluster 1 with the relatively low LE activity and high background α1-PI, is of particular interest because it may reflect the disturbed interaction between the various links of immune response. Conclusion. The obtained results of cluster analysis confirm the hypothesis about the existence of three immunophenotypes in the patients with adaptation disorders, which indicates that a phenotypically similar pattern can be determined by different spectra of immune indices.

Keywords:

adaptation disorders

cluster analysis

leukocyte elastase

α1-proteinase inhibitor

Authors:

Simonov A.N.

Mental Health Research Center, Moscow, Russia

Klyushnik T.P.

Scientific center of mental health, Moscow, Russia

Androsova L.V.

Scientific center of mental health, Moscow, Russia

Nikitina V.B.

Mental Health Research Institute», Tomsk, Russia

Vetlugina T.P.

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