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Alfimova M.V.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN

Golimbet V.E.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN, Moskva

Korovaĭtseva G.I.

Nauchnyĭ tsentr psikhicheskogo zdorovia RAMN, Moskva

Lezheĭko T.V.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN, Moskva

Tikhonov D.V.

Mental Health Research Center, Moscow, Russia

Ganisheva T.K.

Berezin N.B.

Alekseev Psychiatric Hospital №1, Moscow, Russia

Snegireva A.A.

GKUZ "Moskovskaia gorodskaia klinicheskaia psikhiatricheskaia bol'nitsa #1 im. N.A. Alekseeva", Moskva

Shemiakina T.K.

A role of interactions between N-methyl-D-aspartate and dopamine receptors in facial emotion recognition impairment in schizophrenia

Authors:

Alfimova M.V., Golimbet V.E., Korovaĭtseva G.I., Lezheĭko T.V., Tikhonov D.V., Ganisheva T.K., Berezin N.B., Snegireva A.A., Shemiakina T.K.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2017;117(6): 47‑52

DOI: 10.17116/jnevro20171176147-52

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Table of contents

A ROLE OF INTERACTIONS BETWEEN N-METHYL-D-ASPARTATE AND DOPAMINE RECEPTORS IN FACIAL EMOTION RECOGNITION IMPAIRMENT IN SCHIZOPHRENIA
A ROLE OF INTERACTIONS BETWEEN N-METHYL-D-ASPARTATE AND DOPAMINE RECEPTORS IN FACIAL EMOTION RECOGNITION IMPAIRMENT IN SCHIZOPHRENIA

To cite this article:

Alfimova MV, Golimbet VE, Korovaĭtseva GI, et al. A role of interactions between N-methyl-D-aspartate and dopamine receptors in facial emotion recognition impairment in schizophrenia. S.S. Korsakov Journal of Neurology and Psychiatry. 2017;117(6):47‑52. (In Russ.)
https://doi.org/10.17116/jnevro20171176147-52

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
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Recommended articles:
The role of the rs1800795 poly­morphism of the inte­rleukin 6 gene in the deve­lopment of cognitive defi­cits asso­ciated with schi­zophrenia. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(10):113-120
Abstract:

Objective. To search for genetic mechanisms of facial emotion recognition (FER) impairment, one of the features of schizophrenia that affects social adaptation of patients. Based on the view implicating the interplay between dopaminergic and glutamatergic systems into the pathogenesis of schizophrenia, authors explored the interaction effects of the C366G polymorphism in the GRIN2B gene encoding NMDA receptor subunit NR2B with ANKK1/DRD2 Taq1A and 48-VNTR DRD4 polymorphisms on FER. Material and methods. GRIN2B -DRD2 interaction effects were studied in a sample of 237 patients and 235 healthy controls, GRIN2B — DRD4 in 268 patients and 208 controls. Results and conclusion. Both effects were significant in combined samples of patients and controls (GRIN2B X DRD2, F=4.12, p=0.043; GRIN2B X DRD4, F=6.43, p=0.012). Further analysis confirmed the interaction effect of GRIN2B and DRD2 polymorphisms on FER in patients with schizophrenia. In patients with a less efficient allele of the DRD2 in the absence of the minor allele of the GRIN2B C366G polymorphism, the results were close to normal values while patients with minor alleles of both polymorphisms showed the worst results. This finding is in line with the conceptions on a possible role of NMDA-receptor hypofunction and D2-mediated regulation of NMDA-receptor activity in FER impairments in schizophrenia.

Keywords:

GRIN2B
DRD2
DRD4
facial emotion recognition
epistatic effects
psychosis

Authors:

Alfimova M.V.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN

Golimbet V.E.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN, Moskva

Korovaĭtseva G.I.

Nauchnyĭ tsentr psikhicheskogo zdorovia RAMN, Moskva

Lezheĭko T.V.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN, Moskva

Tikhonov D.V.

Mental Health Research Center, Moscow, Russia

Ganisheva T.K.

Berezin N.B.

Alekseev Psychiatric Hospital №1, Moscow, Russia

Snegireva A.A.

GKUZ "Moskovskaia gorodskaia klinicheskaia psikhiatricheskaia bol'nitsa #1 im. N.A. Alekseeva", Moskva

Shemiakina T.K.

Close metadata

References:

  1. Kohler C, Walker J, Martin E, Healey K, Moberg P. Facial emotion perception in schizophrenia: a meta-analytic review. Schizophrenia Bulletin. 2010; 36(5):1009-1019. https://doi.org/10.1093/schbul/sbn192
  2. Kohler C, Hoffman L, Eastman L, Healey K, Moberg P. Facial emotion perception in depression and bipolar disorder: a quantitative review. Psychiatry Research. 2011;188(3):303-309. https://doi.org/10.1016/j.psychres.2011.04.019
  3. Collin L, Bindra J, Raju M, Gillberg C, Minnis H. Facial emotion recognition in child psychiatry: A systematic review. Research in Developmental Disabilities. 2013;34(5):1505-1520. https://doi.org/10.1016/j.ridd.2013.01.008
  4. Cuthbert B. Translating intermediate phenotypes to psychopathology: the NIMH Research Domain Criteria. Psychophysiology. 2014;51(12):1205-1206. https://doi.org/10.1111/psyp.12342
  5. Weiss E, Freudenthaler H, Fink A, Reiser E, Niederstätter H, Nagl S, Parson W, Papousek I. Differential Influence of 5-HTTLPR — Polymorphism and COMT Val158Met — Polymorphism on Emotion Perception and Regulation in Healthy Women. Journal of the International Neuropsychological Society. 2014;20(05):516-524. https://doi.org/10.1017/S135561771400023X
  6. Zhu B, Chen C, Moyzis R, Dong Q, Chen C, He Q, Stern HS, Li H, Li J, Li J, Lessard J, Lin C. Genetic Variations in the Dopamine System and Facial Expression Recognition in Healthy Chinese College Students. Neuropsychobiology. 2012;65(2):83-89. https://doi.org/10.1159/000329555
  7. Defrancesco M, Niederstätter H, Parson W, Oberacher H, Hinterhuber H, Canazei M, Bidner J, Deisenhammer EA, Kemmler G, Weiss EM, Marksteiner J. Influence of Serotonin Transporter Genotype and Catechol-O-Methyltransferase Val158Met Polymorphism on Recognition of Emotional Faces. Journal of the International Neuropsychological Society. 2011;17(06): 1014-1020. https://doi.org/10.1017/s135561771100097x
  8. Gohier B, Senior C, Radua J, El-Hage W, Reichenberg A, Proitsi P, Phillips M, Surguladze S. Genetic modulation of the response bias towards facial displays of anger and happiness. European Psychiatry. 2014;29(4):197-202. https://doi.org/10.1016/j.eurpsy.2013.03.003
  9. Tamm G, Kreegipuu K, Harro J. Perception of emotion in facial stimuli: The interaction of ADRA2A and COMT genotypes, and sex. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2016;64:87-95. https://doi.org/10.1016/j.pnpbp.2015.07.012
  10. Tylec A, Kucharska-Pietura K, Jeleniewicz W, Czernikiewicz A, Stryjecka-Zimmer M. Functional polymorphism of genes inactivating catecholamines and emotional deficits in paranoid schizophrenia. Psychiatria Polska. 2010;44:207-219.(In Polish).
  11. Alfimova MV, Golimbet VE, Korovaitseva GI, Lezheiko TV, Abramova LI, Aksenova EV, Bolgov MI. The effect of the serotonin transporter 5-HTTLPR polymorphism on the recognition of facial emotions in schizophrenia. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. 2014;114(1):42-48.(In Russ.) .
  12. Marsh A, Finger E, Buzas B, Soliman N, Richell R, Vythilingham M, Pine DS, Goldman D, Blair R. Impaired recognition of fear facial expressions in 5-HTTLPR S-polymorphism carriers following tryptophan depletion. Psychopharmacology. 2006;189(3):387-394. https://doi.org/10.1007/s00213-006-0581-2
  13. Antypa N, Cerit H, Kruijt A, Verhoeven F, Van der Does A. Relationships among 5-HTT genotype, life events and gender in the recognition of facial emotions. Neuroscience. 2011;172:303-313. https://doi.org/10.1016/j.neuroscience.2010.10.042
  14. Székely E, Herba C, Arp P, Uitterlinden A, Jaddoe V, Hofman A, Verhulst F, Hudziak J, Tiemeier H. Recognition of scared faces and the serotonin transporter gene in young children: the Generation R Study. Journal of Child Psychology and Psychiatry. 2011;52(12):1279-1286. https://doi.org/10.1111/j.1469-7610.2011.02423.x
  15. Owens M, Goodyer I, Wilkinson P, Bhardwaj A, Abbott R, Croudace T, Dunn V, Jones P, Walsh N, Ban M, Sahakian B. 5-HTTLPR and Early Childhood Adversities Moderate Cognitive and Emotional Processing in Adolescence. PLoS ONE. 2012;7(11):48482. https://doi.org/10.1371/journal.pone.0048482
  16. Koizumi A, Kitagawa N, Kondo H, Kitamura M, Sato T, Kashino M. Serotonin transporter gene-linked polymorphism affects detection of facial expressions. PLoS One. 2013;8(3):59074. https://doi.org/10.1371/journal.pone.0059074
  17. Bediou B, Asri F, Brunelin J, Krolak-Salmon P, D’amato T, Saoud M, Tazi I. Emotion recognition and genetic vulnerability to schizophrenia. The British Journal of Psychiatry. 2007;191(2):126-130. https://doi.org/10.1192/bjp.bp.106.028829
  18. Alfimova M, Abramova L, Barhatova A, Yumatova P, Lyachenko G, Golimbet V. Facial Affect Recognition Deficit as a Marker of Genetic Vulnerability to Schizophrenia. The Spanish Journal of Psychology. 2009;12(01):46-55. https://doi.org/10.1017/s1138741600001463
  19. Ruocco A, Reilly J, Rubin L, Daros A, Gershon E, Tamminga C, Pearlson G, Hill S, Keshavan M, Gur R, Sweeney J. Emotion recognition deficits in schizophrenia-spectrum disorders and psychotic bipolar disorder: Findings from the Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP) study. Schizophrenia Research. 2014;158(1-3):105-112. https://doi.org/10.1016/j.schres.2014.07.001
  20. Allott K, Rice S, Bartholomeusz C, Klier C, Schlögelhofer M, Schäfer M, Amminger G. Emotion recognition in unaffected first-degree relatives of individuals with first-episode schizophrenia. Schizophrenia Researh. 2015;161(2-3):322-328. https://doi.org/10.1016/j.schres.2014.12.010
  21. Corcoran C, Keilp J, Kayser J, Klim C, Butler P, Bruder G, Gur R, Javitt D. Emotion recognition deficits as predictors of transition in individuals at clinical high risk for schizophrenia: a neurodevelopmental perspective. Psychological Medicine. 2015;45(14):2959-2973. https://doi.org/10.1017/s0033291715000902
  22. Greenwood T, Braff D, Light G, Cadenhead K, Calkins M, Dobie D, Freedman R, Green M, Gur R, Gur R, Mintz J, Nuechterlein K, Olincy A, Radant A, Seidman L, Siever L, Silverman J, Stone W, Swerdlow N, Tsuang D, Tsuang M, Turetsky B, Schork N. Initial Heritability Analyses of Endophenotypic Measures for Schizophrenia. Archive of General Psychiatry. 2007;64(11):1242. https://doi.org/10.1001/archpsyc.64.11.1242-1250
  23. Glahn D, Williams J, McKay D, Knowles E, Sprooten E, Mathias S, Curran J, Kent J, Carless M, Göring H, Dyer T, Woolsey M, Winkler A, Olvera R, Kochunov P, Fox P, Duggirala R, Almasy L, Blangero J. Discovering Schizophrenia Endophenotypes in Randomly Ascertained Pedigrees. Biological Psychiatry. 2015;77(1):75-83. https://doi.org/10.1016/j.biopsych.2014.06.027
  24. Greenwood T, Light G, Swerdlow N, Radant A, Braff D. Association Analysis of 94 Candidate Genes and Schizophrenia-Related Endophenotypes. PLoS ONE. 2012;7(1):29630. https://doi.org/10.1371/journal.pone.0029630
  25. Greenwood T, Swerdlow N, Gur R, Cadenhead K, Calkins M, Dobie D, Freedman R, Green M, Gur R, Lazzeroni L, Nuechterlein K, Olincy A, Radant A, Ray A, Schork N, Seidman L, Siever L, Silverman J, Stone W, Sugar C, Tsuang D, Tsuang M, Turetsky B, Light G, Braff D. Genome-Wide Linkage Analyses of 12 Endophenotypes for Schizophrenia From the Consortium on the Genetics of Schizophrenia. American Journal of Psychiatry. 2013;170(5):521-532. https://doi.org/10.1176/appi.ajp.2012.12020186
  26. Laruelle M, Frankle W, Narendran R, Kegeles L, Abi-Dargham A. Mechanism of action of antipsychotic drugs: From dopamine D2 receptor antagonism to glutamate NMDA facilitation. Clinical Therapeutics. 2005;27:16-24. https://doi.org/10.1016/j.clinthera.2005.07.017
  27. Iasevoli F, Tomasetti C, F. Buonaguro E, de Bartolomeis A. The Glutamatergic Aspects of Schizophrenia Molecular Pathophysiology: Role of the Postsynaptic Density, and Implications for Treatment. Current Neuropharmacology. 2014;12(3):219-238. https://doi.org/10.2174/1570159X12666140324183406
  28. Howes O, McCutcheon R, Stone J. Glutamate and dopamine in schizophrenia: An update for the 21st century. Journal of Psychopharmacology. 2015;29(2):97-115. https://doi.org/10.1177/0269881114563634
  29. Litvinenko VI, Odinak MM. Pathogenetic bases of cognitive and psychotic disorders in Parkinson’s disease. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. 2004;104(4):72-76. (In Russ.) .
  30. Cepeda C, Andre V, Jocoy E, Levine M. NMDA and dopamine: diverse mechanisms applied to interacting receptor systems. In Vandongen AM, ed. The Biology of the NMDA Receptor. Boca Raton, FL: Taylor & Francis Group; 2008;41-57.
  31. Martina M, Bergeron R. D1 and D4 dopaminergic receptor interplay mediates coincident G protein-independent and dependent regulation of glutamate NMDA receptors in the lateral amygdala. Journal of Neurochemistry. 2008;106(6):2421-2435. https://doi.org/10.1111/j.1471-4159.2008.05584.x
  32. Allen N, Bagade S, McQueen M, Ioannidis J, Kavvoura F, Khoury M, Tanzi R, Bertram L. Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database. Nature Genetics. 2008;40(7):827-834. https://doi.org/10.1038/ng.171
  33. Thompson J, Thomas N, Singleton A, Piggott M, Lloyd S, Perry E, Morris C, Perry R, Ferrier I, Court J. D2 dopamine receptor gene (DRD2) Taq1 A polymorphism: reduced dopamine D2 receptor binding in the human striatum associated with the A1 allele. Pharmacogenetics. 1997;7(6):479-484. https://doi.org/10.1097/00008571-199712000-00006
  34. Ebstein RP. The molecular genetic architecture of human personality: beyond self-report questionnaires. Molecular Psychiatry. 2006;11(5):427-445. https://doi.org/10.1038/sj.mp.4001814
  35. Mori F, Ribolsi M, Kusayanagi H, Siracusano A, Mantovani V, Marasco E, Bernardi G, Centonze D. Genetic variants of the NMDA receptor influence cortical excitability and plasticity in humans. Journal of Neurophysiology. 2011;106(4):1637-1643. https://doi.org/10.1152/jn.00318.2011
  36. Weickert C, Fung S, Catts V, Schofield P, Allen K, Moore L, Newell K, Pellen D, Huang X, Catts S, Weickert T. Molecular evidence of N-methyl-D-aspartate receptor hypofunction in schizophrenia. Molecular Psychiatry. 2012;18(11):1185-1192. https://doi.org/10.1038/mp.2012.137
  37. Alfimova MV, Golimbet VE, Korovaitseva GI, Lezheiko TV, Abramova LI, Kaleda VG. Polymorphism C366G in the GRIN2B gene and episodic verbal memory: a lack of the association in schizophrenia. Russian Journal of Genetics. 2016;52(6):622-625 . https://doi.org/10.1134/S102279541606003X
  38. Monakhov M, Golimbet V, Abramova L, Kaleda V, Karpov V. Association study of three polymorphisms in the dopamine D2 receptor gene and schizophrenia in the Russian population. Schizophrenia Research. 2008;100(1-3):302-307. https://doi.org/10.1016/j.schres.2008.01.007
  39. Alfimova M, Korovaitseva G, Lezheiko T, Golimbet V. Interaction Effects of the COMT and DRD4 Genes with Anxiety-Related Traits on Selective Attention. The Spanish Journal of Psychology. 2014;17. https://doi.org/10.1017/sjp.2014.46
  40. Petronis A, Van Tol H, Lichter J, Livak K, Kennedy J. The D4 dopamine receptor gene maps on 11p proximal to HRAS. Genomics. 1993;18(1):161-163. https://doi.org/10.1006/geno.1993.1445
  41. Wallwork R, Fortgang R, Hashimoto R, Weinberger D, Dickinson D. Searching for a consensus five-factor model of the Positive and Negative Syndrome Scale for schizophrenia. Schizophrenia Research. 2012;137(1-3):246-250. https://doi.org/10.1016/j.schres.2012.01.031
  42. Comparelli A, De Carolis A, Corigliano V, Di Pietro S, Trovini G, Granese C, Romano S, Serata D, Ferracuti S, Girardi P. Symptom correlates of facial emotion recognition impairment in schizophrenia. Psychopathology. 2014;47(1):65-70. https://doi.org/10.1159/000350453
  43. Li Y, Xi D, Roman J, Huang Y, Gao W. Activation of Glycogen Synthase Kinase-3 Is Required for Hyperdopamine and D2 Receptor-Mediated Inhibition of Synaptic NMDA Receptor Function in the Rat Prefrontal Cortex. Journal of Neuroscience. 2009;29(49):15551-15563. https://doi.org/10.1523/JNEUROSCI.3336-09.2009
  44. Gardoni F, Bellone C. Modulation of the glutamatergic transmission by Dopamine: a focus on Parkinson, Huntington and Addiction diseases. Frontiers in Cellular Neuroscience. 2015;9. https://doi.org/10.3389/fncel.2015.00025
  45. Ohtsuki T, Sakurai K, Dou H, Toru M, Yamakawa-Kobayashi K, Arinami T. Mutation analysis of the NMDAR2B (GRIN2B) gene in schizophrenia. Molecular Psychiatry. 2001;6(2):211-216. https://doi.org/10.1038/sj.mp.4000808
  46. Li D, He L. Association study between the NMDA receptor 2B subunit gene (GRIN2B) and schizophrenia: A HuGE review and meta-analysis. Genetics in Medicine. 2007;9(1):4-8. https://doi.org/10.1097/01.gim.0000250507.96760.4b
  47. Gareeva AE, Zakirov DA, Khusnutdinova KE. Association polymorphic variants of GRIN2B gene with paranoid schizophrenia and response to common neuroleptics in Russians and Tatars from Bashkortostan Republic. Russian Journal of Genetics. 2013; 49(9):962-968 . https://doi.org/10.1134/S1022795413080024
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