Treatment of chronic cerebral venous insufficiency: a study on an effect of L-lysine aescinat

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Chukanova E.I.

Rossiĭskiĭ gosudarstvennyĭ meditsinskiĭ universitet, Moskva

Mamayeva Kh.I.

Pirogov Russian National Research Medical University, Moscow

Chukanova A.S.

Treatment of chronic cerebral venous insufficiency: a study on an effect of L-lysine aescinat

Authors:

Chukanova E.I., Mamayeva Kh.I., Chukanova A.S.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2016;116(7): 37‑41

DOI: 10.17116/jnevro20161167137-41

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To cite this article:

Chukanova EI, Mamayeva KhI, Chukanova AS. Treatment of chronic cerebral venous insufficiency: a study on an effect of L-lysine aescinat. S.S. Korsakov Journal of Neurology and Psychiatry. 2016;116(7):37‑41. (In Russ.)
https://doi.org/10.17116/jnevro20161167137-41

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)

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Abstract:

Objective: To study an effect of L-lysine aescinat on the dynamics of complaints, severity of neurological syndromes and parameters of cerebral blood flow estimated by transcranial doppler and duplex scanning in patients with chronic cerebral venous insufficiency (CCVI). Material and methods: Eighty patients with ultrasound-confirmed CCVI were examined. The basic group included 40 patients who received two treatment courses (intravenous drop-by-drop/stream introductions of L-lysine aescinat in the dose of 5ml during 7 days in 2nd and 30th days of examination). The comparison group consisted of 40 patients. Results and Conclusion: Treatment with L-lysine aescinat led to the significant decrease in complaints and improved the scores on the scales used in the study. There was an improvement in the cerebral hemodynamics (an increase of hemodynamic reserve and normalization of the linear blood flow velocity in deep veins) in the patients with CCVI. The safe profile of L-lysine aescinat used in recommended doses was confirmed.

Keywords:

chronic cerebral venous insufficiency

L-lysine aescinat

dehydratation

prothrombotic conditions

venous drainage system

Authors:

Chukanova E.I.

Rossiĭskiĭ gosudarstvennyĭ meditsinskiĭ universitet, Moskva

Mamayeva Kh.I.

Pirogov Russian National Research Medical University, Moscow

Chukanova A.S.

Close metadata

References:

Mchedlishvili GI. The spasm of cerebral vessels. Tbilisi: Izd-voMetsniereba; 1977. (In Russ.).
Burtsev EM, Sergievsky SB, Asratyan SA. Variations of cerebral arterial and venous angioarchitectonics indyscirculatory encephalopathy. 1999;99(4):45-47. (In Russ.)
Guenther G, Arauz A. Cerebral venous thrombosis: a diagnostic and treatment update. Neurologia. 2011;26(8):488-498.
Berdichevskii MYa. Venous circulatory pathology of the brain. M.: Meditsina; 1989. (In Russ.)
Shumilina MV. Violations of cerebral venous circulation with cardiovascular disease: Dis. ... d-ra med. nauk. M. 2002. (In Russ.)
Baracchini C, Perini P, Calabrese M, Causin F, Rinaldi F. No evidence of chronic cerebrospinal venous insufficiency at multiple sclerosis onset. Ann Neurol. 2011;69:90-99.
Canhao P, Falcao F, Ferro JM. Thrombolytics for cerebral sinus thrombosis: a systematic review. Cerebrovasc Dis. 2003;15:159-166. doi: 10.1159/000068833
Sirtori CR. Aescin: pharmacology, pharmacokinetics and therapeutic profile. Chem Pharm Bull (Tokyo). 2001;49(5):626-628.
Dzyak LA, Serko AG, Suk VM.L-Lysine aescinat - a step ahead of the curve in the intracranial hypertension. Mezhdunarnevrolzhurn. 2009;3:1-4. (In Russ.)
Usenko LV, Sliva VI, Krishtafor AA, Vorotilishchev SM. The use of L-lysine aescinat in relieving local edema in the cerebral and spinal neurosurgery and resuscitation. Novostimeditsiny i farmatsii. 2002;7-8:3 (In Russ.)
Chernii VI, Ostrovaya TV. Brain Ischemia and tserebroprotektsiya in the aspect of evidence-based medicine. Bіl', znebolyuvannya і іntensivna terapіya. 2006;1(d):16-21. (In Russ.)
Voloshin PV, Malakhov VA, Zagorodnyaya NA. Endothelial dysfunction in patients with cerebral ischemic stroke: sex, age, severity of the disease, new possibilities of medical correction. Mezhdunar nevrol zhurn. 2007;2:15-20. (In Russ.)
Likhachev SA, Voitov VV, Vaschilin VV. The experience of L-lysine aescinat usage in the treatment of neurologic manifestations of lumbar osteochondrosis. Meditsinskie novosti (Arkhiv). 2012;10:51-54. (In Russ.)
Doepp F, Lammert I, Hoffmann O, Einhaupl KM, Schreiber S, Valdueza JM. Venous collateral blood flow assessed by Doppler ultrasound after unilateral radical neck dissection. Ann Otorhinolaryngol. 2001;110(11):1055-1058. doi: 10.1177/000348940111001112
Valdueza JM, von Munster T, Hoffman O, Schreiber S, Einhaupl KM. Postural dependency of the cerebral venous outflow. Lancet. 2000;355(9199):200-201. doi: http://dx.doi.org/10.1016/S0140-6736(99)04804-7
Lelyuk VG, Lelyuk SE. Ultrasonic Angiology. M.: Real'noe Vremya; 2003. (In Russ.)
Nikitin YuM, Trukhanov AI. Doppler ultrasound diagnosis in the clinic. MIK. 2004;496. (In Russ.)
San Millan Ruiz D, Gailloud P, Rufenacht DA, Delavelle J, Henry F, Fasel JHD. The craniocervical venous system in relation to cerebral venous drainage. Am J Neuroradiol. 2002;23(9):1500-1508. http://www.ajnr.org/cgi/content/full/23/9/1500
Applied Statistics Handbook. In 2 Vols. T. 1. Trans. from English. Ed. Lloida E., Ledermana U., Tyurina Yu.N. M.: Finansy i statistika. 1989. (In Russ.).

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