The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-0604
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2025
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Shyshov A.S.

Chumakov Institute of Poliomyelitis and Viral Encephalitis

Bazarova M.V.

Infectious clinical hospital 1

Blank I.A.

Infectious clinical hospital 1

Pasyshnyuk E.P.

Infectious clinical hospital 1

Savrasova N.M.

Infectious clinical hospital 1

Shurenkova E.N.

Infectious clinical hospital 1

Podkolzin A.T.

Central Research Institute of Epidemiology

Enterovirus infections and meningitis in children

Authors:

Shyshov A.S., Bazarova M.V., Blank I.A., Pasyshnyuk E.P., Savrasova N.M., Shurenkova E.N., Podkolzin A.T.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2016;116(2): 9‑15

DOI: 10.17116/jnevro2016116219-15

Views: 4021

Downloaded: 49

Download PDF (RU)
Contact the author
Table of contents

ENTEROVIRUS INFECTIONS AND MENINGITIS IN CHILDREN
ENTEROVIRUS INFECTIONS AND MENINGITIS IN CHILDREN

To cite this article:

Shyshov AS, Bazarova MV, Blank IA, Pasyshnyuk EP, Savrasova NM, Shurenkova EN, Podkolzin AT. Enterovirus infections and meningitis in children. S.S. Korsakov Journal of Neurology and Psychiatry. 2016;116(2):9‑15. (In Russ.)
https://doi.org/10.17116/jnevro2016116219-15

Подписка 2025-2 (S.S. Korsakov Journal of Neurology and Psychiatry)
 
МСФ на ЯМ
Close metadata
Recommended articles:
Diagnosis of neuroinfections in children. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(11-2):51-59
The expe­rience of diagnosing Alzheimer’s disease based on the study of cere­brospinal fluid biomarkers. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(1):91-97

OBJECTIVE

To compare clinical characteristics in children with enterovirus infections (EVI) and meningitis with detailed characteristics of the changes in the content of cerebrospinal fluid (CSF) confirmed in the laboratory.

MATERIAL AND METHODS

The results of examinations of 97 children, aged from 2.5 to 15 years, 3 adolescents and 1 adult female patient with EVI were analyzed. Enterovirus RNA isolation and detection in feces and CSF was performed using PCR.

RESULTS AND CONCLUSION

Enterovirus RNA in CSF was detected in 44 children, including 3 patients with cytosis (5—7—19 cells in 3 mm3). The frequency and severity of symptoms in 42 patients with EVI and meningitis, 14 children with EVI without meningitis and 8 patients with ICD-10 «Meningitis unspecified» are presented. The initial CSF pleocytosis in 1—3 day (4—5 day for two-wave course) in EVI and meningitis was <100 in 4, from 100 to 1000 in 33, >1000 (max 3036) cells in 3 mm3 in 5 patients, including 15 with the predominance of neutrophils (from 77 to 97% in cytosis 114—2300 cells in 3 mm3). In the peripheral blood, leukocytosis 10.9—13.8×109/l was noted in 12 children and leukocytosis 14.4—18.7×109/l with the «left shift» in 7. Most of the children (n=37) with EVI and meningitis were discharged from the hospital within 10—17 days. The authors suggest the importance of including the variety of clinical presentations of EVI in the additional item «B10 Enterovirus infections» in upcoming ICD-11.

Keywords:

enterovirus infections
clinical forms
meningitis
cerebrospinal fluid
ICD-11
new item «B10»

Authors:

Shyshov A.S.

Chumakov Institute of Poliomyelitis and Viral Encephalitis

Bazarova M.V.

Infectious clinical hospital 1

Blank I.A.

Infectious clinical hospital 1

Pasyshnyuk E.P.

Infectious clinical hospital 1

Savrasova N.M.

Infectious clinical hospital 1

Shurenkova E.N.

Infectious clinical hospital 1

Podkolzin A.T.

Central Research Institute of Epidemiology

List of references:

  1. Lashkevich V.A. 100 years of studying poliomyelitis virus and nonpolyomyelitis enteroviruses. Voprosy of Virology. 2008;4:41-44. 
  2. Fomina S.G. The enterovirus landscape in children with acute intestinal infection: Author's dissertation ... Candidate of Biological Sciences. M. 2013.
  3. Pallansch M, Roos R. Enteroviruses: Polioviruses, Coxsackieviruses, Echoviruses and Newer Enteroviruses. Field,s Virology. 5 th ed. 2007;840-893. 
  4. Nosov S.D. Infectious diseases in children in the past and present. L.: Medicine; 1980.
  5. Futer D.S., Yakunin Y.A., Yampolskaya E.I. Results and prospects for the study of childhood neuroinfections. Materials of the report session of the Pediatric Institute. M. 1965;5-8. 
  6. Melnichuk P.V., Shtulman D.R. Infectious and parasitic diseases of the nervous system. In: Diseases of the nervous system. Ed. by N.N. Yakhno. M. 2007;1:322-323. 
  7. New poliovirus vaccines for use after polio eradication. WHO, Geneva. 2000;4-5. 
  8. Zucker M.B. Infectious diseases of the nervous system in children. Moscow: Medgiz; 1963;45-58. 
  9. Baroyan O.V. Intestinal viruses and their role in human infectious pathology. Soviet Medicine. 1961;1:53-64. 
  10. Zucker MB, Leshchinskaya EV. Epidemiology and clinic of epidemic serous meningitis. Soviet Medicine. 1960;10:10-16. 
  11. Yampolskaya E.I. To the clinic of lesions of the nervous system in ESNO-virus infection in children. S.S. Korsakov Journal of Neuropathology and Psychiatry. 1962;7:966-971. 
  12. Bichurina MA, Pyanikh VA, Novikova NA, Leonova NP, Klevtsova GA, Romanenkova NI, et al. Seasonal rise in the incidence of enterovirus meningitis in the Novgorod region. Infection and immunity. 2012;4:747-752. 
  13. Gulman LA, Martynova GL, Kutishova IA, Weitzel EV, Komarova BL. Clinical and epidemiological characteristics of enteroviral meningitis in children during the 2008-2009 morbidity rise. Pediatric Infections. 2010;2:12-15. 
  14. Eshmolov S.N., Sitnikov I.G., Melnikova I.M. Clinical and laboratory features of enteroviral meningitis in children in modern conditions (according to Yaroslavl Oblast). Epidemiology and Infectious Diseases. 2012;3:38-42. 
  15. Ivanova RA, Krivosheenko EM, Timchenko VN. Clinical features and complex therapy of serous meningitis caused by enteroviruses. Pediatr. 2010;2:47-51. 
  16. Komarova T.V., Gasilina E.S., Pozdnyakova E.A. Serous meningitis of enterovirus etiology in children: clinical features and disintoxication function of cerebrospinal fluid. Practical Medicine. 2009;39:121-124. 
  17. Mikhaylova EV, Steinberg AV, Eremeyeva IG Meningitis enterovirus etiology in children: current approaches to diagnosis and features of the clinical course. Infectious Diseases. 2008;1:31-34. 
  18. Onishchenko G.G., Novikova N.A., Efimov E.I., Knyagina O.I., Petrov E.Y., Novikov D.V. et al. A season of enterovirus serous meningitis in Nizhny Novgorod in 2007: molecular epidemiological aspects. Journal of Microbiology. 2009;2:24-30. 
  19. Dzholbunova Z.K. Clinical and epidemiological characteristics of enterovirus and meningococcal meningitis. Topical Questions of Medicine. 2011;4:6-9. 
  20. Archimbaud Ch, Ouchchane L, Mirand A, Chambon M, Demeocq F, Labbe A et al. Improvement of the management of infants, children and adults with a molecular diagnosis of Enterovirus meningitis during two observational study periods. PLoS One. 2013;8(7):68571. https://doi.org/10.1371/journal.pone.0068571
  21. Brunel D, Leveque N, Jacques J, Renois F, Motte J, Andreoletti L. Clinical and virological features of aseptic meningitis outbreak in Nort-Eastern France, 2005. J Clin Virol. 2008;42(2):225-228.  https://doi.org/10.1016/j.jcv.2008.02.008
  22. Cabrerizo M, Trallero G, Echevarria JE, Moreno-Docon A, Pena MJ, Perez-Ruiz M et al. Molecular characterization of enteroviruses associated with neurological infections in Spain, 2008. J Med Virol. 2013;85(11):1975-1977. https://doi.org/10.1002/jmv.23693
  23. Kim HJ, Kang B, Hwang S, Hong J, Kim K, Cheon DS. Epidemics of viral meningitis caused by echovirus 6 and 30 in Korea in 2008. Virol J. 2012;9:38.  https://doi.org/10.1186/1743-422x-9-38
  24. Khetsuriani N, La Monte-Fowlkes A, Oberste MS, Pallansch MA. Enterovirus Surveillance — United States, 1970—2005. MMWR Surveil Summ. 2006;55:1-20.  https://doi.org/10.1037/e540562006-001
  25. Meqdam MM, Khalousi MM, Shurman AAl. Enteroviral Meningitis in Northern Jordan: Prevalence and Association with Clinical Findings. J Med Virol. 2002;66:224-228.  https://doi.org/10.1002/jmv.2133
  26. Milia MG, Cerutti F, Gregori G, Burdino E, Fllice T, Ruggiero T et al. Recent outbreak of aseptic meningitis in Italy due to Echovirus 30 and phylogenetic relationship with other European circulating strains. J Clin Virol. 2013;58(3):579-583.  https://doi.org/10.1016/j.jcv.2013.08.023
  27. Patriquin G, Hatchette J, Forward K. Klinical presentation of patients with aceptic meningitis, factor influencing treatment and hospitalization, and consequences of enterovirus CSF polymerase chain reaction testing. Can J Infect Dis Med Microbiol. 2012;23(1):1-5. 
  28. Schumacher J-D, Chuard Ch, Renevey F, Matter L, Regamey C. Outbreak of Echovirus 30 Meningitis in Switzerland. Scand J Infect Dis. 1999;31:539-542.  https://doi.org/10.1080/00365549950164391
  29. Somekh E, Cesar K, Handsher R, Hanukoglu A, Dalal I. An outbreak of echovirus 13 meningitis in central Israel. Epidemiol Infect. 2003;130:257-262.  https://doi.org/10.1017/s095026880200818x
  30. Trallero G, Casas I, Avellon A, Perez C, Tenorio A, De La Loma A. First epidemic of aseptic meningitis due to echovirus type 13 among Spanish children. Epidemiol Infect. 2003;130:251-256.  https://doi.org/10.1017/s0950268802008191
  31. Volle R, Bailly JL, Mirand A, Pereira B, Marque-Juillet S, Chamdon M. et al. Variations in CSF viral loads by virus genotype in patients hospitalized with laboratory-confirmed enterovirus meningitis. J Infect Dis. 2014. https://doi.org/10.1093/infdis/jiu178
  32. Bartoshevich Ye.N., Zucker M.B., Leshchinskaya Ye.V., Sokolova I.S., Martynenko I.N., Andreeva L.S., Ashmarina Ye.E. Poliomyelitis-like paralytic diseases in children inoculated with live Sabin vaccine. Bulletin of the USSR Academy of Medical Sciences. 1963;6:16-21. 
  33. Leshchinskaya EV, Ashmarina EE, Martynenko IN, Andreeva LS, Gracheva LA Paralytic poliomyelitis and poliomyelitis-like diseases in children. Pediatrics. 1979;12:13-17. 
  34. Cheshik S.G. Enteroviral (nonpolio) diseases caused by Coxsackie and ESNO viruses. In In: Human Viral Diseases. Ed. by A.F. Bilibin. Moscow: Medgiz; 1967.
  35. Zucker M.B. Clinical neuropathology of childhood. Moscow: Medicine; 1972.
  36. Voroshilova M.K. Enteroviral infections of man. Moscow: Medicine; 1979.
  37. Melnick J., Wenner H. Enteroviruses. In: Laboratory diagnosis of viral and rickettsial diseases. E. Lennett, N. Schmidt, eds. Translated from English, Moscow: Medicine; 1974.
  38. Lukashov A.N. The role of recombination in the evolution of nonpolyomyelitis enteroviruses: Author's dissertation ... D. in medical sciences. M. 2006.
  39. Prevention of enterovirus (nepolio) infection. Sanitary and Epidemiological Rules SP 3.1.2950-11. Approved July 27, 2011 № 106. M. 2012.
  40. Weinstein I.I., Graschenkov N.I. Meningitis. M. 1962.
  41. Liopo T.V. Clinical and laboratory aspects of optimization of diagnosis of meningeal syndrome in neuroinfections: Author's dissertation ... D. in medical sciences. Grodno. 2013.
  42. Yampolskaya E.I., Sergeev D.V. The outbreak of enterovirus meningitis in Irkutsk and the region in 1964. Materials of the report session of the Pediatric Institute. M. 1965;16-17. 
  43. International Statistical Classification of Diseases (10th revision). WHO, Geneva. 1995;1:139-154. 

Close metadata

Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.