Association study of the Val158Met polymorphism of the catechol-O-methyltransferase gene and alcoholism and heroin dependence: the role of a family history

Kibitov A.O.

Laboratoriia molekuliarnoĭ genetiki Natsional'nogo nauchnogo tsentra narkologii, Moskva

Voskoboeva E.Iu.

Moskovskiĭ oblastnoĭ NII akusherstva i ginekologii

Brodianskiĭ V.M.

Laboratoriia molekuliarnoĭ genetiki Natsional'nogo nauchnogo tsentra narkologii, Moskva

Chuprova N.A.

Laboratoriia molekuliarnoĭ genetiki Natsional'nogo nauchnogo tsentra narkologii, Moskva

Smirnova E.V.

FGBU "Ivanovskiĭ nauchno-issledovatel'skiĭ institut materinstva i detstva im. V.N. Gorodkova" Minzdrava Rossii, Ivanovo, Rossiia

Association study of the Val158Met polymorphism of the catechol-O-methyltransferase gene and alcoholism and heroin dependence: the role of a family history

Authors:

Kibitov A.O., Voskoboeva E.Iu., Brodianskiĭ V.M., Chuprova N.A., Smirnova E.V.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2010;110(4): 84‑88

Downloaded: 24

Download PDF (RU)

Contact the author

Table of contents

To cite this article:

Kibitov AO, Voskoboeva EIu, Brodianskiĭ VM, Chuprova NA, Smirnova EV. Association study of the Val158Met polymorphism of the catechol-O-methyltransferase gene and alcoholism and heroin dependence: the role of a family history. S.S. Korsakov Journal of Neurology and Psychiatry. 2010;110(4):84‑88. (In Russ.)

Подписка 2025-2 (S.S. Korsakov Journal of Neurology and Psychiatry)

Close metadata

Recommended articles:

Features of parameters of cerebral hemodynamics in patients with alcoholism with different flexibility of cognitive functions. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(2):96-100

Xenon inhalation in persons with burdened alcohol past medical history: a series of cases from expert practice. Forensic Medical Expertise. 2024;(5):42-50

The aim of this study was to investigate the association the Val158Met polymorphism of the catechol-O-methyltransferase (COMT) gene and predisposition to alcoholism and heroin dependence. The authors genotyped DNA samples from 964 Russian males (395 alcoholics, 243 heroin addicts and 326 healthy controls). The association between the Val158Met COMT polymorphism and alcoholism was found in males with high density of family history (two or more blood relatives with alcoholism within the family). In this group, the frequency of a L (Met) allele was significantly higher in comparison with controls (p=0,001), patients without family history (p=0,034) and patients with the mild density of family history (p=0,0005). The frequency of the HH (ValVal) genotype was reduced as well compared to the controls (p=0,003). In the group of heroin addicts with the mild density of family history, there was a trend to lower frequency of the HH genotype (p=0,058) compared to patients without family history. The results suggest that the functional Val158Met COMT polymorphism is one of the significant markers of genetic predisposition to addiction diseases.

Keywords:

gene polymorphism

catechol-O-methyltransferase

alcoholism

heroin dependence

family history

Authors:

Kibitov A.O.

Laboratoriia molekuliarnoĭ genetiki Natsional'nogo nauchnogo tsentra narkologii, Moskva

Voskoboeva E.Iu.

Moskovskiĭ oblastnoĭ NII akusherstva i ginekologii

Brodianskiĭ V.M.

Laboratoriia molekuliarnoĭ genetiki Natsional'nogo nauchnogo tsentra narkologii, Moskva

Chuprova N.A.

Laboratoriia molekuliarnoĭ genetiki Natsional'nogo nauchnogo tsentra narkologii, Moskva

Smirnova E.V.

FGBU "Ivanovskiĭ nauchno-issledovatel'skiĭ institut materinstva i detstva im. V.N. Gorodkova" Minzdrava Rossii, Ivanovo, Rossiia

List of references:

Anokhina I.P., Ivanets N.N., Shamakina I.Yu. i dr. Sovremennye problemy genetiki zavisimosti ot psikhoaktivnykh veshchestv. Narkologiya 2004; 6: 76-83.
Anokhina I.P., Kibitov A.O., Shamakina I.Yu. Genetika zavisimosti ot psikhoaktivnykh veshchestv. Narkologiya Natsional'noe rukovodstvo. M: Geotar-Media 2008; 52-84.
Bochkov N.P., Asanov A.Yu., Aksenova M.G. i dr. Geneticheskie faktory v etiologii i patogeneze narkomanii. Narkologiya 2003; 1: 7-14.
Cao L., Li T., Liu X. Association study of heroin dependence and catechol-O-methyltransferase gene. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2003; 20: 2: 127-130.
Cloninger C.R., Sigvardsson S., Gilligan S.B. et al. Genetic heterogeneity and the classification of alcoholism. Adv Alcohol Subst Abuse 1988; 7: 3-4: 3-16.
Comings D.E., Blum K. Reward deficiency syndrome: genetic aspects of behavioral disorders. Prog Brain Res 2000; 126: 325-341.
Dawson D.A., Harford T.C., Grant B.F. Family history as a predictor of alcohol dependence. Alcohol Clin Exp Res 1992; 16: 3: 572-575.
Heinz A., Smolka M.N. The effects of catechol O-methyltransferase genotype on brain activation elicited by affective stimuli and cognitive tasks. Rev Neurosci 2006; 17: 3: 359-367.
Horowitz R., Kotler M., Shufman E. et al. Confirmation of an excess of the high enzyme activity COMT val allele in heroin addicts in a family-based haplotype relative risk study. Am J Med Genet 2000; 96: 5: 599-603.
Ishiguro H., Haruo Shibuya T., Toru M. et al. Association study between high and low activity polymorphism of catechol-O-methyltransferase gene and alcoholism. Psychiat Genet 1999; 9: 3: 135-138.
Kauhanen J., Hallikainen T., Tuomainen T.P. et al. Association between the functional polymorphism of catechol-O-methyltransferase gene and alcohol consumption among social drinkers. Alcohol Clin Exp Res 2000; 24: 2: 135-139.
Kweon Y.S., Lee H.K., Lee C.T. et al. Association study of catechol-O-methyltransferase gene polymorphism in Korean male alcoholics. Psychiat Genet 2005; 15: 2: 151-154.
Mattay V.S., Goldberg T.E., Fera F. et al. Catechol O-methyltransferase Val158-met genotype and individual variation in the brain response to amphetamine. Proc Natl Acad Sci USA 2003; 100: 10: 6186-6191.
Nestler E. Molecular mechanisms of Drug addiction. J Neuroscience 1992; 12: 7: 2439-2450.
Noble E.P. Alcoholism and the dopaminergic system: a review. Addict Biol 1996; 1: 4: 333-348.
Rothhammer F., Rothhammer P., Llop E. Genetics of addictive disorders. Rev Med Chil 2000; 128: 11: 1279-1282.
Schuckit M.A. Twin studies in substance abuse: An overview. Twin research 3. Epidemiological and Clinical studies. New York: Alan R Liss Inc 1981; 68-71.
Sery O., Didden W., Mikes V. et al. The association between high-activity COMT allele and alcoholism. Neuro Endocrinol Lett 2006; 27: 1-2: 231-235.
Tiihonen J., Hallikainen T., Lachman H. et al. Association between the functional variant of the catechol-O-methyltransferase (COMT) gene and type 1 alcoholism. Mol Psychiat 1999; 4: 3: 286-289.
Vandenbergh D.J., Rodriguez L.A., Miller I.T. et al. High-activity catechol-O-methyltransferase allele is more prevalent in polysubstance abusers. Am J Med Genet 1997; 74: 4: 439-442.
Vanyukov M.M., Tarter R.E. Genetic studies of substance abuse. Drug and Alcohol Dependence 2000; 59: 101-123.
Wang T., Franke P., Neidt H. et al. Association study of the low-activity allele of catechol-O-methyltransferase and alcoholism using a family-based approach. Mol Psychiat 2001; 6: 1: 109-111.

Close metadata