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Shchepareva M.E.

Research Center of Neurology, Moscow, Russia

Skalnaya A.A.

Research Center of Neurology, Moscow, Russia

Zakharova M.N.

Research Center of Neurology, Moscow, Russia

Shabalina A.A.

Research Center of Neurology

Clinical and biochemical characteristics of atypical variants of multiple sclerosis

Authors:

Shchepareva M.E., Skalnaya A.A., Zakharova M.N., Shabalina A.A.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2019;119(10‑2): 81‑86

DOI: 10.17116/jnevro201911910281

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Table of contents

CLINICAL AND BIOCHEMICAL CHARACTERISTICS OF ATYPICAL VARIANTS OF MULTIPLE SCLEROSIS
CLINICAL AND BIOCHEMICAL CHARACTERISTICS OF ATYPICAL VARIANTS OF MULTIPLE SCLEROSIS

To cite this article:

Shchepareva ME, Skalnaya AA, Zakharova MN, Shabalina AA. Clinical and biochemical characteristics of atypical variants of multiple sclerosis. S.S. Korsakov Journal of Neurology and Psychiatry. 2019;119(10‑2):81‑86. (In Russ.)
https://doi.org/10.17116/jnevro201911910281

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова. Спецвыпуски (S.S. Korsakov Journal of Neurology and Psychiatry (special issues))
 
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Abstract:

Objective. To study the clinical and biochemical features of atypical variants of multiple sclerosis (MS) (tumefactive demyelination (TD), Balo’s concentric sclerosis (BCS)) and acute disseminated encephalomyelitis (ADEM)). Material and methods. Forty-two patients were studied, including 32 patients with atypical variants of MS (6 patients with BCS and 26 patients with TD) and 10 patients with ADEM. The control group included 20 healthy volunteers. Clinical characteristics and EDSS scores were evaluated. Antibodies to aquaporin 1 (AQP1-IgG), aquaporin 4 (AQP4-IgG), antibodies to myelin oligodendrocyte glycoprotein (MOG-IgG) and aquaporin 1 (AQP1) in serum and cerebrospinal fluid (CSF) were detected using ELISA. Results and conclusion. BCS and TD occurred both in isolation and comorbid with MS (in 50% of cases with BCS, 50% of cases with TD). Atypical symptoms of MS were detected in 50% of cases of CFS, 15.4% of cases of PD. The levels of CSF cytosis and CSF protein were not significantly different between the groups. The levels of AQP1-IgG, AQP4-IgG, AQP1, MOG-IgG in serum with BCS, TD and ADEM were significantly higher than in the control group. No significant differences were found between atypical variants of MS. A correlation between a high level of MOG-IgG and the EDSS score in BCS was shown. MOG-IgG may have a pathogenetic significance in BCS. Further studies of AQP1-IgG, AQP4-IgG and MOG-IgG in patients with atypical variants of MS are needed.

Keywords:

atypical variants of multiple sclerosis
Balo’s concentric sclerosis
tumefactive demyelination
antibodies to myelin-oligodendrocyte glycoprotein
aquaporin 1-antibodies
aquaporin 4-antibodies
aquaporin 1

Authors:

Shchepareva M.E.

Research Center of Neurology, Moscow, Russia

Skalnaya A.A.

Research Center of Neurology, Moscow, Russia

Zakharova M.N.

Research Center of Neurology, Moscow, Russia

Shabalina A.A.

Research Center of Neurology

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References:

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