Both treatment and effective rehabilitation play an important role in preserving the reproductive health of the girl, the future mother. Along with the search for new drug therapies for various gynecological pathologies, it is important to use physical and natural factors that are natural stimuli for the patient’s body. Aim of this study was to examine the effect of health resort factors and methods of physiotherapy on the general condition and hormonal status of girls with delayed sexual development. Materials and methods. 83 patients with delayed sexual development who were examined at the children’s clinical sanatorium «Zdravnitsa» in Yevpatoria (Crimea) were examined: 52 girls were included in the primary group, 31 — in the comparison group. Both groups, depending on age, were divided into subgroups: 13—14 years old and 15—17 years old. Patients in both groups received a standard treatment complex (STC). In addition to SCR, the girls of the main group were prescribed: 5% brine electrophoresis by sinusoidal modulated currents, sage and sea baths. The control group included gynecologic ally healthy adolescents: thirteen 13—14 year-old girls old in the subgroup K1 and twelve 15—17 year-old girls in the subgroup K2. Before and after treatment, all patients underwent standard clinical, gynecological, and laboratory examinations. In both groups, the dynamics of clinical and laboratory parameters, as well as gonadotropic and sex steroid hormones in the blood serum were analyzed. Results. The complex of climatic and physical factors had a nonspecific general stimulating effect. There was a positive dynamics in the general condition of patients, their anthropometric indicators, hormonal status, which was more pronounced in the primary group than in the comparison group. Negative dynamics of the course of diseases in girls of both groups was not observed. Conclusion. The use of hardware physiotherapy and sage baths increases the effectiveness of STC. The best clinical and laboratory dynamics of the primary indices was noted in patients 13—14 years old than in patients 15—17 years old. The use of natural and preformed physical factors in treatment makes it possible to minimize the drug effect on the body and achieve the most positive treatment results with a minimum of side effects.