Possibilities of differential diagnosis of chronic diseases of the nasal cavity after surgical treatment and topical antibiotic therapy

Karpishchenko S.A.

Pavlov First St. Petersburg State Medical University

ORCID: 0000-0003-1124-1937

Zubareva A.A.

Pavlov First St. Petersburg State Medical University

ORCID: 0000-0003-1567-4860

Bolozneva E.V.

Pavlov First St. Petersburg State Medical University

ORCID: 0000-0003-0086-1997

Savchenko E.M.

Pavlov First St. Petersburg State Medical University

ORCID: 0000-0003-3518-3073

Zueva E.A.

Pavlov First St. Petersburg State Medical University

ORCID: 0000-0002-7740-2556

Possibilities of differential diagnosis of chronic diseases of the nasal cavity after surgical treatment and topical antibiotic therapy

Authors:

Karpishchenko S.A., Zubareva A.A., Bolozneva E.V., Savchenko E.M., Zueva E.A.

More about the authors

Journal: Russian Bulletin of Otorhinolaryngology. 2023;88(2): 44‑50

DOI: 10.17116/otorino20228802144

Downloaded: 68

Download PDF (RU)

Contact the author

Table of contents

To cite this article:

Karpishchenko SA, Zubareva AA, Bolozneva EV, Savchenko EM, Zueva EA. Possibilities of differential diagnosis of chronic diseases of the nasal cavity after surgical treatment and topical antibiotic therapy. Russian Bulletin of Otorhinolaryngology. 2023;88(2):44‑50. (In Russ.)
https://doi.org/10.17116/otorino20228802144

Подписка 2025 (Russian Bulletin of Otorhinolaryngology)

Close metadata

OBJECTIVE

The study was performed to assess the endoscopic state of the nasal mucosa after the use of local anti-inflammatory and antibacterial therapy, in particular, Polydexa nasal spray with phenylephrine containing Dexamethasone sodium metasulfobenzoate + Neomycin + Polymyxin B + Phenylephrine, and for the treatment of granulomatosis with polyangiitis.

MATERIAL AND METHODS

The study included 940 patients who underwent examination and treatment for chronic rhinosinusitis in the clinic of otorhinolaryngology of I.P. Pavlov SPbSMU surgical treatment of the paranasal sinuses underwent 907 patients. In the postoperative period, the first group (211 patients) underwent toileting of the nasal cavity. The second group (307 patients) received irrigation therapy. The third group (389 patients) received a topical treatment combined of Polydexa with phenylephrine. The dynamics of the condition was assessed on the 1st, 3rd and 7th days of treatment, the evaluation of the effectiveness of the treatment was carried out on the 3rd and 7th days. Differential diagnosis with granulomatosis with polyangiitis was carried out in 33 patients. All patients with granulomatosis with polyangiitis showed signs of chronic rhinosinusitis. Patients were prescribed local anti-inflammatory and antibacterial therapy with Polydexa with phenylephrine for 7 days with endoscopic control of the nasal cavity.

CONCLUSION

The use of the combined topical drug Polydexa with phenylephrine in patients with chronic rhinosinusitis and in patients with granulomatosis with polyangiitis has a positive effect, which reduces the clinical manifestations of chronic rhinosinusitis.

Keywords:

chronic rhinosinusitis

granulomatosis with polyangiitis

topic antibacterial management

Authors:

Karpishchenko S.A.

Pavlov First St. Petersburg State Medical University

ORCID: 0000-0003-1124-1937

Zubareva A.A.

Pavlov First St. Petersburg State Medical University

ORCID: 0000-0003-1567-4860

Bolozneva E.V.

Pavlov First St. Petersburg State Medical University

ORCID: 0000-0003-0086-1997

Savchenko E.M.

Pavlov First St. Petersburg State Medical University

ORCID: 0000-0003-3518-3073

Zueva E.A.

Pavlov First St. Petersburg State Medical University

ORCID: 0000-0002-7740-2556

Received:

23.01.2023

Accepted:

03.04.2023

List of references:

Karpishchenko SA, Lavrenova GV, Kulikova OA, Kucherova LR, Zubareva AA, Arustamyan IG. Wegener’s granulomatosis. Folia Otorhinolaryngologiae et Pathologiae Respiratoriae. 2016;4:42-55. (In Russ.).
Karpishchenko SA, Aleksandrov AN, Bolozneva EV, Fatalieva AF. The course of acute purulent polysinusitis in a patient with granulomatosis with polyangiitis. Folia Otorhinolaryngologiae et Pathologiae Respiratoriae. 2017;2:80-87. (In Russ.).
Lopatin AS. Chronic rhinosinusitis: global trends and national characteristics. Poslediplomnoe obrazovanie v otorinolaringologii. 2018;6:2-27. (In Russ.).
Fokkens WJ, Lund VJ, Hopkins C, Hellings PW, Kern R, Reitsma S, Toppila-Salmi S, Bernal-Sprekelsen M, Mullol J, Alobid I, Anselmo-Lima WT, Bachert C, Baroody F, vonBuchwald C, Cervin A, Cohen N, Constantinidis J, DeGabory L, Desrosiers M, Diamant Z, Douglas RG, Gevaert PH, Hafner A, Harvey RJ, Joos GF, Kalogjera L, Knill A, Kocks JH, Landis BN, Limpens J, Lebeer S, Lourenco O, Meco C, Matricardi PM, O’Mahony L, Philpott CM, Ryan D, Schlosser R, Senior B, Smith TL, Teeling T, Tomazic PV, Wang DY, Wang D, Zhang L, Agius AM, Ahlstrom-Emanuelsson C, Alabri R, Albu S, Alhabash S, Aleksic A, Aloulah M, Al-Qudah M, Alsaleh S, Baban MA, Baudoin T, Balvers T, Battaglia P, Bedoya JD, Beule A, Bofares KM, Braverman I, Brozek-Madry E, Richard B, Callejas C, Carrie S, Caulley L, Chussi D, deCorso E, Coste A, El Hadi U, Elfarouk A, Eloy PH, Farrokhi S, Felisati G, Ferrari MD, Fishchuk R, Grayson W, Goncalves PM, Grdinic B, Grgic V, Hamizan AW, Heinichen JV, Husain S, Ping TI, Ivaska J, Jakimovska F, Jovancevic L, Kakande E, Kamel R, Karpischenko S, Kariyawasam HH, Kawauchi H, Kjeldsen A, Klimek L, Krzeski A, Kopacheva-Barsova G, Kim SW, Lal D, Letort JJ, Lopatin A, Mahdjoubi A, Mesbahi A, Netkovski J, NyenbueTshipukane D, Obando-Valverde A, Okano M, Onerci M, Ong YK, Orlandi R, Otori N, Ouennoughy K, Ozkan M, Peric A, Plzak J, Prokopakis E, Prepageran N, Psaltis A, Pugin B, Raftopulos M, Rombaux P, Riechelmann H, Sahtout S, Sarafoleanu CC, Searyoh K, Rhee CS, Shi J, Shkoukani M, Shukuryan AK, Sicak M, Smyth D, Sindvongs K, SoklicKosak T, Stjarne P, Sutikno B, Steinsvag S, Tantilipikorn P, Thanaviratananich S, Tran T, Urbancic J, Valiulius A, VasquezdeAparicio C, Vicheva D, Virkkula PM, Vicente G, Voegels R, Wagenmann MM, Wardani RS, Welge-Lussen A, Witterick I, Wright E, Zabolotniy D, Zsolt B, Zwetsloot CP. European Position Paper on Rhinosinusitis and Nasal Polyps 2020. Rhinology. 2020;58(Suppl 29):1-464. https://doi.org/10.4193/Rhin20.600
Shilenkova VV, Shilenkov KA. EPOS-2020. What’s new? Rossijskaya rinologiya. 2020;28(2):94-100. (In Russ.). https://doi.org/10.17116/rosrino20202802194
Shmeleva NV. Varianty konservativnogo i khirurgicheskogo lecheniya khronicheskikh sinusitov: Diss. ... kand. med. nauk. SPb; 2009. (In Russ.)
Savlevich EL, Pelishenko TG, Kozlov VS, Koryagin FN, Koryagina TS. Management of patients in the perioperative period during operations in the nasal cavity and paranasal sinuses. Rossijskaya otorinolaringologiya. 2021;20(4-113):102-109. (In Russ.). https://doi.org/10.18692/1810-4800-2021-4-102-109
Ramakrishnan Y, Shields RC, Elbadawey MR, Wilson JA. Biofilms in chronic rhinosinusitis: what is new and where next? The Journal of Laryngology and Otology. 2015;129(8):744-751. https://doi.org/10.1017/S0022215115001620
Ivanchenko OA, Karpishchenko SA, Kozlov RS, Krechikova OI, Otvagin IV, Sopko ON, Piskunov GZ, Lopatin AS. The microbiome of the maxillary sinus and middle nasal meatus in chronic rhinosinusitis. Rhinology. 2016;54(1):68-74. https://doi.org/10.4193/Rhino15.018
Jankowski R, Gallet P, Nguyen DT, Rumeau C. Chronic rhinosinusitis of adults: new definition, new diagnosis. RevPrat. 2019; 69(3):274-278.
Chibisova MA, Fadeev RA, Zubareva AA. Trekhmernye tsifrovye tekhnologii v diagnostike i kontrole lecheniya zabolevanij chelyustno-litsevoj oblasti. SPb: Chelovek; 2022. (In Russ.).
Charakorn N, Snidvongs K. Chronic sphenoid rhinosinusitis: management challenge. Journal of Asthma and Allergy. 2016;9:199-205. https://doi.org/10.2147/JAA.S93023
Karpishchenko SA, Vereshchagina OE, Karpov AA. Endoscopic septum surgery as a stage of endonasal dacryocystorinostomy. Vestnik otorinolaringologii. 2020;85(6):56-59. (In Russ.). https://doi.org/10.17116/otorino2020850615612
Karpishchenko SA, Bolozneva EV, Bibik PR, Karpishchenko ES. The possibilities of computer-assisted navigation systems in the surgical treatment of chronic sinusitis, neoplasms of the nasal cavity and paranasal sinuses. Vestnik otorinolaringologii. 2019;84(4):6-12. (In Russ.). https://doi.org/10.17116/otorino201984041613
Khronicheskij rinosinusit: patogenez, diagnostika i printsipy lecheniya (klinicheskie rekomendatsii). Lopatin AS, ed. Rossijskoe obshchestvo rinologov. M.: Prakticheskaya meditsina; 2014. Accessed January 06, 2023. (In Russ.). https://www.osp.ru/netcat_files/userfiles/lvrach/Sinusit-recommendations.pdf
Adam SD, Timothy LS. Outcomes after Frontal Sinus Surgery: An Evidence-Based Review. Otolaryngologic Clinics of North America. 2016;49(4):1019-1033.
Aleksandrov AN, Karpishchenko SA, Vereshchagina OE, Bolozneva EV, Shchelkunova MA. Topical agents for postoperative wound care in endoscopic rhinosurgery. Folia Otorhinolaryngologiae et Pathologiae Respiratoriae. 2021;27(3):57-62. (In Russ.). https://doi.org/10.33848/foliorl23103825-2021-27-3-57-52
Rudmik L, Hoy M, Schlosser RJ, Harvey RJ, Welch KC, Lund V, Smith TL. Topical therapies in the management of chronic rhinosinusitis: an evidence-based review with recommendations. International Forum of Allergy and Rhinology. 2013;3(4):281-298. https://doi.org/10.1002/alr.21096
Trimarchi M, Sinico RA, Teggi R, Bussi M, Specks U, Meroni PL. Otorhinolaryngological manifestations in granulomatosis with polyangiitis (Wegener’s). Autoimmunity Reviews. 2013;12(4):501-505. https://doi.org/10.1016/j.autrev.2012.08.010
Hernández-Rodríguez J, Hoffman GS, Koening CL. Surgical interventions and local therapy for Wegener’s granulomatosis. Current Opinion in Rheumatology. 2010;22:29-36. https://doi.org/10.1097/BOR.0b013e328333e9e9

Close metadata