Features of topical therapy of inflammatory pathology of nasal cavity

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Treatment of inflammatory pathology of the nasal cavity at the present stage requires a doctor to clearly understand the physiological mechanisms that implement the main functions of the mucous membrane of the nasal cavity and upper respiratory tract. One of the most important processes that ensure the normal functioning of the respiratory tract is mucociliary clearance. Violations of its work leads to stagnation of mucus and the development of inflammation not only in the nasal cavity, but also in the lower respiratory tract and middle ear cavities. The authors of the article consider the main etiological factors and mechanisms of the pathogenesis of inflammatory diseases of the nasal cavity, discuss approaches to the treatment of these conditions. The authors conclude that in conditions of acute and chronic inflammation of the nasal mucosa, accompanied by the secretion of thick viscous mucus, the most effective topical use of the combined preparation, which includes acetylcysteine, tuaminoheptane and sodium hyaluronate. This combination has both mucolytic, vasoconstrictive and protective effects, which increases the effectiveness of the drug and the adherence of patients to therapy.

Keywords:

inflammation

rhinitis

topical therapy

acetylcysteine

tuaminoheptane

hyaluronic acid

mucociliary clearance

Authors:

Gurov A.V.

N.I. Pirogov Russian National Research Medical University of the Ministry of Health of Russia;
Sverzhevsky Research Institute of Clinical Otorhinolaryngology

ORCID: 0000-0001-9811-8397

Yushkina M.A.

N.I. Pirogov Russian National Research Medical University of the Ministry of Health of Russia;
Sverzhevsky Research Institute of Clinical Otorhinolaryngology

ORCID: 0000-0002-9823-1047

Doronina O.M.

Pirogov Russian National Research Medical University;
Sverzhevsky Research Clinical Institute of Otorhinolaryngology

Received:

11.05.2022

Accepted:

23.05.2022

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