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Boklazhenko E.V.

East-Siberian Institute of Medical and Ecological Research

Bodienkova G.M.

East-Siberian Institute of Medical and Ecological Research

Assessment of the population and subpopulation composition of lymphocytes and their relationship in patients with sensorineural hearing loss

Authors:

Boklazhenko E.V., Bodienkova G.M.

More about the authors

Journal: Russian Bulletin of Otorhinolaryngology. 2021;86(2): 16‑20

DOI: 10.17116/otorino20218602116

Views: 5916

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Table of contents

To cite this article:

Boklazhenko EV, Bodienkova GM. Assessment of the population and subpopulation composition of lymphocytes and their relationship in patients with sensorineural hearing loss. Russian Bulletin of Otorhinolaryngology. 2021;86(2):16‑20. (In Russ.)
https://doi.org/10.17116/otorino20218602116

Подписка 2025 (Russian Bulletin of Otorhinolaryngology)
 
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Study of the role of the phenotypic composition of lymphocytes, shifts in which can cause the development of various pathological processes, including sensorineural hearing loss, is an important area of modern research. Purpose of the study. To study the population and subpopulation composition of lymphocytes and their intercellular cooperation in persons with occupational sensorineural hearing loss.

MATERIAL AND METHODS

Phenotyping of blood lymphocytes (CD3+, CD4+, CD8+, CD9+, CD16+, CD20+, CD21+, CD23+, CD25+, CD95+) was performed by indirect immunofluorescence.

RESULTS

Individuals with sensorineural hearing loss were found to have hyperactivation in both T- and B-cell links immunity.

CONCLUSIONS

The revealed changes indicate a violation of immunoregulation through factors of intercellular cooperation, and the established relationships between populations and subpopulations of lymphocytes indicate increased activity components of the immune system, their important role in the implementation of the immune response in persons with sensorineural hearing loss.

Keywords:

immune system
lymphocyte populations and subpopulations
the relationship of the cell composition of lymphocytes
professional sensorineural hearing loss

Authors:

Boklazhenko E.V.

East-Siberian Institute of Medical and Ecological Research

Bodienkova G.M.

East-Siberian Institute of Medical and Ecological Research

Received:

17.03.2020

Accepted:

24.05.2020

List of references:

  1. Pankov VA, Lakhman OL, Perezhogin AN, Tyutkina GA, Kuleshova MV, Smirnova OV. The dynamics of the occupational morbidity rate in the Eastern Siberia. Gigiena i sanitariya. 2016;12:1175-1179. (In Russ.). https://doi.org/10.18821/0016-9900-2016-95-12-1171-1175
  2. Sheshegov PM, Zinkin VN, Slivina LP. Aviation noise as a major factor contributing to morbidity and occupational risks for aviation maintenance personnel. Aviakosmicheskaya i ekologicheskaya meditsina. 2018;52(3):62-68. (In Russ.). https://doi.org/10.21687/0233-528X-2018-52-3-62-68
  3. Gong TW, Lomax MI. Genes that Influence Susceptibility to Noise-Induced Hearing Loss. In: Le Prell CG, Henderson D, Fay RR, Popper AN, eds. Noise-Induced Hearing Loss. Springer Handbook of Auditory Research. Vol 40. Springer, New York; 2012;179-203.  https://doi.org/10.1007/978-1-4419-9523-0_9
  4. Kosarev VV, Babanov SA. Professional neurosensory relative deafness. Rossiyskiy meditsinskiy zhurnal. 2012;20(31):1556-1560. (In Russ.).
  5. Savchenko AA, Zdzitovetskiy DE, Borisov AG, Luzan NA. Peculiarities of the cellular and humoral immunity status and the levels of concentrations of cytokines in patients with extensive purulent peritonitis. Sibirskoe meditsinskoe obozrenie. 2013;79(1):24-28. (In Russ.).
  6. Toomey CB, Kelly U, Saban DR, Bowes Rickman C. Regulation of age-related macular degeneration-like pathology by complement factor H. Proceedings of the National Academy of Sciences of the United States of America. 2015;112(23):3040-3049. https://doi.org/10.1073/pnas.1424391112
  7. Dhaliwal B, Pang MO, Keeble AH, James LK, Gould HJ, McDonnell JM, Sutton BJ, Beavil AJ. IgE binds asymmetrically to its B cell receptor CD23. Scientific Reports. 2017;7:45533. https://doi.org/10.1038/srep45533
  8. Pankova VB, Podol’skaya EV. Criteria for the risk of noise damage to the hearing organ. Vestnik otorinolaringologii. 1991;3:63-67. (In Russ.).
  9. Kim JH, Kim GE, Cho GS, Kwon HJ, Joo CH, Kim HS, JangYJ. Natural killer cells have impaired effector functions. PLoS One. 2013;8(10):77177. https://doi.org/10.1371/journal.pone.0077177
  10. Sarkisov DS. Strukturnye osnovy adaptacii i kompensacii narushennyh funkcij. M.: Medicina; 1986. (In Russ.).

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