Dynamics of activity of neurokinine receptors and enzymes of intercellular matrix (MMP9 and TIMP-2) in the nasal mucosa of the chronic cigarette smokers

Lepeĭko Iu.B.

TsNIL Tikhookeanskogo gosudarstvennogo meditsinskogo universiteta, Vladivostok, Rossiia, 690105

Diuĭzen I.V.

TsNIL Tikhookeanskogo gosudarstvennogo meditsinskogo universiteta, Vladivostok, Rossiia, 690105

Nevzorova V.A.

Pacific State Medical University, Vladivostok, Russia

Gilifanov E.A.

Kafedra otorinolaringologii Vladivostokskogo gosudarstvennogo meditsinskogo universiteta Minzdrava Rossii

Dynamics of activity of neurokinine receptors and enzymes of intercellular matrix (MMP9 and TIMP-2) in the nasal mucosa of the chronic cigarette smokers

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Lepeĭko Iu.B., Diuĭzen I.V., Nevzorova V.A., Gilifanov E.A.

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Journal: Russian Bulletin of Otorhinolaryngology. 2014;(3): 12‑16

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Lepeĭko IuB, Diuĭzen IV, Nevzorova VA, Gilifanov EA. Dynamics of activity of neurokinine receptors and enzymes of intercellular matrix (MMP9 and TIMP-2) in the nasal mucosa of the chronic cigarette smokers. Russian Bulletin of Otorhinolaryngology. 2014;(3):12‑16. (In Russ.)

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The present study was designed to determine localization of substance P and neuroknine receptors in the nasal mucous membrane of the subjects having the history of chronic smoking. The mechanisms underlying reorganization of the mucous tissue were elucidated by measuring the activity of intercellular matrix enzymes (MMP9 and TIMP-2). The activity of neurokinine receptors localized on the cells of ciliary epithelium and in the connective tissue elements of the submucous structures was shown to be significantly increased. It is concluded that the specific dynamics of MMP9 and TIMP-2 activities in the chronic cigarette smokers indicates that the matrix metalloproteinases of this type play an important role in the structural reorganization of the tissues of the nasal mucous membrane.

Keywords:

neurogenic inflammation

neurokinine receptors

substance P

matrix metalloproteinases

tissue inhibitors of matrix metalloproteinases

nasal mucous membrane

Authors:

Lepeĭko Iu.B.

TsNIL Tikhookeanskogo gosudarstvennogo meditsinskogo universiteta, Vladivostok, Rossiia, 690105

Diuĭzen I.V.

TsNIL Tikhookeanskogo gosudarstvennogo meditsinskogo universiteta, Vladivostok, Rossiia, 690105

Nevzorova V.A.

Pacific State Medical University, Vladivostok, Russia

Gilifanov E.A.

Kafedra otorinolaringologii Vladivostokskogo gosudarstvennogo meditsinskogo universiteta Minzdrava Rossii

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