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Yartsev V.D.

Krasnov Research Institute of Eye Diseases, Moscow, Russia

Atkova E.L.

Krasnov Research Institute of Eye Diseases, Moscow, Russia

Efremenko M.A.

Krasnov Research Institute of Eye Diseases, Moscow, Russia

Prospects for the use of depot drug formulations in dacryology

Authors:

Yartsev V.D., Atkova E.L., Efremenko M.A.

More about the authors

Journal: Russian Annals of Ophthalmology. 2026;142(3): 63‑69

DOI: 10.17116/oftalma202614203163

Read: 254 times

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Table of contents

PROSPECTS FOR THE USE OF DEPOT DRUG FORMULATIONS IN DACRYOLOGY
PROSPECTS FOR THE USE OF DEPOT DRUG FORMULATIONS IN DACRYOLOGY

To cite this article:

Yartsev VD, Atkova EL, Efremenko MA. Prospects for the use of depot drug formulations in dacryology. Russian Annals of Ophthalmology. 2026;142(3):63‑69. (In Russ.)
https://doi.org/10.17116/oftalma202614203163

Подписка 2026 Вестник офтальмологии (Russian Annals of Ophthalmology)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

This literature review analyzes the prospects for the use of depot drug formulations in dacryology. The limited bioavailability of conventional topical agents and the inability to maintain a stable drug concentration on the ocular surface stimulate the development of local controlled-release systems. Punctal plugs and intracanalicular implants, which use hydrogels and biodegradable polymers for prolonged delivery of anti-inflammatory and immunosuppressive drugs, have been studied extensively. Experimental designs include customizable drug-delivery constructs based on photopolymerizable and composite materials, expanding the possibilities of targeted therapy. Despite the obtained results, the potential of depot systems in the treatment of lacrimal drainage system diseases, including dacryostenosis, requires further investigation in clinical studies.

Keywords:

depot drug delivery systems
lacrimal pathways
punctal plugs
intracanalicular inserts
hydrogel-based systems
biodegradable implants
sustained drug release
dacryostenosis

Authors:

Yartsev V.D.

Krasnov Research Institute of Eye Diseases, Moscow, Russia

Atkova E.L.

Krasnov Research Institute of Eye Diseases, Moscow, Russia

Efremenko M.A.

Krasnov Research Institute of Eye Diseases, Moscow, Russia

Received:

03.12.2025

Accepted:

13.02.2026

Close metadata

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