Effectiveness of transpupillary thermotherapy in addition to combination chemotherapy for retinoblastoma

Saakyan S.V.; Tatskov R.A.; Myakoshina E.B.; Tsygankov A.Yu.; Ushakova T.L.

doi:https://doi.org/10.17116/oftalma202514103113

Saakyan S.V.

Helmholtz National Medical Research Center of Eye Diseases;
Russian University of Medicine

ORCID: 0000-0001-8591-428X

Tatskov R.A.

Helmholtz National Medical Research Center of Eye Diseases

ORCID: 0000-0001-5286-0051

Myakoshina E.B.

Helmholtz National Medical Research Center of Eye Diseases;
Russian University of Medicine

ORCID: 0000-0002-2087-7155

Tsygankov A.Yu.

Helmholtz National Medical Research Center of Eye Diseases;
Russian University of Medicine

ORCID: 0000-0001-9475-3545

Ushakova T.L.

Research Institute of Pediatric Oncology and Hematology named after Academician of RAMS L.A. Durnov of the National Medical Research Center of Oncology named after N.N. Blokhin

ORCID: 0000-0002-1933-8277

Effectiveness of transpupillary thermotherapy in addition to combination chemotherapy for retinoblastoma

Authors:

Saakyan S.V., Tatskov R.A., Myakoshina E.B., Tsygankov A.Yu., Ushakova T.L.

More about the authors

Journal: Russian Annals of Ophthalmology. 2025;141(3): 13‑19

DOI: 10.17116/oftalma202514103113

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To cite this article:

Saakyan SV, Tatskov RA, Myakoshina EB, Tsygankov AYu, Ushakova TL. Effectiveness of transpupillary thermotherapy in addition to combination chemotherapy for retinoblastoma. Russian Annals of Ophthalmology. 2025;141(3):13‑19. (In Russ.)
https://doi.org/10.17116/oftalma202514103113

Подписка 2026 Вестник офтальмологии (Russian Annals of Ophthalmology)

Использование инфографики авторами научных работ

PURPOSE

This study analyzed the outcomes of using TTT as an addition to combination chemotherapy in children with small RBs.

MATERIAL AND METHODS

The study included 42 patients (144 tumor foci) with small RBs treated between 2015 and 2020 using TTT and combination chemotherapy (systemic chemotherapy with local chemotherapy). Patients were aged 1 to 26 months (mean age 9.1±7.4 months). The mean follow-up period was 61.2±4.3 months.

RESULTS

Patients received 3—5 courses of systemic neoadjuvant polychemotherapy (NAPCT), superselective intra-arterial chemotherapy (SIAC), and intravitreal chemotherapy (IVC), which led to tumor size reduction. TTT was performed 3 to 16 months (mean 8.5±3.3 months) after initiation of chemotherapy. The number of coagulates in the treatment of resorbable tumors ranged from 5 to 16 (mean 10.5±3.5) and did not depend on the localization of small RBs. The diameter of coagulates ranged from 1000 to 2500 μm (mean 1600±600 μm). Addition of TTT to combination chemotherapy of small RBs resulted in partial tumor regression in 32.6% and complete tumor resorption in 68.1% of cases.

CONCLUSION

This study provides the first analysis of TTT outcomes in RB patients undergoing combined chemotherapy. TTT is a method of choice for the treatment of small RBs with height of ≤3.0 mm and any localization.

Keywords:

retinoblastoma

transpupillary thermotherapy

selective intra-arterial chemotherapy

neoadjuvant polychemotherapy

intravitreal chemotherapy

Authors:

Saakyan S.V.

Helmholtz National Medical Research Center of Eye Diseases;
Russian University of Medicine

ORCID: 0000-0001-8591-428X

Tatskov R.A.

Helmholtz National Medical Research Center of Eye Diseases

ORCID: 0000-0001-5286-0051

Myakoshina E.B.

Helmholtz National Medical Research Center of Eye Diseases;
Russian University of Medicine

ORCID: 0000-0002-2087-7155

Tsygankov A.Yu.

Helmholtz National Medical Research Center of Eye Diseases;
Russian University of Medicine

ORCID: 0000-0001-9475-3545

Ushakova T.L.

Research Institute of Pediatric Oncology and Hematology named after Academician of RAMS L.A. Durnov of the National Medical Research Center of Oncology named after N.N. Blokhin

ORCID: 0000-0002-1933-8277

Received:

11.05.2024

Accepted:

26.06.2024

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References:

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