Тяжелые металлы и нарушения углеводного обмена при заболеваниях органа зрения: систематический обзор

Закрыть метаданные

ЦЕЛЬ ИССЛЕДОВАНИЯ

Выявить негативное влияние тяжелых металлов на углеводный обмен, механизмы и предрасполагающие факторы, а также оценить их роль в этиопатогенезе, патофизиологии и прогрессировании заболеваний органа зрения.

МАТЕРИАЛЫ И МЕТОДЫ

В соответствии с рекомендациями по подготовке и представлению систематических обзоров PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) был проведен поиск в ряде баз данных (Scopus, PubMed и др.), собрана информация о связи и влиянии тяжелых металлов на углеводный обмен и патогенез заболеваний глаз. Включенные исследования оценивались по критериям качества программы развития навыков проведения критической оценки (Critical Appraisal Skills Programme), извлеченные данные анализировались методом нарративного синтеза.

РЕЗУЛЬТАТЫ

Из 128 найденных публикаций 24 соответствовали критериям включения. Тяжелые металлы ассоциированы с развитием и прогрессированием диабета и офтальмопатий, возникающих на его фоне (возрастная макулярная дегенерация, катаракта и диабетическая ретинопатия (ДР)), главным образом за счет токсического воздействия (индукцию, ингибирование и/или инактивацию) ферментов углеводного обмена и оксидативного стресса. Этиология ДР сложна и включает одновременное нарушение нескольких метаболических и сигнальных механизмов в нейроваскулярной единице сетчатки. Высокое сродство тяжелых металлов к меланину пигментного эпителия сетчатки делает ее особенно уязвимой к металл-индуцированной токсичности.

ЗАКЛЮЧЕНИЕ

В исследовании отмечены вредные эффекты хронического и периодического воздействия тяжелых металлов и отсутствие безопасного уровня экспозиции. Для профилактики офтальмопатий, возникающих вследствие металл-индуцированных нарушений углеводного обмена, среди групп риска целесообразно использовать металлохелаты, низкогликемические диеты, а также прибегать к изменениям образа жизни.

Ключевые слова:

углеводный обмен

гипергликемия индуцированная тяжелыми металлами

офтальмопатии при диабете

диабетическая катаракта

инсулинорезистентность индуцированная тяжелыми металлами

Авторы:

Удом Г.Дж.

Международный университет Кампалы;
Федеральный университет Ойе-Экити

ORCID: 0000-0003-3724-5944

Оритсемуелеби Б.

Государственный университет Дельты

ORCID: 0009-0004-2648-4805

Фраззоли Ч.

Высший институт здравоохранения

ORCID: 0000-0001-6802-2861

Бокка Б.

Высший институт здравоохранения

ORCID: 0000-0002-6503-6026

Руджиери Ф.

Высший институт здравоохранения

ORCID: 0000-0002-5161-8615

Орисакве О.Э.

Африканский центр передового опыта в области общественного здравоохранения и токсикологических исследований (ACE-PUTOR) — Университет Порт-Харкорта;
Центр передовых исследований, Европейский университет Лефке

ORCID: 0000-0002-5806-9858

Дата поступления:

21.11.2024

Дата принятия в печать:

12.12.2024

Список литературы:

Phani PRC, Prasad KR. Groundwater Contamination in Parts of North-western Hyderabad: a Hydrogeochemical and Geospatial Approach. In: Thambidurai P, Dikshit AK ed(s). Impacts of Urbanization on Hydrological Systems in India. Cham: Springer Int Publishing. 2023:293-312. https://doi.org/10.1007/978-3-031-21618-3_15
Sabir S, Akash MSH, Fiayyaz F, Saleem U, Mehmood MH, Rehman K. Role of cadmium and Arsenic as Endocrine Disruptors in the Metabolism of Carbohydrates: Inserting the Association into Perspectives. Biomed Pharmacother. 2019;114:108802. https://doi.org/10.1016/j.biopha.2019.108802
Kalra S, Unnikrishnan AG, Baruah MP, Sahay R, Bantwal G. Metabolic and Energy Imbalance in Dysglycemia-based Chronic Disease. Diabetes Metab Syndr Obes. 2021;14:165-184. https://doi.org/10.2147/DMSO.S286888
Stapleton F, Abad JC, Barabino S, Burnett A, et al. TFOS Lifestyle: Impact of Societal Challenges on the Ocular Surface. Ocul Surf. 2023;28:165-199. https://doi.org/10.1016/j.jtos.2023.04.006
Gulcin İ. Antioxidants and Antioxidant Methods: An Updated Overview. Arch Toxicol. 2020;94(3):651-715. https://doi.org/10.1007/s00204-020-02689-3
Pereira AR, Braga DF, Vassal M, Gomes IB, Simões M. Ultraviolet C Irradiation: A Promising Approach for the Disinfection of Public Spaces? Sci Total Environ. 2023;879:163007. https://doi.org/10.1016/j.scitotenv.2023.163007
Yeo M, Moawad H, Grunewald S. Disorders of Carbohydrate Metabolism: A Review of Glycogen Storage Disorders. Paediatr Child Health. 2023; 33(3):65-72. https://doi.org/10.1016/j.paed.2022.12.007
Joshua CJ. Metabolomics: A Microbial Physiology and Metabolism Perspective. Methods Mol Biol. 2019;1859:71-94. https://doi.org/10.1007/978-1-4939-8757-3_3
Gurel Z, Sheibani N. Potential of Carbonic Anhydrase Inhibitors in the Treatment of Oxidative Stress and Diabetes. In: Chegwidden WR, Carter ND ed(s). The Carbonic Anhydrases: Current and Emerging Therapeutic Targets. Cham: Springer Int Publishing. 2021:121-146. https://doi.org/10.1007/978-3-030-79511-5_6
Irshad K, Rehman K, Fiayyaz F, et al. Role of Heavy Metals in Metabolic Disorders. In: Akash, M.S.H., Rehman, K., Hashmi, M.Z. ed(s). Endocrine Disrupting Chemicals-induced Metabolic Disorders and Treatment Strategies. Emerging Contaminants and Associated Treatment Technologies. Cham: Springer. 2021:203-219. https://doi.org/10.1007/978-3-030-45923-9_13
Liton PB, Boesze-Battaglia K, Boulton ME, et al. Autophagy in the Eye: From Physiology to Pathophysiology. Autophagy Rep. 2023;2(1):2178996. https://doi.org/10.1080/27694127.2023.2178996
Van Leemputte F, Vanthienen W, Wijnants S, Van Zeebroeck G, Thevelein JM. Aberrant Intracellular pH Regulation Limiting Glyceraldehyde-3-Phosphate Dehydrogenase Activity in the Glucose-Sensitive Yeast tps1Δ Mutant. mBio. 2020 27;11(5):e02199-20. https://doi.org/10.1128/mBio.02199-20
Moher D, Liberati A, Tetzlaff J, Altman DG; PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Int J Surg. 2010;8(5):336-341. https://doi.org/10.1016/j.ijsu.2010.02.007
O’Dea RE, Lagisz M, Jennions MD, et al. Preferred Reporting Items for Systematic Reviews and Meta-Analyses in Ecology and Evolutionary Biology: A PRISMA Extension. Biol Rev Camb Philos Soc. 2021;96(5):1695-1722. https://doi.org/10.1111/brv.12721
Page MJ, Moher D, Bossuyt PM, et al. PRISMA 2020 Explanation and Elaboration: Updated Guidance and Exemplars for Reporting Systematic Reviews. BMJ. 2021;372:160. https://doi.org/10.1136/bmj.n160
Long HA, French DP, Brooks JM. Optimising the Value of the Critical Appraisal Skills Programme (CASP) Tool for Quality Appraisal in Qualitative Evidence Synthesis. Res Methods Med Health Sci. 2020;1(1):31-42. https://doi.org/10.1177/2632084320947559
Cai J, Li Y, Liu S, et al. Associations Between Multiple Heavy Metals Exposure and Glycated Haemoglobin in a Chinese population. Chemosphere. 2022;287:132159. https://doi.org/10.1016/j.chemosphere.2021.132159
Erie JC, Butz JA, Good JA, Erie EA, Burritt MF, Cameron JD. Heavy Metal Concentrations in Human Eyes. Am J Ophthalmol. 2005;139(5):888-893. https://doi.org/10.1016/j.ajo.2004.12.007
Francisco SG, Smith KM, Aragonès G, et al. Dietary Patterns, Carbohydrates, and Age-related Eye Diseases. Nutr. 2020;12(9):2862. https://doi.org/10.3390/nu12092862
Harun AR, Setiawan B, Komari N. Interactions of Heavy Metals on Enzymes in Carbohydrate Metabolism: In silico Study on Glucokinase and Pyruvate Kinase. Mutiara Medika: Jurnal Kedokteran dan Kesehatan. 2022;22(2):124-128. https://doi.org/10.18196/mmjkk.v22i2.14904
Javaid A, Akbar I, Javed H, et al. Role of Heavy Metals in Diabetes: Mechanisms and Treatment Strategies. Crit Rev Eukaryot Gene Expr. 2021;31(3). https://doi.org/10.1615/CritRevEukaryotGeneExpr.2021037971
Ji JH, Jin MH, Kang JH, et al. Relationship Between Heavy Metal Exposure and Type 2 Diabetes: A Large-scale Retrospective Cohort Study Using Occupational Health Examinations. BMJ Open. 2021;11(3):e039541. https://doi.org/10.1136/bmjopen-2020-039541
Liou YH, Chen YJ, Chen WL, et al. Associations between Biomarkers of Metal Exposure and Dry Eye Metrics in Shipyard Welders: A Cross-sectional Study. Int J Environ Res Public Health. 2022;19(4):2264. https://doi.org/10.3390/ijerph19042264
Lutty GA. Effects of Diabetes on the Eye. Investig Ophthalmol Vis Sci. 2013;54(14):ORSF81-ORSF87. https://doi.org/10.1167/iovs.13-12979
Mamtani R, Stern P, Dawood I, Cheema S. Metals and Disease: A Global Primary Health Care Perspective. J Toxicol. 2011;319136. https://doi.org/10.1155/2011/319136
Miteu GD. Glucose Metabolism and Cataract: Prevention and Treatment — A Review. World Sci News. 2021;161:11-27.
Pollreisz A, Schmidt-Erfurth U. Diabetic Cataract—Pathogenesis, Epidemiology and Treatment. J Ophthalmol. 2010;608751. https://doi.org/10.1155/2010/608751
Poll-The, BT, Wenniger-Prick, CM. The Eye in Metabolic Diseases: Clues to Diagnosis. Eur J Paediatr Neurol. 2011;15(3):197-204. https://doi.org/10.1016/j.ejpn.2011.03.005
Saba S, Akash MSH, Rehman K, Saleem U, Fiayyaz F., Ahmad T. Assessment of Heavy Metals by ICP‐OES and their Impact on Insulin Stimulating Hormone and Carbohydrate Metabolizing Enzymes. Clin Exp Pharmacol Physiol. 2020;47(10):1682-1691. https://doi.org/10.1111/1440-1681.13353
Santos MJ, Mohammad G, Zhong QA, Kowluru R. Diabetic Retinopathy, Superoxide Damage and Antioxidants. Curr Pharm Biotechnol. 2011;12(3):352-361. https://doi.org/10.2174/138920111794480507
Strydom C, Robinson C, Pretorius E, Whitcutt JM, Marx J, Bornman MS. The Effect of Selected Metals on the Central Metabolic Pathways in Biology: A Review. Water Sa. 2006;32(4):543-554. https://doi.org/10.4314/wsa.v32i4.5155
Wang Y, Zhang P, Chen X, et al. Multiple Metal Concentrations and Gestational Diabetes Mellitus in Taiyuan, China. Chemosphere. 2019;237:124412. https://doi.org/10.1016/j.chemosphere.2019.124412
Witkowska D, Słowik J, Chilicka K. Heavy Metals and Human Health: Possible Exposure Pathways and The Competition for Protein Binding Sites. Molecules. 2021;26(19):6060. https://doi.org/10.1016/j.chemosphere.2019.124412
Yang A, Liu S, Cheng Z, et al. Dose-response Analysis of Environmental Exposure to Multiple Metals and their Joint Effects with Fasting Plasma Glucose Among Occupational Workers. Chemosphere. 2017;186;314-321. https://doi.org/10.1016/j.chemosphere.2017.08.002
Yuan Y, Xiao Y, Yu Y, et al. Associations of Multiple Plasma Metals with Incident Type 2 Diabetes in Chinese Adults: The Dongfeng-Tongji Cohort. Environ Pollut. 2018;237:917-925. https://doi.org/10.1016/j.envpol.2018.01.046
Zhao D, Cho J, Kim MH, Friedman D, Guallar E. Diabetes, Glucose Metabolism, and Glaucoma: the 2005-2008 National Health and Nutrition Examination Survey. PloS One. 2014;9(11):e112460. https://doi.org/10.1371/journal.pone.0112460
Rowan S, Jiang S, Korem T, et al. Involvement of a Gut–retina Axis in Protection Against Dietary Glycemia-induced Age-related Macular Degeneration. Proc Natl Acad Sci. 2017;114(22):E4472-E4481. https://doi.org/10.1073/pnas.1702302114
Trouiller-Gerfaux P, Podglajen E, Hulo S, et al. The Association Between Blood Cadmium and Glycated Haemoglobin Among Never-, Former, and Current Smokers: A Cross-Sectional Study in France. Environ Res. 2019; 178:108673.
Miller DJ, Cascio MA, Rosca MG. Diabetic Retinopathy: The Role of Mitochondria in the Neural Retina and Microvascular Disease. Antioxidants. 2020;9(10):905. https://doi.org/10.3390/antiox9100905
Chang CW, Wang CW, Wu DW, et al. Significant Association Between Blood Lead (Pb) Level and Haemoglobin A1c in Non-diabetic Population. Diabet Metab. 2021;47:101233.
Bertels LK, Fernández Murillo L, Heinisch JJ. The Pentose Phosphate Pathway In Yeasts–More Than a Poor Cousin of Glycolysis. Biomolecules. 2021;11(5):725. https://doi.org/10.3390/biom11050725
Bueno E, Pinedo V, Shinde DD, et al. Transient Glycolytic Complexation of Arsenate Enhances Resistance in the Enteropathogen Vibrio cholerae. Mbio. 2022;13(5):e01654-22. https://doi.org/10.1128/mbio.01654-22
Yang J, Yang A, Cheng N, et al. Sex-specific Associations of Blood and Urinary Manganese Levels With Glucose Levels, Insulin Resistance and Kidney Function in US Adults: National Health and Nutrition Examination Survey 2011-2016. Chemosphere 2020;258:126940.
Guymer C, Wood JP, Chidlow G, Casson RJ. Neuroprotection in Glaucoma: Recent Advances and Clinical Translation. Clin Exp Ophthalmol. 2019;47(1):88-105. https://doi.org/10.1111/ceo.13336
Evans JL, Goldfine ID, Maddux BA, Grodsky GM. Are Oxidative Stress-activated Signaling Pathways Mediators of Insulin Resistance and β-cell Dysfunction? Diabetes. 2003;52(1):1-8. https://doi.org/10.1016/j.ajo.2004.12.007
Bede-Ojimadu O, Orish CN, Bocca B, Ruggieri F, Frazzoli C, Orisakwe OE. Trace Elements Exposure and Risk in Age-Related Eye Diseases: A Systematic Review of Epidemiological Evidence. J Environ Sci Health, Part C-Environ Carcinogenesis Ecotoxicol Rev. 2021;39(3):293-339. https://doi.org/10.1080/26896583.2021.1916331
Chiu CJ, Milton RC, Klein R, Gensler G, Taylor A. Dietary Compound Score and Risk of Age-related Macular Degeneration in the Age-related Eye Disease Study. Ophthalmol. 2009:116(5):939-946. https://doi.org/10.1016/j.ophtha.2008.12.025
Sin HP, Liu DT, Lam DS. Lifestyle Modification, Nutritional and Vitamins Supplements for Age‐related Macular Degeneration. Acta Ophthalmologica. 2013;91(1):6-11. https://doi.org/10.1111/j.1755-3768.2011.02357.x
Farhangi MA, Vajdi M. The Association Between Dietary Inflammatory Index and Risk of Central Obesity in Adults: An Updated Systematic Review and Meta-analysis. Int J Vitamin Nutr Res. 2020;90:5-6. https://doi.org/10.1024/0300-9831/a000648
Moghaddam EAM, Motarjemizadeh G, Ayremlou P, Zarrin R. Major Dietary Patterns In Relation to Age-related Cataract. Clin Nutr. (ESPEN) 2021;41:325-330.
Sedaghat F, Ghanavati M, Hajian PN, Hajishirazi S, Ehteshami M, Rashidkhani B. Nutrient Patterns and Risk of Cataract: A Case-Control Study. Int J Ophthalmol. 2017;10(4):586.
Keenan TDL, Cukras CA, Chew EY. Age-related Macular Degeneration: Epidemiology and Clinical Aspects. Adv Exp Med Biol. 2021;1256:1-31. https://doi.org/10.1007/978-3-030-66014-7_1
Rehman K, Fatima F, Waheed I, Akash MSH. Prevalence of Exposure of Heavy Metals and Their Impact on Health Consequences. J. Cell. Biochem. 2018;119:157-184.
Moon SS. Association of Lead, Mercury and Cadmium with Diabetes in the Korean Population: The Korea National Health and Nutrition Examination Survey (KNHANES) 2009-2010. Diabet Med. 2013;30:e143-148.
Hughes MF, Beck BD, Chen Y, Lewis AS, Thomas DJ. Arsenic Exposure and Toxicology: A Historical Perspective. Toxicol Sci. 2011;123:305-332.
Chen YW, Yang CY, Huang CF, Hung DZ, Leung YM, Liu SH. Heavy Metals, Islet Function and Diabetes Development. Islets. 2009;1:169-176.
Galhardi CM, Diniz YS, Faine LA, et al. Toxicity of Copper Intake: Lipid Profile, Oxidative Stress and Susceptibility to Renal Dysfunction. Food Chem Toxicol. 2004;42:2053-2060.
Maiese K, Chong ZZ, Shang YC. Mechanistic Insights into Diabetes Mellitus and Oxidative Stress. Curr Med Chem. 2007;14:1729-1738.
Lee SH, Kang EM, Kim GA, et al. Three Toxic Heavy Metals in Open-Angle Glaucoma with Low-Teen and High-Teen Intraocular Pressure: A Cross-Sectional Study from South Korea. PLoS One. 2016;11(10):e0164983. https://doi.org/10.1371/journal.pone.0164983

Закрыть метаданные