Методы хирургической реконструкции конъюнктивы

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Реконструкция конъюнктивы играет ключевую роль в регенерации глазной поверхности при ее поражении и является неотъемлемой частью этого процесса. Травмы, химические, термические ожоги и множественные хирургические вмешательства могут серьезно нарушать целостность конъюнктивальной ткани и приводить к росту фиброзной ткани, рубцеванию сводов, их укорочению, а также другим осложнениям в виде трихиаза, эрозий и язв роговицы. При поражении обширной зоны конъюнктивы донорской ткани для замещения дефекта может быть недостаточно, и в таких случаях требуется применение больших по площади трансплантатов. Современные модификации хирургических методик и развивающаяся область тканевой инженерии, а также достижения в сфере исследования стволовых клеток предлагают многообещающие новые альтернативы для решения такого рода задач. В данном обзоре рассматриваются существующие на сегодняшний день хирургические методы реконструкции конъюнктивы.

Ключевые слова:

конъюнктива

реконструкция конъюнктивы

тканевая инженерия

аутотрансплантация

амниотическая мембрана

биополимеры

Авторы:

Криволапова Д.А.

ФГБНУ «Научно-исследовательский институт глазных болезней им. М.М. Краснова»

ORCID: 0000-0001-6974-7872

Андреев А.Ю.

ФГБНУ «Научно-исследовательский институт глазных болезней им. М.М. Краснова»

ORCID: 0000-0002-0267-9040

Осидак Е.О.

ФГБУ «Национальный медицинский исследовательский центр детской гематологии, онкологии и иммунологии им. Д. Рогачева» Минздрава России

ORCID: 0000-0003-2549-4011

Будникова Е.А.

ФГБНУ «Научно-исследовательский институт глазных болезней им. М.М. Краснова»

ORCID: 0000-0001-7721-7652

Дата поступления:

31.03.2023

Дата принятия в печать:

19.07.2023

Список литературы:

Paulsen F. Functional anatomy and immunological interactions of ocular surface and adnexa. Dev Ophthalmol. 2008;41:21-35. https://doi.org/10.1159/000131068
Hatton MP, Rubin PA. Conjunctival regeneration. Adv Biochem Eng Biotechnol. 2005;94:125-40. https://doi.org/10.1007/b100002
Chan F, Benson MD, Plemel DJA, Mahmood MN, Chan SM. A diagnosis of Stevens-Johnson Syndrome (SJS) in a patient presenting with superficial keratitis. Am J Ophthalmol Case Rep. 2018;11:167-169. https://doi.org/10.1016/j.ajoc.2018.06.004
Makuloluwa AK, Hamill KJ, Rauz S, et al. Biological tissues and components, and synthetic substrates for conjunctival cell transplantation. Ocul Surf. 2021;22:15-26. https://doi.org/10.1016/j.jtos.2021.06.003
Schrader S, Notara M, Beaconsfield M, Tuft SJ, Daniels JT, Geerling G. Tissue engineering for conjunctival reconstruction: established methods and future outlooks. Curr Eye Res. 2009;34(11):913-924. https://doi.org/10.3109/02713680903198045
Zhou H, Lu Q, Guo Q, Chae J, Fan X, Elisseeff JH, Grant MP. Vitrified collagen-based conjunctival equivalent for ocular surface reconstruction. Biomaterials. 2014;35(26):7398-7406. https://doi.org/10.1016/j.biomaterials.2014.05.024
Lu Q, Al-Sheikh O, Elisseeff JH, Grant MP. Biomaterials and Tissue Engineering Strategies for Conjunctival Reconstruction and Dry Eye Treatment. Middle East Afr J Ophthalmol. 2015;22(4):428-434. https://doi.org/10.4103/0974-9233.167818
Chen LB, Zhang SY, Yan CX, Yao QK, Shao CY, Fu Y. Evaluation of chronic ocular sequelae in patients with symblepharon caused by ocular burns. Int J Ophthalmol. 2020;13(7):1066-1073. https://doi.org/10.18240/ijo.2020.07.08
Feng J, Liu Y, Ren Y, Shi W, Kang H, Tan Y, Wu R, Zhang G, He Y. Evaluation of Dry Eye Severity and Ocular Surface Inflammation in Patients with Pemphigus and Pemphigoid. Ocul Immunol Inflamm. 2023:1-9. https://doi.org/10.1080/09273948.2022.2154680
Wang T, Shan F, Zhou Q, Shi W, Xie L. Allogeneic Cultivated Limbal Epithelial Sheet Transplantation in Reconstruction of Conjunctival Sac After Chemical and Thermal Burns. Front Med (Lausanne). 2021;8:697264. https://doi.org/10.3389/fmed.2021.697264
Barraquer J. Corneal autografting. In: King JH, McTigue JW. The Cornea World Congress. Washington, Butterworth; 1965;627.
Kenyon KR, Wagoner MD, Hettinger ME. Conjunctival autograft transplantation for advanced and recurrent pterygium. Ophthalmology. 1985;92(11): 1461-1470. https://doi.org/10.1016/s0161-6420(85)33831-9
Fonseca EC, Rocha EM, Arruda GV. Comparison among adjuvant treatments for primary pterygium: a network meta-analysis. Br J Ophthalmol. 2018;102(6):748-756. https://doi.org/10.1136/bjophthalmol-2017-310288
Hosni FA. Repair of trachomatous cicatricial entropion using mucous membrane graft. Arch Ophthalmol. 1974;91(1):49-51. https://doi.org/10.1001/archopht.1974.03900060053013
Mai C, Bertelmann E. Oral mucosal grafts: old technique in new light. Ophthalmic Res. 2013;50(2):91-98. https://doi.org/10.1159/000351631
Murube J. Labial salivary gland transplantation in severe dry eye. Oculoplast Orbital Reconstr Surg. 1998;1:104-110.
Гущина М.Б., Терещенко А.В., Гущин А.В., Афанасьева Д.С. Замещение дефектов конъюнктивы: возможности и ограничения. Клиническая офтальмология. 2022;22(2):137-144. https://doi.org/10.32364/2311-7729-2022-22-2-137-144
Kuckelkorn R, Schrage N, Redbrake C, Kottek A, Reim M. Autologous transplantation of nasal mucosa after severe chemical and thermal eye burns. Acta Ophthalmol Scand. 1996;74(5):442-448. https://doi.org/10.1111/j.1600-0420.1996.tb00596.x
Wenkel H, Rummelt V, Naumann GO. Long term results after autologous nasal mucosal transplantation in severe mucus deficiency syndromes. Br J Ophthalmol. 2000;84(3):279-284. https://doi.org/10.1136/bjo.84.3.279
Kim JC, Tseng SC. Transplantation of preserved human amniotic membrane for surface reconstruction in severely damaged rabbit corneas. Cornea. 1995; 14(5):473-484.
Jie J, Yang J, He H, et al. Tissue remodeling after ocular surface reconstruction with denuded amniotic membrane. Sci Rep. 2018;8(1):6400. Published 2018 Apr 23. https://doi.org/10.1038/s41598-018-24694-4
Riau AK, Beuerman RW, Lim LS, Mehta JS. Preservation, sterilization and de-epithelialization of human amniotic membrane for use in ocular surface reconstruction. Biomaterials. 2010;31(2):216-225. https://doi.org/10.1016/j.biomaterials.2009.09.034
Meller D, Pauklin M, Thomasen H, Westekemper H, Steuhl KP. Amniotic membrane transplantation in the human eye. Dtsch Arztebl Int. 2011;108(14): 243-248. https://doi.org/10.3238/arztebl.2011.0243
Palamar M, Yaman B, Akalın T, Yağcı A. Amniotic Membrane Transplantation in Surgical Treatment of Conjunctival Melanoma: Long-term Results. Turk J Ophthalmol. 2018;48(1):15-18. https://doi.org/10.4274/tjo.62681
Dua HS, Maharajan VS, Hopkinson A. Controversies and Limitations of Amniotic Membrane in Ophthalmic Surgery. In: Reinhard T, Larkin D (eds). Cornea and External Eye Disease. Essentials in Ophthalmology. Berlin, Heidelberg: Springer; 2006;21-33. https://doi.org/10.1007/3-540-31226-9_2
Clearfield E, Hawkins BS, Kuo IC. Conjunctival Autograft Versus Amniotic Membrane Transplantation for Treatment of Pterygium: Findings From a Cochrane Systematic Review. Am J Ophthalmol. 2017;182:8-17. https://doi.org/10.1016/j.ajo.2017.07.004
Barabino S, Rolando M, Bentivoglio G, et al. Role of amniotic membrane transplantation for conjunctival reconstruction in ocular-cicatricial pemphigoid. Ophthalmology. 2003;110(3):474-480. https://doi.org/10.1016/S0161-6420(02)01892-4
Prabhasawat P, Tseng SC. Impression cytology study of epithelial phenotype of ocular surface reconstructed by preserved human amniotic membrane. Arch Ophthalmol. 1997;115(11):1360-1367. https://doi.org/10.1001/archopht.1997.01100160530001
Meller D, Dabul V, Tseng SC. Expansion of conjunctival epithelial progenitor cells on amniotic membrane. Exp Eye Res. 2002;74(4):537-545. https://doi.org/10.1006/exer.2001.1163
Drechsler CC, Kunze A, Kureshi A, Grobe G, Reichl S, Geerling G, Daniels JT, Schrader S. Development of a conjunctival tissue substitute on the basis of plastic compressed collagen. J Tissue Eng Regen Med. 2017;11(3): 896-904. https://doi.org/10.1002/term.1991
Martínez-Osorio H, Calonge M, Corell A, et al. Characterization and short-term culture of cells recovered from human conjunctival epithelium by minimally invasive means. Mol Vis. 2009;15:2185-2195.
Inatomi T, Nakamura T, Kojyo M, Koizumi N, Sotozono C, Kinoshita S. Ocular surface reconstruction with combination of cultivated autologous oral mucosal epithelial transplantation and penetrating keratoplasty. Am J Ophthalmol. 2006;142(5):757-764. https://doi.org/10.1016/j.ajo.2006.06.004
Prabhasawat P, Ekpo P, Uiprasertkul M, et al. Long-term result of autologous cultivated oral mucosal epithelial transplantation for severe ocular surface disease. Cell Tissue Bank. 2016;17(3):491-503. https://doi.org/10.1007/s10561-016-9575-4
Badylak SF. The extracellular matrix as a scaffold for tissue reconstruction. Semin Cell Dev Biol. 2002;13(5):377-383. https://doi.org/10.1016/s1084952102000940
Srimurugan B, Nainar M, Ramanan S, Ramesh B, Cherian KM. Use of Indigenous Decellularized Valved Xenograft Conduit for Double-Barrel Right Ventricular Outflow Tract Reconstruction: Nine-Year Follow-Up. World J Pediatr Congenit Heart Surg. 2016;7(4):520-522. https://doi.org/10.1177/2150135115613745
Raya-Rivera A, Esquiliano DR, Yoo JJ, Lopez-Bayghen E, Soker S, Atala A. Tissue-engineered autologous urethras for patients who need reconstruction: an observational study. Lancet. 2011;377(9772):1175-1182. https://doi.org/10.1016/S0140-6736(10)62354-9
Hoshiba T, Lu H, Kawazoe N, Chen G. Decellularized matrices for tissue engineering. Expert Opin Biol Ther. 2010;10(12):1717-1728. https://doi.org/10.1517/14712598.2010.534079
Dhandayuthapani B, Yoshida Y, Maekawa T, Kumar DS. Polymeric scaffolds in tissue engineering application: a review. Int J Polymer Sci. 2011;2011:1-19. https://doi.org/10.1155/2011/290602
Witt J, Mertsch S, Borrelli M, et al. Decellularised conjunctiva for ocular surface reconstruction. Acta Biomater. 2018;67:259-269. https://doi.org/10.1016/j.actbio.2017.11.054
Zhao L, Jia Y, Zhao C, et al. Ocular surface repair using decellularized porcine conjunctiva. Acta Biomater. 2020;101:344-356. https://doi.org/10.1016/j.actbio.2019.11.006
Stankus JJ, Freytes DO, Badylak SF, Wagner WR. Hybrid nanofibrous scaffolds from electrospinning of a synthetic biodegradable elastomer and urinary bladder matrix. J Biomater Sci Polym Ed. 2008;19(5):635-652. https://doi.org/10.1163/156856208784089599
Bosworth LA, Doherty KG, Hsuan JD, Cray SP, D’Sa RA, Pineda Molina C, Badylak SF, Williams RL. Material Characterisation and Stratification of Conjunctival Epithelial Cells on Electrospun Poly(ε-Caprolactone) Fibres Loaded with Decellularised Tissue Matrices. Pharmaceutics. 2021; 13(3):318. https://doi.org/10.3390/pharmaceutics13030318
Borrelli M, Joepen N, Reichl S, et al. Keratin films for ocular surface reconstruction: evaluation of biocompatibility in an in-vivo model. Biomaterials. 2015;42:112-120. https://doi.org/10.1016/j.biomaterials.2014.11.038
Pritchard EM, Dennis PB, Omenetto F, Naik RR, Kaplan DL. Review physical and chemical aspects of stabilization of compounds in silk. Biopolymers. 2012;97(6):479-498. https://doi.org/10.1002/bip.22026
He M, Storr-Paulsen T, Wang AL, et al. Artificial Polymeric Scaffolds as Extracellular Matrix Substitutes for Autologous Conjunctival Goblet Cell Expansion. Invest Ophthalmol Vis Sci. 2016;57(14):6134-6146. https://doi.org/10.1167/iovs.16-20081
Long K, Liu Y, Li W, et al. Improving the mechanical properties of collagen-based membranes using silk fibroin for corneal tissue engineering. J Biomed Mater Res A. 2015;103(3):1159-1168. https://doi.org/10.1002/jbm.a.35268
Tsai RJ, Tseng SC. Substrate modulation of cultured rabbit conjunctival epithelial cell differentiation and morphology. Invest Ophthalmol Vis Sci. 1988; 29(10):1565-1576.
Brown R, Wiseman M, Chuo CB, Cheema U, Nazhat S. Ultrarapid Engineering of Biomimetic Materials and Tissues: Fabrication of Nano- and Microstructures by Plastic Compression. Adv Funct Mater 2005;15(11):1762-1770. https://doi.org/10.1002/adfm.200500042
Witt J, Borrelli M, Mertsch S, Geerling G, Spaniol K, Schrader S. Evaluation of Plastic-Compressed Collagen for Conjunctival Repair in a Rabbit Model. Tissue Eng Part A. 2019;25(15-16):1084-1095. https://doi.org/10.1089/ten.TEA.2018.0190
Takezawa T, Ozaki K, Nitani A, Takabayashi C, Shimo-Oka T. Collagen vitrigel: a novel scaffold that can facilitate a three-dimensional culture for reconstructing organoids. Cell Transplant. 2004;13(4):463-473. https://doi.org/10.3727/000000004783983882
Calderón-Colón X, Xia Z, Breidenich JL, et al. Structure and properties of collagen vitrigel membranes for ocular repair and regeneration applications. Biomaterials. 2012;33(33):8286-8295. https://doi.org/10.1016/j.biomaterials.2012.07.062
Sionkowska A. Current research on the blends of natural and synthetic polymers as new biomaterials: Review. Prog Polym Sci. 2011;36(9):1254-1276. https://doi.org/10.1016/j.progpolymsci.2011.05.003
Spaniol K, Holtmann C, Geerling G, Schrader S. Neue Ansätze zur Rekonstruktion der Augenoberfläche jenseits der Hornhaut [New approaches to ocular surface reconstruction beyond the cornea]. Ophthalmologe. 2017; 114(4):307-317. (In Germ.). https://doi.org/10.1007/s00347-016-0419-1
Elmowafy EM, Tiboni M, Soliman ME. Biocompatibility, biodegradation and biomedical applications of poly(lactic acid)/poly(lactic-co-glycolic acid) micro and nanoparticles. J Pharm Investig. 2019;49:347-380. https://doi.org/10.1007/s40005-019-00439-x
Hong S, Yun JH, Kim ES, Kim JS, Tchah H, Hwang C. Human Conjunctival Epithelial Sheets Grown on Poly(Lactic-Co-Glycolic) Acid Membranes and Cocultured With Human Tenon’s Fibroblasts for Corneal Repair. Invest Ophthalmol Vis Sci. 2018;59(3):1475-1485. https://doi.org/10.1167/iovs.17-22719
Ang LP, Cheng ZY, Beuerman RW, Teoh SH, Zhu X, Tan DT. The development of a serum-free derived bioengineered conjunctival epithelial equivalent using an ultrathin poly(epsilon-caprolactone) membrane substrate. Invest Ophthalmol Vis Sci. 2006;47(1):105-112. https://doi.org/10.1167/iovs.05-0512
Miller K, Hsu JE, Soslowsky LJ. Materials in Tendon and Ligament Repair. Comprehens Biomater. 2011;257-279. https://doi.org/10.1016/b978-0-08-055294-1.00218-x
Shin YJ, Lee HI, Kim MK, et al. Biocompatibility of nanocomposites used for artificial conjunctiva: in vivo experiments. Curr Eye Res. 2007;32(1):1-10. https://doi.org/10.1080/02713680601077061
Yao Q, Hu Y, Yu F, Zhang W, Fu Y. A novel application of electrospun silk fibroin/poly(l-lactic acid-co-ε-caprolactone) scaffolds for conjunctiva reconstruction. RSC Adv. 2018;8(33):18372-18380. https://doi.org/10.1039/c7ra13551c

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