Electroretinographic signs of retinal remodeling after experimental induction of retinal pigment epithelium atrophy

Neroev V.V.

Helmholtz National Medical Research Center of Eye Diseases;
A.I. Evdokimov Moscow State University of Medicine and Dentistry

Neroeva N.V.

Helmholtz National Medical Research Center of Eye Diseases

Zueva M.V.

Helmholtz National Medical Research Center of Eye Diseases

Katargina L.A.

Helmholtz National Medical Research Center of Eye Diseases

ORCID: 0000-0002-4857-0374

Tsapenko I.V.

Helmholtz National Medical Research Center of Eye Diseases

Ilyukhin P.A.

Helmholtz National Medical Research Center of Eye Diseases

Losanova O.A.

Helmholtz National Medical Research Center of Eye Diseases

Karmokova A.G.

Helmholtz National Medical Research Center of Eye Diseases

Rogov S.V.

Helmholtz National Medical Research Center of Eye Diseases

Electroretinographic signs of retinal remodeling after experimental induction of retinal pigment epithelium atrophy

Authors:

Neroev V.V., Neroeva N.V., Zueva M.V., Katargina L.A., Tsapenko I.V., Ilyukhin P.A., Losanova O.A., Karmokova A.G., Rogov S.V.

More about the authors

Journal: Russian Annals of Ophthalmology. 2021;137(4): 24‑30

DOI: 10.17116/oftalma202113704124

Downloaded: 27

To cite this article:

Neroev VV, Neroeva NV, Zueva MV, et al. . Electroretinographic signs of retinal remodeling after experimental induction of retinal pigment epithelium atrophy. Russian Annals of Ophthalmology. 2021;137(4):24‑30. (In Russ., In Engl.)
https://doi.org/10.17116/oftalma202113704124

Подписка 2025 (Russian Annals of Ophthalmology)

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PURPOSE

To determine the alterations in activity of the retina that characterize its remodeling in induction of RPE atrophy.

MATERIAL AND METHODS

Full-field electroretinograms (ERG), pattern ERG, and multifocal ERG were recorded according to the ISCEV standards from the right eyes of twenty rabbits of the New Zealand albino breed 6—7 weeks after induction of RPE atrophy by subretinal administration of 0.9% sodium chloride or bevacizumab solution.

RESULTS

Characteristic electroretinographic signs of RPE atrophy and retinal remodeling are described. Changes in ERG indicate a predominant inhibition of the functional activity of photoreceptors compared with bipolar cells, which objectively reflects an impairment of their metabolism associated with RPE pathology. With the injection of bevacizumab, a sharp weakening of the functional symbiosis of Mueller cells with bipolar cells was observed. According to pattern ERG, the function of the retinal ganglion cells was reduced. The reaction of the paired eyes after induction of RPE atrophy included a moderate decrease in the amplitude of b-wave of photopic ERG and activation of glia-neuronal relationships.

CONCLUSION

Subretinal injections of 0.9% sodium chloride and bevacizumab trigger changes in the retina that reflect specific remodeling of retinal neurons of the second and third orders, which characterizes the used models of RPE atrophy.

Keywords:

atrophy of retinal pigment epithelium

retinal remodeling

electroretinography

sodium chloride

bevacizumab

Authors:

Neroev V.V.

Helmholtz National Medical Research Center of Eye Diseases;
A.I. Evdokimov Moscow State University of Medicine and Dentistry

Neroeva N.V.

Helmholtz National Medical Research Center of Eye Diseases

Zueva M.V.

Helmholtz National Medical Research Center of Eye Diseases

Katargina L.A.

Helmholtz National Medical Research Center of Eye Diseases

ORCID: 0000-0002-4857-0374

Tsapenko I.V.

Helmholtz National Medical Research Center of Eye Diseases

Ilyukhin P.A.

Helmholtz National Medical Research Center of Eye Diseases

Losanova O.A.

Helmholtz National Medical Research Center of Eye Diseases

Karmokova A.G.

Helmholtz National Medical Research Center of Eye Diseases

Rogov S.V.

Helmholtz National Medical Research Center of Eye Diseases

Received:

14.07.2020

Accepted:

24.08.2020

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