The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-4329
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2026
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Kasparova E.A.

Krasnov Research Institute of Eye Diseases

Krasnolutskaya E.I.

Research Institute of Eye Diseases

Kruglova E.M.

Research Institute of Eye Diseases

Mooren’s ulcer

Authors:

Kasparova E.A., Krasnolutskaya E.I., Kruglova E.M.

More about the authors

Journal: Russian Annals of Ophthalmology. 2020;136(5): 241‑247

DOI: 10.17116/oftalma2020136052241

Read: 9267 times

Download PDF (RU)
Contact the author
Table of contents

MOOREN’S ULCER
MOOREN’S ULCER

To cite this article:

Kasparova EA, Krasnolutskaya EI, Kruglova EM. Mooren’s ulcer. Russian Annals of Ophthalmology. 2020;136(5):241‑247. (In Russ.)
https://doi.org/10.17116/oftalma2020136052241

Подписка 2026 Вестник офтальмологии (Russian Annals of Ophthalmology)
МСФ на ЯМ
Использование инфографики авторами научных работ
Close metadata
Recommended articles:
Uterus transplantation: achievements, challenges, and future perspectives. Russian Journal of Human Reproduction. 2025;(5):20-29
The opti­mization of patient mana­gement after otosurgical inte­rventions. Russian Bulletin of Otorhinolaryngology. 2025;(5):13-16
Abstract:

The article reviews available data on Mooren’s ulcer — a rare disease of, supposedly, autoimmune origin that manifests as peripheral ulceration of the cornea and poses a risk of its perforation. The variability of clinical presentation and course of the disease often leads to misdiagnosis and inadequate treatment. The present review focuses on specific signs characteristic of the disease and the most effective methods of its treatment.

Keywords:

Mooren’s ulcer
peripheral corneal ulcer
perforation
immunosuppression
corneal epithelium antibodies
corneoscleral graft

Authors:

Kasparova E.A.

Krasnov Research Institute of Eye Diseases

Krasnolutskaya E.I.

Research Institute of Eye Diseases

Kruglova E.M.

Research Institute of Eye Diseases

Received:

06.03.2020

Accepted:

08.04.2020

Close metadata

References:

  1. Jay GL. Chronic Serpiginous Ulcer of the Cornea (Mooren’s Ulcer)*. American Journal of Ophthalmology. 1949;32(5):691-698.  https://doi.org/10.1016/0002-9394(49)91423-3
  2. McKenzie H. Disease of the Eye. 1854;631. 
  3. Mooren A. Ulcus Rodens. Ophthalmiatrische Beobachtungen. Berlin. 1867; 107-110. 
  4. Zegans ME, Svinivasan M, McHugh T. Mooren’s ulcer in South India: serology and chinical risk factors. American Journal of Ophthalmology. 1999; 128:205.  https://doi.org/10.1016/s0002-9394(99)00162-2
  5. Chen J, Xie H, Wang Z, Yang B, Liu Z, Chen L, Gong X, Lin Y. Mooren’s ulcer in China: a study of clinical characteristics and treatment. American Journal of Ophthalmology. 2001;131(2):286-287.  https://doi.org/10.1136/bjo.84.11.1244
  6. Kietzman B. Mooren’s ulcer in Nigeria. American Journal of Ophthalmology. 1968;65(5):679-685.  https://doi.org/10.1016/0002-9394(68)94381-x
  7. Mondino BM. Inflammatory diseases of the peripheral cornea. Ophthalmology. 1988;95:463.  https://doi.org/10.1016/s0161-6420(88)33164-7
  8. Watson P. Management of Mooren’s ulceration. Eye. 1997;11(3):349-356.  https://doi.org/10.1038/eye.1997.74
  9. Kaufman HE, Wood TO. Mooren’s ulcer. American Journal of Ophthalmology. 1971;71:417.  https://doi.org/10.1016/0002-9394(71)90420-x
  10. Kim DH, Kim MK, Wee WR, Youn J. Mooren’s Ulcer in a Cornea Referral Practice in Korea. Ocular Immunology and Inflammation. 2014;24(1):55-59.  https://doi.org/10.3109/09273948.2014.926938
  11. Sharma A. Management of Mooren’s Ulcer. Surgical Techniques in Ophthalmology: Corneal Surgery. 2010;265.  https://doi.org/10.5005/jp/books/11369_43
  12. Brown SI, Mondino BJ. Therapy of Mooren’s ulcer. American Journal of Ophthalmology. 1984;98:1.  https://doi.org/10.1016/0002-9394(84)90179-x
  13. Yang L, Xiao J, Wang J, Zhang H. Clinical Characteristics and Risk Factors of Recurrent Mooren’s Ulcer. Journal of Ophthalmology. 2017;1-7.  https://doi.org/10.1155/2017/8978527
  14. Clinch TE, Laibson PR. Mooren’s Ulcer. Archives of Ophthalmology. 1988; 106(5):691-691.  https://doi.org/10.1001/archopht.1988.01060130753038
  15. Parunović A, Brkić S, Vučković S. Corneal perforation in Mooren’s ulcer — immunological and clinical follow-up. Graefe’s Archive for Clinical and Experimental Ophthalmolog. 1988;226(4):330-331.  https://doi.org/10.1007/bf02172961
  16. Wilson SE, Awan JO, Moazami C. Hepatitis C virus associated with Mooren’s ulcer, Castroviejo Society Presentation, San Francisco, California, October, 1994. https://doi.org/10.1016/s0161-6420(94)31291-7
  17. Pluznik D, Butrus SI. Hepatitis C associated peripheral corneal ulceration. Cornea. 2001;20(8):888-889.  https://doi.org/10.1097/00003226-200111000-00023
  18. Khawaja KS. Mooren’s ulcer or peripheral ulcerative keratitis. British Journal of Ophthalmology. 2012;96(8):1146.2-1146. https://doi.org/10.1136/bjophthalmol-2012-301875
  19. Shinomiya K, Ueta M, Sotozono C, Inatomi T, Yokoi N, Koizumi N, Kinoshita S. Immunohistochemical analysis of inflammatory limbal conjunctivaadjacent to Mooren’s ulcer. British Journal of Ophthalmology. 2013; 97(3):362-366.  https://doi.org/10.1136/bjophthalmol-2012-302631
  20. Schaap OL, Feltkamp TE, Breebaart AC. Circulating antibodies to corneal tissue in a patient suffering from Mooren’s ulcer (ulcus rodens corneae). Clinical & Experimental Immunology. 1969;5(4):365-370. 
  21. Aviel E. Combined cryoapplications and peritomy in Mooren’s ulcer. British Journal of Ophthalmology. 1972;56(1):48-51.  https://doi.org/10.1136/bjo.56.1.48
  22. Gottsch JD. Autoimmune Keratitis. Uveitis and Immunological Disorders. 77-90.  https://doi.org/10.1007/978-3-540-30798-3_5
  23. Zaidman GW, Mondino BJ. Mooren’s ulcer. In: Krachmer J.H, Mannis MJ, Holland EJ, eds. Cornea. 2nd ed. London: ElsevierMosby; 2005.
  24. Murray PI, Rahi AH. Pathogenesis of Mooren’s ulcer: some new concepts. British Journal of Ophthalmology. 1984;68(3):182-187.  https://doi.org/10.1136/bjo.68.3.182
  25. Alhassan MB, Rabiu M, Agbabiaka IO. Interventions for Mooren’s ulcer. Cochrane Database Syst Rev. 2011;15;(6):6-11.  https://doi.org/10.1002/14651858.CD006131.pub2
  26. Taylor CJ, Smith SI, Morgan CH, et al. HLA and Mooren’s ulceration. Br J Ophthalmol. 2000;84(1):72-75.  https://doi.org/10.1136/bjo.84.1.72
  27. Mondino BJ, Brown SI, Rabin BS. Cellular Immunity in Mooren’s Ulcer. American Journal of Ophthalmology. 1978;85(6):788-791.  https://doi.org/10.1016/s0002-9394(14)78106-1
  28. Kobayashi A, Yoshita T, Sugiyama K. In vivo findings of the bulbar/palpebral conjunctiva and presumed meibomian glands by laser scanning confocal microscopy. Cornea. 2005;24:985-988.  https://doi.org/10.1097/01.ico.0000160976.88824.2b
  29. Pandya HK. Mooren Ulcer. Book Encyclopedia of Ophthalmology. 2018; 1164-1165. https://doi.org/10.1007/978-3-540-69000-9_759
  30. Riks IA, Tkachenko NV. To the problem of differential diagnosis of mooren’s ulcerand terrien’s marginal degeneration. Oftalmologicheskie vedomosti. 2008; 1(2):77-83. 
  31. Kanski JJ. Clinical ophthalmology. A Systematic Approach. 6th edition. New York: Butterworth Heinemann Elsevier; 2007.
  32. Lopez JS, Price FW, Whitcup SM, et al. Immunohistochemistry of Terrien’s and Mooren’s corneal degeneration. Archieves of Ophthalmology. 1991; 109(7):988.  https://doi.org/10.1001/archopht.1991.01080070100045
  33. Yagci A. Update on peripheral ulcerative keratitis. Clinical Ophthalmology. 2012;6:747-754.  https://doi.org/10.2147/opth.s24947
  34. Brown SI. Mooren’s ulcer-treatment by conjunctival excision. British Journal of Ophthalmology. 1975;59(11):675-682.  https://doi.org/10.1136/bjo.59.11.675
  35. Brown SI, Mondino BJ, Rabin BC. Autoimmune phenomenon in Mooren’s ulcer. American Journal of Ophthalmology. 1976;82(6):835-840.  https://doi.org/10.1016/0002-9394(76)90058-1
  36. Foster CS. Systemic immunosuppressive therapy for progressive bilateral Mooren’s ulcer. Ophthalmology. 1985;92(10):1436-1439. https://doi.org/10.1016/s0161-6420(85)33845-9
  37. Wakefield D, Robinson LP. Cyclosporin therapy in Mooresn’s ulcer. British Journal of Ophthalmology. 1987;71(6):415-417.  https://doi.org/10.1136/bjo.71.6.415
  38. Ferguson EC, Octavio B. Moorenʼs Ulcer and Delimiting Keratotomy*. Southern Medical Journal. 1969;62(10):1170-1174. https://doi.org/10.1097/00007611-196910000-00002
  39. Xie H, Chen J, Gong X, et al. A study of clinical characteristics and treatment of Mooren’s ulcer. Yan Ke Xue Bao. 1998;14(3):164-169. 
  40. Solomon A, Meller D, Prabhasawat P, et al. Amniotic membrane grafts for nontraumatic corneal perforations, descemetoceles and deep ulcers. Ophthalmology. 2002;109(4):694-703.  https://doi.org/10.1016/s0161-6420(01)01032-6
  41. Brown SI, Mondino Bj. Penetrating keratoplasty in Mooren’s ulcer. American Journal of Ophthalmology. 1980;899(2):255-258.  https://doi.org/10.1016/0002-9394(80)90120-8
  42. Spelsberg H, Sundmacher R. Amniotic Membrane Transplantation and High-Dose Systemic Cyclosporin A (Sandimmun optoral) for Mooren’s Ulcer. Klinische Monatsblätter für Augenheilkunde. 2007;224(2):135-139.  https://doi.org/10.1055/s-2006-927400
  43. Nguyen D Ngan, Hoang TM Chau. Amniotic membrane transplantation for Mooren’s ulcer. Clinical & Experimental Ophthalmology. 2011;39(5):386-392.  https://doi.org/10.1111/j.1442-9071.2010.02479.x
  44. Chendran P, Hsien YM, Wan Haslina Wan Abdul Halim. Multifacet of Cornea Patch Graft in Anterior Segment Diseases. Ophthalmological Medicine. 2019;1-5.  https://doi.org/10.1155/2019/6862487
  45. Cellini M, Fresina M, Strobbe E, Gizzi C. Corneoscleral graft in Mooren’s ulcer: a case report. Campos Cases Journal. 2009;2:180.  https://doi.org/10.1186/1757-1626-2-180
  46. Kinoshita S, Ohashi Y, Ohji M. Long-term results of keratoepithelioplasty in Mooren’s ulcer. Ophthalmology. 1991;98(4):438-445.  https://doi.org/10.1016/s0161-6420(91)32272-3
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.