Endophthalmitis is characterized by inflammation of intraocular fluids and tissues, which can lead to irreversible loss of vision if the disease is not treated timely and properly. Endophthalmitis can be classified as exogenous or endogenous depending on the route of infectious agent transmission. Exogenous endophthalmitis occurs when pathogens enter the eye through direct inoculation, while endogenous endophthalmitis develops when pathogens get into the eye through the hematogenous route from a distant infection focus. Classification of endophthalmitis helps determine the etiology and probable causative organisms of the disease. Diagnosis of endophthalmitis is based on clinical data. Early diagnosis and treatment are keys to preserving the eye. Best results are achieved by rapid initiation of an empirical broad-spectrum antimicrobial therapy.