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Safonova T.N.

FGBU "NII glaznykh bolezneĭ" RAMN, Moskva

Kintukhina N.P.

Research Institute of Eye Diseases, 11 A, B, Rossolimo St., Moscow, Russian Federation, 119021

Sidorov V.V.

Pirogov Russian National Research Medical University, Moscow

Treatment of chronic blepharitis

Authors:

Safonova T.N., Kintukhina N.P., Sidorov V.V.

More about the authors

Journal: Russian Annals of Ophthalmology. 2020;136(1): 97‑102

Read: 38435 times


To cite this article:

Safonova TN, Kintukhina NP, Sidorov VV. Treatment of chronic blepharitis. Russian Annals of Ophthalmology. 2020;136(1):97‑102. (In Russ.)
https://doi.org/10.17116/oftalma202013601197

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References:

  1. Safonova TN, Kintyukhina NP, Petrenko AE, Gladkova OV. Prevention of dry eye syndrome in chronic demodex blepharitis. RMZh. Klinicheskaya oftal’mologiya. 2016;16(2):89-93. (In Russ.). https://doi.org/10.21689/2311-7729-2016-16-2-89-93
  2. Akcinar UG, Unal E, Akpinar M. Demodex spp. Infestation Associated with Treatment-Resistant Chalazia and Folliculitis. Turkiye parazitolojii dergisi. 2016;40(4):208-210. https://doi.org/10.5152/tpd.2016.4869
  3. Bezza Benkaouha I, Le Brun C, Pisella PJ, Chandenier J, Lanotte P. Bacterial flora in blepharitis. Journal francais d’ophtalmologie. 2015;38(8):723–728. https://doi.org/10.1016/j.jfo.2015.01.012
  4. Lindsley K, Matsumura S, Hatef E, Akpek EK. Interventions for chronic blepharitis. Cochrane Database Syst Rev. 2012(5):CD005556. https://doi.org/10.1002/14651858.CD005556.pub2
  5. Safonova TN, Vasil’ev VI, Lihvanceva VG. Sogren’s syndrome. M.: Izdatel’stvo Moskovskogo Universiteta; 2013. (In Russ.).
  6. Safonova TN, Kintyukhina NP., Sidorov VV, Gladkova OV., Reyn ES. Microcirculatory blood and lymph flow examination in eyelid skin by laser Doppler flowmetry. Vestnik oftal’mologii. 2017;133(3):16–21. (In Russ.). https://doi.org/10.17116/oftalma2017133316-21
  7. Safonova TN, Lucevich EE, Kintyukhina NP. Microcirculatory changes in bulbar conjunctiva in various diseases. Vestnik oftal’mologii. 2016; 132 (2): 90-95. (In Russ.). https://doi.org/10.17116/oftalma2016132290-95
  8. Safonova T.N., Kintyukhina N.P. Involutionary blepharitis: a modern approach to diagnostics and treatment. Vestnik oftal’mologii. 2018; 134 (1): 43-47. (In Russ.). https://doi.org/10.17116/oftalma2016132290-95
  9. Devambez H, Richeux M, Guericolas M, Choquet C, Casalino E, Ghazali AD. Eyelid inflammation: An uncommon cause in occidental countries. The American journal of emergency medicine. 2017;35(11):1789 e1783-1789 e1785. https://doi.org/10.1016/j.ajem.2017.08.021
  10. Shokirova MM, Kopayeva VG. Evaluation of pathogenetic component of lacrimal substitutive therapy in the complex stage-by-stage treatment of posterior blepharitis, associated with demodectic lesions of the eyelid margins. Oftalmokhirurgiya. 2017;(1):78-82. (In Russ.). https://doi.org/10.25276/0235-4160-2017-1-78-82
  11. Polunin GS, Zabegailo AO, Makarov IA, Safonova TN. The effectiveness of therapeutic eyelid hygiene in the treatment of patients with blepharoconjunctival dry eye syndrome. Vestnik oftal’mologii. 2011;128(1):37-41. (In Russ.).
  12. Auw-Hadrich C, Reinhard T. [Blepharitis component of dry eye syndrome]. Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft. 2018;115(2):93–99. https://doi.org/10.1007/s00347-017-0606-8
  13. Egorova GB, Fedorov AA, Mitichkina TS, Shamsudinova AR, Safonova TN. The effect of tear-replacement and corneoprotective therapy on the condition of the eye surface with the “dry eye” syndrome. RMZh «Klinicheskaya Oftal’mologiya». 2015(1):15-21. (In Russ.).
  14. Korb DR, Blackie CA, Finnemore VM, Douglass T. Effect of using a combination of lid wipes, eye drops, and omega-3 supplements on meibomian gland functionality in patients with lipid deficient/evaporative dry eye. Cornea. 2015;34(4):407-412. https://doi.org/10.1097/ICO.0000000000000366
  15. Borovskih EV, Borobova IM, Egorov VV. The microbial spectrum and sensitivity to antibiotics of the microflora found in children with inflammatory diseases of the eye. Oftal’mologicheskie vedomosti. 2014;1:13-18. (In Russ.).
  16. Haque RM, Torkildsen GL, Brubaker K, Zink RC, Kowalski RP, Mah FS, Pflugfelder SC. Multicenter open-label study evaluating the efficacy of azithromycin ophthalmic solution 1% on the signs and symptoms of subjects with blepharitis. Cornea. 2010;29(8):871-877. https://doi.org/10.1097/ICO.0b013e3181ca38a0
  17. Opitz DL, Tyler KF. Efficacy of azithromycin 1% ophthalmic solution for treatment of ocular surface disease from posterior blepharitis. Clin Exp Optom. 2011;94(2):200-206. https://doi.org/10.1111/j.1444-0938.2010.00540.x
  18. Veldman P, Colby K. Current evidence for topical azithromycin 1% ophthalmic solution in the treatment of blepharitis and blepharitis-associated ocular dryness. Int Ophthalmol Clin. 2011;51(4):43–52. https://doi.org/10.1097/IIO.0b013e31822d6af1
  19. Zhang L, Su Z, Zhang Z, Lin J, Li DQ, Pflugfelder SC. Effects of azithromycin on gene expression profiles of proinflammatory and anti-inflammatory mediators in the eyelid margin and conjunctiva of patients with meibomian gland disease. JAMA ophthalmology. 2015;133(10):1117–1123. https://doi.org/10.1001/jamaophthalmol.2015.2326
  20. Mandal P, Khan MA, Shah S. Drugs - Do we need them? Applications of non-pharmaceutical therapy in anterior eye disease: A review. Contact lens & anterior eye : the journal of the British Contact Lens Association. 2017;40(6):360–366. https://doi.org/10.1016/j.clae.2017.09.001
  21. Kirichenko NA. Prospects for the use of antiseptics for the treatment and prevention of infectious and inflammatory diseases in ophthalmology. Kataraktal’naya i refrakcionnaya hirurgiya. 2012;1:63-65. (In Russ.).
  22. Makarov IA. The role of the Okomistin antimicrobial drug in the complex treatment of chronic blepharoconjunctivitis. Novoe v oftal’mologii. 2016;1:38-42. (In Russ.).
  23. Arrua M, Samudio M, Farina N, Cibils D, Laspina F, Sanabria R, Carpinelli L, Mino de Kaspar H. Comparative study of the efficacy of different treatment options in patients with chronic blepharitis. Archivos de la Sociedad Espanola de Oftalmologia. 2015;90(3):112-118. https://doi.org/10.1016/j.oftal.2013.09.003
  24. Zandian M, Rahimian N, Soheilifar S. Comparison of therapeutic effects of topical azithromycin solution and systemic doxycycline on posterior blepharitis. International journal of ophthalmology. 2016;9(7):1016–1019. https://doi.org/10.18240/ijo.2016.07.14
  25. Igami TZ, Holzchuh R, Osaki TH, Santo RM, Kara-Jose N, Hida RY. Oral azithromycin for treatment of posterior blepharitis. Cornea. 2011;30(10):1145–1149. https://doi.org/10.1097/ICO.0b013e318207fc42
  26. Kilic Muftuoglu I, Aydin Akova Y. Clinical Findings, Follow-up and Treatment Results in Patients with Ocular Rosacea. Turkish journal of ophthalmology. 2016;46(1):1-6. https://doi.org/10.4274/tjo.48902
  27. Belfort R, Jr, Gabriel L, Martins Bispo PJ, Muccioli C, Zacharias Serapicos PC, Clark L, Bell B, Bartell J, Stroman DW, Hofling-Lima AL. Safety and efficacy of moxifloxacin-dexamethasone eyedrops as treatment for bacterial ocular infection associated with bacterial blepharitis. Advances in therapy. 2012;29(5):416-426. https://doi.org/10.1007/s12325-012-0018-8
  28. Hosseini K, Lindstrom RL, Foulks G, Nichols KK. A randomized, double-masked, parallel-group, comparative study to evaluate the clinical efficacy and safety of 1% azithromycin-0.1% dexamethasone combination compared to 1% azithromycin alone, 0.1% dexamethasone alone, and vehicle in the treatment of subjects with blepharitis. Clinical ophthalmology. 2016;10:1495-1503. https://doi.org/10.2147/OPTH.S110739
  29. Kiseleva TN. Omega-3 polyunsaturated fatty acids: role in the pathogenesis of eye diseases and prospects for use in ophthalmology. Vestnik oftal’mologii. 2010;6:58-62. (In Russ.).
  30. Deinema LA, Vingrys AJ, Wong CY, Jackson DC, Chinnery HR, Downie LE. A Randomized, Double-Masked, Placebo-Controlled Clinical Trial of Two Forms of Omega-3 Supplements for Treating Dry Eye Disease. Ophthalmology. 2017;124(1):43-52. https://doi.org/10.1016/j.ophtha.2016.09.023
  31. Nanavaty MA, Long M, Malhotra R. Transdermal androgen patches in evaporative dry eye syndrome with androgen deficiency: a pilot study. The British journal of ophthalmology. 2014;98(4):567-569. https://doi.org/10.1136/bjophthalmol-2013-304637
  32. Sakassegawa-Naves FE, Ricci HMM, Moscovici BK, Miyamoto DA, Chiacchio BB, Holzchuh R, Santo RM, Hida RY. Tacrolimus Ointment for Refractory Posterior Blepharitis. Current eye research. 2017;42(11):1440-1444. https://doi.org/10.1080/02713683.2017.1339805
  33. Majchuk DYU, Vasil’eva OA, Shokirova MM. The use of 0.05% cyclosporine for various diseases of the ocular surface. Vestnik oftal’mologii. 2014;2:68-71. (In Russ.).
  34. Majchuk DYU, Shokirova MM, Simonova TA, Malysheva ZG. Correlation of the formation of demodectic lesions of the skin of the face and eyelids and some approaches to their complex treatment. Oftal’mologiya. 2015;12(1):63-68. (In Russ.).
  35. Safonova TN. Kintyukhina NP, Petrenko A E, Gladkova OV. First experience of “Deksodem phyto” use in treating chronic demodex blepharitis. Tochka zrenija. Vostok – Zapad. 2016;1:145-147. (In Russ.).
  36. Safonova TN, Kintyukhina NP., Sidorov VV, Gladkova OV. Laser doppler flowmetry in assessing the effectiveness of treatment of chronic demodex blefaritis. Rossiiskii oftal’mologicheskii zhurnal. 2017;10(2):62-66. (In Russ.).
  37. Bhandari V, Reddy JK. Blepharitis: always remember demodex. Middle East African journal of ophthalmology. 2014;21(4):317-320. https://doi.org/10.4103/0974-9233.142268
  38. Gonzalez-Hinojosa D, Jaime-Villalonga A, Aguilar-Montes G, Lammoglia-Ordiales L. Demodex and rosacea: Is there a relationship? Indian journal of ophthalmology. 2018;66(1):36–38. https://doi.org/10.4103/ijo.IJO_514_17
  39. Mongi F, Laconte L, Casero RD. [Demodex genus: colonizing parasites of healthy people or mites associated with ocular pathology?]. Revista Argentina de microbiologia. 2018. https://doi.org/10.1016/j.ram.2017.09.002
  40. Safonova TN, Zabegajlo AO, Fedorov AA, Lukicheva OV. A new method for the treatment of chronic blepharitis associated with dry eye syndrome. Vestnik oftal’mologii. 2014;1:73-78. (In Russ.).
  41. Hagen KB, Bedi R, Blackie CA, Christenson-Akagi KJ. Comparison of a single-dose vectored thermal pulsation procedure with a 3-month course of daily oral doxycycline for moderate-to-severe meibomian gland dysfunction. Clinical ophthalmology. 2018;12:161-168. https://doi.org/10.2147/OPTH.S150433
  42. Rong B, Tang Y, Tu P, Liu R, Qiao J, Song W, Toyos R, Yan X. Intense Pulsed Light Applied Directly on Eyelids Combined with Meibomian Gland Expression to Treat Meibomian Gland Dysfunction. Photomed Laser Surg. 2018;36(6):326-332. https://doi.org/10.1089/pho.2017.4402
  43. Liu R, Rong B, Tu P, Tang Y, Song W, Toyos R, Toyos M, Yan X. Analysis of Cytokine Levels in Tears and Clinical Correlations After Intense Pulsed Light Treating Meibomian Gland Dysfunction. American journal of ophthalmology. 2017;183:81-90. https://doi.org/10.1016/j.ajo.2017.08.021
  44. Murphy O, O’Dwyer V, Lloyd-McKernan A. Ocular Demodex folliculorum: prevalence and associated symptoms in an Irish population. International ophthalmology. 2018. https://doi.org/10.1007/s10792-018-0826-1
  45. Murphy O, O’Dwyer V, Lloyd-McKernan A. The efficacy of tea tree face wash, 1, 2-Octanediol and microblepharoexfoliation in treating Demodex folliculorum blepharitis. Contact lens & anterior eye : the journal of the British Contact Lens Association. 2018;41(1):77-82. https://doi.org/10.1016/j.clae.2017.10.012
  46. Kintyukhina NP, Safonova TN, Gladkova OV. The use of laser scanning confocal microscopy of eyelids during intraprototic probing of meibomian glands. Sovremennye tekhnologii v oftal’mologii. 2017;4:112-114. (In Russ.).
  47. Prozornaja LP, Brzheskij VV. The effectiveness of physiotherapeutic and hygienic procedures in the treatment of children and adults with chronic blepharitis and the “dry eye” syndrome. Vestnik oftal’mologii. 2013;129(3):68-73. (In Russ.).
  48. Thode AR, Latkany RA. Current and Emerging Therapeutic Strategies for the Treatment of Meibomian Gland Dysfunction (MGD). Drugs. 2015;75(11):1177-1185. https://doi.org/10.1007/s40265-015-0432-8
  49. Maskin SL. Intraductal meibomian gland probing relieves symptoms of obstructive meibomian gland dysfunction. Cornea. 2010;29(10):1145-1152. https://doi.org/10.1097/ICO.0b013e3181d836f3
  50. Wladis EJ. Intraductal meibomian gland probing in the management of ocular rosacea. Ophthalmic plastic and reconstructive surgery. 2012;28(6):416-418. https://doi.org/10.1097/IOP.0b013e3182627ebc

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