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Smirnova T.V.

FGBU "NII glaznykh bolezneĭ" RAMN, Moskva

Sheludchenko V.M.

FGBU "NII glaznykh bolezneĭ" RAMN, Moskva

Kozlovskaya N.L.

Department of Nephrology and Hemodialysis, I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia;
Research Department of Nephrology, Research Center, I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia, Moscow, Russia

Kazarian É.É.

FGBU "NII glaznykh bolezneĭ" RAMN, Moskva

Andzhelova D.V.

FGBU "NII glaznykh bolezneĭ" RAMN

Sherstneva L.V.

I.M. Sechenov First Moscow State Medical University, Ophthalmology Department, 8-2 Trubetskaya St., Moscow, Russian Federation, 119991

Velieva I.A.

FGBU "NII glaznykh bolezneĭ" RAMN

Kuchieva A.M.

I.M. Sechenov First Moscow State Medical University, 8-2 Trubetskaya St., Moscow, Russian Federation, 119991

Akaeva M.I.

I.M. Sechenov First Moscow State Medical University, 8-2 Trubetskaya St., Moscow, Russian Federation, 119991

Ocular thrombotic microangiopathy in atypical hemolytic-uremic syndrome (a clinical case study)

Authors:

Smirnova T.V., Sheludchenko V.M., Kozlovskaya N.L., Kazarian É.É., Andzhelova D.V., Sherstneva L.V., Velieva I.A., Kuchieva A.M., Akaeva M.I.

More about the authors

Journal: Russian Annals of Ophthalmology. 2018;134(5): 215‑226

DOI: 10.17116/oftalma2018134051215

Read: 1047 times

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Table of contents

OCULAR THROMBOTIC MICROANGIOPATHY IN ATYPICAL HEMOLYTIC-UREMIC SYNDROME (A CLINICAL CASE STUDY)
OCULAR THROMBOTIC MICROANGIOPATHY IN ATYPICAL HEMOLYTIC-UREMIC SYNDROME (A CLINICAL CASE STUDY)

To cite this article:

Smirnova TV, Sheludchenko VM, Kozlovskaya NL, et al. . Ocular thrombotic microangiopathy in atypical hemolytic-uremic syndrome (a clinical case study). Russian Annals of Ophthalmology. 2018;134(5):215‑226. (In Russ.)
https://doi.org/10.17116/oftalma2018134051215

Подписка 2026 Вестник офтальмологии (Russian Annals of Ophthalmology)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Recommended articles:
Reti­nopathy asso­ciated with thro­mbotic microangiopathy of mixed origin (case report). Russian Annals of Ophthalmology. 2024;(6):90-99
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Abstract:

The article presents a clinical observation of ocular thrombotic microangiopathy in atypical hemolytic-uremic syndrome — a rare genetic disease characterized by systemic thrombosis caused by uncontrolled activation of alternative complement pathway. A typical manifestation of this ocular lesion in this disease is bilateral Purtscher-like retinopathy. Timely diagnostics of atypical hemolytic-uremic syndrome, including ophthalmologic examination, determines the early start of a highly effective pathogenetic therapy with complement inhibitor eculizumab.

Keywords:

thrombotic microangiopathy
atypical hemolytic-uremic syndrome
complement system
Purtscher-like retinopathy
eculizumab

Authors:

Smirnova T.V.

FGBU "NII glaznykh bolezneĭ" RAMN, Moskva

Sheludchenko V.M.

FGBU "NII glaznykh bolezneĭ" RAMN, Moskva

Kozlovskaya N.L.

Department of Nephrology and Hemodialysis, I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia;
Research Department of Nephrology, Research Center, I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia, Moscow, Russia

Kazarian É.É.

FGBU "NII glaznykh bolezneĭ" RAMN, Moskva

Andzhelova D.V.

FGBU "NII glaznykh bolezneĭ" RAMN

Sherstneva L.V.

I.M. Sechenov First Moscow State Medical University, Ophthalmology Department, 8-2 Trubetskaya St., Moscow, Russian Federation, 119991

Velieva I.A.

FGBU "NII glaznykh bolezneĭ" RAMN

Kuchieva A.M.

I.M. Sechenov First Moscow State Medical University, 8-2 Trubetskaya St., Moscow, Russian Federation, 119991

Akaeva M.I.

I.M. Sechenov First Moscow State Medical University, 8-2 Trubetskaya St., Moscow, Russian Federation, 119991

Close metadata

References:

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  2. Shen Y-M. Clinical evaluation of thrombotic microangiopathy: identification of patients with suspected atypical hemolytic uremic syndrome. Thromb J. 2016;14(suppl 1):19. https://doi.org/10.1186/s12959-016-0114-0
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  9. Ramos de Carvalho JE, Schlingemann RO, Oranje M, Schlingemann RO, Oranje M, Bemelman FJ, Schooneveld MJ. Reversal of threatening blindness after initiation of eculizumab in Purtscher-like retinopathy secondary to atypical hemolytic uremic syndrome. Int Ophthalmol. 2018;38(1):399-407. https://doi.org/10.1007/s10792-017-0470-1
  10. Sampedro Lopez A, Dominguez Moro B, Baltar Martin JM, Garcia Monteavaro C, Barbon Garcia JJ. Ocular involvement in atypical hemolytic uremic syndrome. Arch Soc Esp Oftalmol. 2017;92(12):594-597. https://doi.org/10.1016/j.oftal.2017.02.007
  11. Greenwood GT. Case report of atypical hemolytic uremic syndrome with retinal arterial and venous occlusion treated with eculizumab. Int Med Case Rep J. 2015;13:235-239. https://doi.org/10.2147/imcrj.S90640
  12. David R, Hochberg-Klein S, Amer R. Resolution of ocular involvement with systemic eculizumab therapy in atypical hemolytic — uremic syndrome. Eye. 2013;27:997-998. https://doi.org/10.1038/eye.2013.111
  13. Zheng X, Gorovoy IR, Mao J, Jin J, Chen X, Cui QN. Recurrent ocular involvement in pediatric atypical hemolytic uremic syndrome. J Pediatr Ophthalmol Strabismus. 2014;51:62-65. https://doi.org/10.3928/01913913-20140923-03
  14. Larakeb A, Leroy S, Fremeaux-Bacchi V, Montchilova M, Pelosse B, Dunand O, Deschenes G, Bensman A, Ulinski T. Ocular involvement in hemolytic uremic syndrome due to factor H deficiency — are there therapeutic consequences? Pediatr Nephrol. 2007;22:1967-1970. https://doi.org/10.1007/s00467-007-0540-0
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  17. Miguel AIM, Henriques F, Azevedo LFR, Loureiro AJR, Maberley DAL. Systematic review of Purtscher′s and Purtscher-like retinopathies. Eye. 2013;27(1):1-13. https://doi.org/10.1038/eye.2012.222
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