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Rud’ko A.S.

Research Institute of Eye Disease, 11 A, B, Rossolimo St., Moscow, Russia, 119021

Efendieva M.Kh.

Research Institute of Eye Disease, 11 A, B, Rossolimo St., Moscow, Russia, 119021

Budzinskaia M.V.

FGBU "Nauchno-issledovatel'skiĭ institut glaznykh bolezneĭ" RAMN, Moskva

Karpilova M.A.

FGBU "Nauchno-issledovatel'skiĭ institut glaznykh bolezneĭ" RAMN, Moskva

Influence of vascular endothelial growth factor on angiogenesis and neurogenesis

Authors:

Rud’ko A.S., Efendieva M.Kh., Budzinskaia M.V., Karpilova M.A.

More about the authors

Journal: Russian Annals of Ophthalmology. 2017;133(3): 75‑81

Read: 5271 times


To cite this article:

Rud’ko AS, Efendieva MKh, Budzinskaia MV, Karpilova MA. Influence of vascular endothelial growth factor on angiogenesis and neurogenesis. Russian Annals of Ophthalmology. 2017;133(3):75‑81. (In Russ.)
https://doi.org/10.17116/oftalma2017133375-80

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References:

  1. Marri RD Grenner, Meyes P, Roduell V. Biochemistry of the person. M.: «MIR»; 1993;2:363-364. (In Russ.)
  2. Giet M, Henkel C, Schuchardt M, Tolle M. Anti-VEGF Drugs in Eye Diseases: Local Therapy with Potential Systemic Effects. CPD. 2015;21(24):3548-3556. https://doi.org/10.2174/1381612821666150225120314
  3. Ferrara N, Gerber H, LeCouter J. The biology of VEGF and its receptors. Nature Medicine. 2003;9(6):669-676. https://doi.org/10.1038/nm0603-669
  4. Nishijima K, Ng Y, Zhong L, Bradley J, Schubert W, Jo N, Akita J, Samuelsson S, Robinson G, Adamis A, Shima D. Vascular Endothelial Growth Factor-A Is a Survival Factor for Retinal Neurons and a Critical Neuroprotectant during the Adaptive Response to Ischemic Injury. The American Journal of Pathology. 2007;171(1):53-67. https://doi.org/10.2353/ajpath.2007.061237
  5. Penn J, Madan A, Caldwell R, Bartoli M, Caldwell R, Hartnett M. Vascular endothelial growth factor in eye disease. Progress in Retinal and Eye Research. 2008;27(4):331-371. https://doi.org/10.1016/j.preteyeres.2008.05.001
  6. Tammela T, Enholm B, Alitalo K, Paavonen K. The biology of vascular endothelial growth factors. Cardiovasc Res. 2005;65:550-563. https://doi.org/10.1016/j.cardiores.2004.12.002
  7. Holmes DIR, Zachary I. The vascular endothelial growth factor family: angiogenic factors in health and disease. Genome Biol. 2005;6:209. https://doi.org/10.1186/gb-2005-6-2-209
  8. Carmeliet P, Ng YS, Nuyens D, Theilmeier G, Brusselmans K, Cornelissen I et al. Impaired myocardial angiogenesis and ischemic cardiomyopathy in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188. Nat Med. 1999;5:495-502. https://doi.org/10.1038/8379 
  9. Stalmans I, Ng Y, Rohan R, Fruttiger M, Bouché A, Ÿuce A, Fujisawa H et al. Arteriolar and venular patterning in retinas of mice selectively expressing VEGF isoforms. Journal of Clinical Investigation. 2002;109(3):327-336. https://doi.org/10.1172/jci14362 
  10. Bellomo D, Headrick J, Silins G, Paterson C, Thomas P, Gartside M et al. Mice Lacking the Vascular Endothelial Growth Factor-B Gene (Vegfb) Have Smaller Hearts, Dysfunctional Coronary Vasculature, and Impaired Recovery From Cardiac Ischemia. Circulation Research. 2000;86(2):29-35. https://doi.org/10.1161/01.res.86.2.e29 
  11. Mould A, Tonks I, Cahill M, Pettit A, Thomas R, Hayward N, Kay G. Vegfb gene knockout mice display reduced pathology and synovial angiogenesis in both antigen-induced and collagen-induced models of arthritis. Arthritis & Rheumatism. 2003;48(9):2660-2669. https://doi.org/10.1002/art.11232
  12. Alpatov SA, Shchuko AG. Age-related macular degeneration. M.: «GEOTAR»; 2015:35-36. (In Russ.)
  13. Meyer M, Clauss M, Lepple‐Wienhues A, Waltenberger J, Hellmut G. A novel vascular endothelial growth factor encoded by Orf virus, VEGF‐E, mediates angiogenesis via signalling through VEGFR‐2 (KDR) but not VEGFR‐1 (Flt‐1) receptor tyrosine kinases. The EMBO Journal. 1999;18:363-374. https://doi.org/10.1093/emboj/18.2.363
  14. Waltenberger J, Claesson Welsh L, Siegbahn A, Shibuya M, Heldin CH. Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor. Journal of Biological Chemistry. 1994; 269:26988-26995.
  15. Seetharam L, Gotoh N, Maru Y, Neufeld G, Yamaguchi S, Shibuya M. A unique signal transduction from FLT tyrosine kinase, a receptor for vascular endothelial growth factor VEGF. Oncogene. 1995;10(1):135-147.
  16. Hiratsuka S, Minowa O, Kuno J, Noda T, Shibuya M. Flt-1 lacking the tyrosine kinase domain is sufficient for normal development and angiogenesis in mice. Proceedings of the National Academy of Sciences. 1998;95(16):9349-9354. https://doi.org/10.1073/pnas.95.16.9349
  17. Kondo K, Hiratsuka S, Subbalakshmi E, Matsushime H, Shibuya M. Genomic organization of the flt-1 gene encoding for vascular endothelial growth factor (VEGF) receptor-1 suggests an intimate evolutionary relationship between the 7-Ig and the 5-Ig tyrosine kinase receptors. Gene. 1998;208(2):297-305. https://doi.org/10.1016/s0378-1119(98)00006-7 
  18. Aiello L, Pierce E, Foley E, Takagi H, Chen H, Riddle L, Ferrara N, King G, Smith L. Suppression of retinal neovascularization in vivo by inhibition of vascular endothelial growth factor (VEGF) using soluble VEGF-receptor chimeric proteins. Proceedings of the National Academy of Sciences. 1995;92(23):10457-10461. https://doi.org/10.1073/pnas.92.23.10457
  19. Ambati B, Nozaki M, Singh N, Takeda A, Jani P et al. Corneal avascularity is due to soluble VEGF receptor-1. Nature. 2006;443(7114):993-997. https://doi.org/10.1038/nature05249 
  20. Richard H. Foxton, Finkelstein A., Vijay S. et al. VEGF-A Is Necessary, Sufficient for Retinal Neuroprotection in Models of Experimental Glaucoma. The American Journal of Pathology. 2013;182:1379-1390. https://doi.org/10.1016/j.ajpath.2012.12.032
  21. Carmeliet P. Angiogenesis in health and disease. Nature Medicine. 2003;9(6):653-660. https://doi.org/10.1038/nm0603-653
  22. Carmeliet P, Ferreira V, Breier G, Pollefeyt S, Kieckens L, Gertsenstein M, Fahrig M et al. Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature. 1996;380(6573):435-439. https://doi.org/10.1038/380435a0
  23. Lanahan A, Hermans K, Claes F, Kerley-Hamilton J, Zhuang Z, Giordano F, Carmeliet P, Simons M. VEGF Receptor 2 Endocytic Trafficking Regulates Arterial Morphogenesis. Developmental Cell. 2010;18(5):713-724. https://doi.org/10.1016/j.devcel.2010.02.016
  24. Jain R, Duda D, Willett C, Sahani D, Zhu A, Loeffler J, Batchelor T, Sorensen A. Biomarkers of response and resistance to antiangiogenic therapy. Nature Reviews Clinical Oncology. 2009:6(6):327-338. https://doi.org/10.1038/nrclinonc.2009.63
  25. Olsson A, Dimberg A, Kreuger J, Claesson-Welsh L. VEGF receptor signalling — in control of vascular function. Nature Reviews Molecular Cell Biology. 2006;7(5):359-371. https://doi.org/10.1038/nrm1911
  26. Neufeld G, Kessler O. The semaphorins: versatile regulators of tumour progression and tumour angiogenesis. Nature Reviews Cancer. 2008;8(8):632-645. https://doi.org/10.1038/nrc2404
  27. Djordjevic S, Driscoll P. Targeting VEGF signalling via the neuropilin co-receptor. Drug Discovery Today. 2013;18(9-10):447-455. https://doi.org/10.1016/j.drudis.2012.11.013
  28. Fujisawa H, Kitsukawa T, Kawakami A, Takagi S, Shimizu M, Hirata T. Roles of a neuronal cell-surface molecule, neuropilin, in nerve fiber fasciculation and guidance. Cell and Tissue Research. 1997;290(2):465-470. https://doi.org/10.1007/s004410050954
  29. Carmeliet P, Tessier-Lavingne M. Common mechanisms of nerve and blood vessel wiring. Nature. 2005;436:193-200. https://doi.org/10.1038/nature03875
  30. Mackenzie F, Ruhrberg C. Diverse roles for VEGF-A in the nervous system. Development. 2012:139(8):1371-1380. https://doi.org/10.1242/dev.072348
  31. Wang B, Jin K. Current perspectives on the link between neuroinflammation and neurogenesis. Metabolic Brain Disease. 2014;30(2):355-365. https://doi.org/10.1007/s11011-014-9523-6
  32. Palmer TD, Willhoite AR, Gage FH. Vascular niche for adult hippocampal neurogenesis. Journal of Comparative Neurology. 2000;425:479-494. https://doi.org/10.1002/1096-9861(20001002)425:4<479::AID-CNE2>3.0.CO;2-3
  33. Yang S, Zhang L, Huang Y, Sun F. Distribution of Flk-1 and Flt-1 receptors in neonatal and adult rat brains. The Anatomical Record. 2003;274A(1):851-856. https://doi.org/10.1002/ar.a.10103
  34. Jin K, Zhu Y, Sun Y et al. Vascular endothelial growth factor (VEGF) stimulates neurogenesis in vitro and in vivo. Proceedings of the National Academy of Sciences of the USA. 2002;99:11946-11950. https://doi.org/10.1073/pnas.182296499
  35. Storkebaum E, Lambrechts D, Dewerchin M, Moreno-Murciano MP, Appelmans S, Oh H et al. Treatment of motoneuron degeneration by intracerebroventricular delivery of VEGF in a rat model of ALS. Nature Neuroscience. 2005;8:85-92. https://doi.org/10.1038/nn1360 
  36. Hayashi T, Abe K, Itoyama Y. Reduction of ischemic damage by application of vascular endothelial growth factor in rat brain after transient ischemia. Journal of Cerebral Blood Flow and Metabolism. 1998;18:887-895. https://doi.org/10.1097/00004647-199808000-00009
  37. Beazley-Long N, Hua J, Jehle T, Hulse RP, Dersch R. VEGF-A165b Is an Endogenous Neuroprotective Splice Isoform of Vascular Endothelial Growth Factor A in Vivo and in Vitro. The American Journal of Pathology. 2013:183:918-929. https://doi.org/10.1016/j.ajpath.2013.05.031
  38. Feng Y, Rhodes PG, Bhatt AJ. Neuroprotective effects of vascular endothelial growth factor following hypoxic ischemic brain injury in neonatal rats. Pediatric research. 2008;64:370-374. https://doi.org/10.1203/pdr.0b013e318180ebe6
  39. Sun Y, Jin K, Xie L, Childs J et al. VEGF-induced neuroprotection, neurogenesis, and angiogenesis after focal cerebral ischemia. The Journal of Clinical Investigations. 2003;111:1843-1851. https://doi.org/10.1172/jci17977
  40. Ruan L, Wang B, ZhuGe Q, Jin K. Coupling of neurogenesis and angiogenesis after ischemic stroke. Brain Research. 2015;1623:166-173. https://doi.org/10.1016/j.brainres.2015.02.042
  41. Carmeliet P, Jain RK. Molecular mechanisms and clinical applications of angiogenesis. Nature. 2011;473:298-307. https://doi.org/10.1038/nature10144
  42. Risau W. Mechanisms of angiogenesis. Nature. 1997;386:671-674. https://doi.org/10.1038/386671a0
  43. Plate KH, Beck H, Danner S, Allegrini PR, Wiessner C. Cell type specific upregulation of vascular endothelial growth factor in an MCA-occlusion model of cerebral infarct. Journal of Neuropathology & Experimental Neurology. 1999;58:654-666. https://doi.org/10.1097/00005072-199906000-00010
  44. Zhang ZG, Zhang L, Tsang W, Soltanian-Zadeh H et al. Correlation of VEGF and angiopoietin expression with disruption of blood-brain barrier and angiogenesis after focal cerebral ischemia. Journal of Cerebral Blood Flow and Metabolism. 2002;22:379-392. https://doi.org/10.1097/00004647-200204000-00002
  45. Krum JM, Mani N, Rosenstein JM. Angiogenic and astroglial responses to vascular endothelial growth factor administration in adult rat brain. The Neuroscience. 2002;110:589-604. https://doi.org/10.1016/s0306-4522(01)00615-7
  46. Jin K, Wang X, Xie L, Mao X, Zhu W, Wang Y, Shen J, Mao Y, Banwait S, Greenberg D. Evidence for stroke-induced neurogenesis in the human brain. Proceedings of the National Academy of Sciences. 2006;103(35):13198-13202. https://doi.org/10.1073/pnas.0603512103 
  47. Ohab JJ, Fleming S, Blesch A, Carmichael ST. A neurovascular niche for neurogenesis after stroke. Neuroscience. 2006;26:13007-13016. https://doi.org/10.1523/jneurosci.4323-06.2006
  48. Thored P, Wood J, Arvidsson A, Cammengaet J et al. Long-term neuroblast migration along blood vessels in an area with transient angiogenesis and increased vascularization after stroke. Stroke. 2007;38:3032-3039. https://doi.org/10.1161/strokeaha.107.488445
  49. Sondell M, Sundler F, Kanje M. Vascular endothelial growth factor is a neurotrophic factor which stimulates axonal outgrowth through the flk-1 receptor. European Journal of Neuroscience. 2000;12:4243-4254. https://doi.org/10.1046/j.0953-816X.2000.01326.x
  50. Robin AM, Zhang ZG, Wang L, Zhang RL, Katakowski M et al. Stromal cell-derived factor 1alpha mediates neural progenitor cell motility after focal cerebral ischemia. Journal of Cerebral Blood Flow and Metabolism. 2006;26:125-134. https://doi.org/10.1038/sj.jcbfm.9600172 
  51. Lee SR, Kim H, Rogowska J, Zhao B et al. Involvement of matrix metalloproteinase in neuroblast cell migration from the subventricular zone after stroke. The Journal of Neuroscience. 2006;26:3491-3495. https://doi.org/10.1523/JNEUROSCI.4085-05.2006
  52. Liu XS, Zhang ZG, Zhang RL, Gregg S et al. Stroke induces gene profile changes associated with neurogenesis and angiogenesis in adult subventricular zone progenitor cells. Journal of Cerebral Blood Flow and Metabolism. 2007;27:564-574. https://doi.org/10.1038/sj.jcbfm.9600371 
  53. 53.Zhang ZG, Zhang L, Jiang Q, Zhang R et al. VEGF enhances angiogenesis and promotes blood-brain barrier leakage in the ischemic brain. Journal of Clinical Investigations. 2000;106:829-838. https://doi.org/10.1172/jci9369 
  54. Lin TN, Wang CK, Cheung WM, Hsu CY. Induction of angiopoietin and Tie receptor mRNA expression after cerebral ischemia-reperfusion. Journal of Cerebral Blood Flow and Metabolism. 2000;20:387-395. https://doi.org/10.1097/00004647-200002000-00021
  55. Beck H, Acker T, Wiessner C, Allegrini PR, Plate KH. Expression of angiopoietin-1, angiopoietin-2, and tie receptors after middle cerebral artery occlusion in the rat. The American Journal of Pathology. 2000;157:1473-1483. https://doi.org/10.1016/s0002-9440(10)64786-4 
  56. Matsuo R, Ago T, Kamouchi M, Kuroda J, Kuwashiro et al. Clinical significance of plasma VEGF value in ischemic stroke - research for biomarkers in ischemic stroke (REBIOS) study. BMC Neurology. 2013;13(1):32. https://doi.org/10.1186/1471-2377-13-32
  57. Chen S, Huang W, Wang J, Zhang J, Wang W, Zhou M, Gao X, Zhang X. Soluble CD44 and vascular endothelial growth factor levels in patients with acute primary angle closure. Acta Ophthalmologica. 2014;93(4):261-265. https://doi.org/10.1111/aos.12564
  58. Wang X, Sawada T, Sawada O, Saishin Y, Liu P, Ohji M. Serum and Plasma Vascular Endothelial Growth Factor Concentrations Before and After Intravitreal Injection of Aflibercept or Ranibizumab for Age-Related Macular Degeneration. American Journal of Ophthalmology. 2014;158(4): 738-744. https://doi.org/10.1016/j.ajo.2014.06.009
  59. Kirstein M, Moore M, Dudek A. Review of Selected Patents for Cancer Therapy Targeting Tumor Angiogenesis. Recent Patents on Anti-Cancer Drug Discovery. 2006;1(2):153-161. https://doi.org/10.2174/157489206777442269
  60. Huang W, Chen S, Gao X, Yang M, Zhang J, Li X, Wang W, Zhou M, Zhang X, Zhang X. Inflammation-Related Cytokines of Aqueous Humor in Acute Primary Angle-Closure Eyes. Investigative Opthalmology & Visual Science. 2014;55(2):1088. https://doi.org/10.1167/iovs.13-13591
  61. Talwar T, Srivastava MV. Role of vascular endothelial growth factor and other growth factors in post-stroke recovery. Annals of Indian Academy of Neurology. 2014;17(1):1-6. https://doi.org/10.4103/0972-2327.128519
  62. Kubo M, Hata J, Ninomiya T, Matsuda K, Yonemoto K, Nakano T et al. A nonsynonymous SNP in PRKCH (protein kinase C η) increases the risk of cerebral infarction. Nature Genetics. 2007;39(2):212-217. https://doi.org/10.1038/ng1945
  63. Slevin M, Krupinski J, Slowik A, Kumar P, Szczudlik A, Gaffney J. Serial Measurement of Vascular Endothelial Growth Factor and Transforming Growth Factor-1 in Serum of Patients With Acute Ischemic Stroke. Stroke. 2000;31(8):1863-1870. https://doi.org/10.1161/01.STR.31.8.1863

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