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Grusha Ia.O.

NII glaznykh bolezneĭ RAMN, Moskva

Ismailova D.S.

FGBU "NII glaznykh bolezneĭ" RAMN, Moskva;
GBOU VPO "Pervyĭ Moskovskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. I.M. Sechenova" Minzdrava RF

Novikov P.I.

UCH №3 of I.M. Sechenov First Moscow State Medical University, 11, str.5 Rossolimo St., Moscow, Russian Federation, 119021

Kogan E.A.

Nauchnyĭ tsentr akusherstva, ginekologii i perinatologii im. akad. V.I. Kulakova, Moskva

Abramova Yu.V.

Research Institute of Eye Diseases, 11 A,B Rossolimo St., Moscow, Russian Federation, 119021

Bulanov N.M.

I.M. Sechenov First Moscow State Medical University, 2, str. 4 Bol’shaya Pirogovskaya St., Moscow, Russian Federation, 119991

Sherstneva L.V.

I.M. Sechenov First Moscow State Medical University, Ophthalmology Department, 8-2 Trubetskaya St., Moscow, Russian Federation, 119991

Combination therapy of refractory localized granulomatosis with polyangiitis and orbital involvement

Authors:

Grusha Ia.O., Ismailova D.S., Novikov P.I., Kogan E.A., Abramova Yu.V., Bulanov N.M., Sherstneva L.V.

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Journal: Russian Annals of Ophthalmology. 2017;133(2): 86‑91

DOI: 10.17116/oftalma2017133286-90

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To cite this article:

Grusha IaO, Ismailova DS, Novikov PI, Kogan EA, Abramova YuV, Bulanov NM, Sherstneva LV. Combination therapy of refractory localized granulomatosis with polyangiitis and orbital involvement. Russian Annals of Ophthalmology. 2017;133(2):86‑91. (In Russ.)
https://doi.org/10.17116/oftalma2017133286-90

Подписка 2025 (Russian Annals of Ophthalmology)
 
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Granulomatous orbital cellulitis is one of the most common ocular manifestations of granulomatosis with polyangiitis (Wegener’s). The process is often refractory to conventional immunosuppressive therapy and requires a more radical treatment approach. However, surgical experience with this type of patients is limited. There have been just a few reported cases of orbital decompression in such patients and many authors have doubted the appropriateness of the procedure, since it is associated with a high risk of potentially fatal complications. Our experience demonstrates the feasibility and effectiveness of orbital mass removal as to pain relief and exophthalmos reduction.

Keywords:

granulomatosis with polyangiitis
Wegener’s granulomatosis
orbital involvement
orbital decompression
refractory course
optic neuropathy

Authors:

Grusha Ia.O.

NII glaznykh bolezneĭ RAMN, Moskva

Ismailova D.S.

FGBU "NII glaznykh bolezneĭ" RAMN, Moskva;
GBOU VPO "Pervyĭ Moskovskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. I.M. Sechenova" Minzdrava RF

Novikov P.I.

UCH №3 of I.M. Sechenov First Moscow State Medical University, 11, str.5 Rossolimo St., Moscow, Russian Federation, 119021

Kogan E.A.

Nauchnyĭ tsentr akusherstva, ginekologii i perinatologii im. akad. V.I. Kulakova, Moskva

Abramova Yu.V.

Research Institute of Eye Diseases, 11 A,B Rossolimo St., Moscow, Russian Federation, 119021

Bulanov N.M.

I.M. Sechenov First Moscow State Medical University, 2, str. 4 Bol’shaya Pirogovskaya St., Moscow, Russian Federation, 119991

Sherstneva L.V.

I.M. Sechenov First Moscow State Medical University, Ophthalmology Department, 8-2 Trubetskaya St., Moscow, Russian Federation, 119991

List of references:

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  2. Jeanette JC, Falk RJ, Bacon PA, et al. Nomenclature of Vasculitides. 2012 revised International Chapel Hill Consensus Conference. Arthritis & Rheumatism. 2013;65:1-11. doi:10.1002/art.37715
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  12. Beketova TV, Nasonov EL. Current trends in classification and treatment of systemic vasculitis associated with anti-neutrophilic cytoplasmic antibodies: results of 2011. Terapevticheskii arkhiv. 2012;84(5):68-74.(In Russ.)
  13. Pagnoux C, Guillevin L Treatment of granulomatosis with polyangiitis (Wegener's). Expert Rev Clin Immunol. 2015;11(3):339-348. doi:0.1586/1744666X.2015.1008455.
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  19. Julia U. Holle, Christopher Voigt, Marcus Both, Konstanze Holl-Ulrich, Bernhard Nolle, Martin Laudien, Frank Moosig, Wolfgang L. Gross Orbital masses in granulomatosis with polyangiitis are associated with a refractory course and a high burden of local damage. Rheumatology (Oxford). 2013;52(5):875-882. doi:10.1093/rheumatology/kes382
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