The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-4329
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2026
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Grusha Ia.O.

NII glaznykh bolezneĭ RAMN, Moskva

Ismailova D.S.

FGBU "NII glaznykh bolezneĭ" RAMN, Moskva;
GBOU VPO "Pervyĭ Moskovskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. I.M. Sechenova" Minzdrava RF

Novikov P.I.

UCH №3 of I.M. Sechenov First Moscow State Medical University, 11, str.5 Rossolimo St., Moscow, Russian Federation, 119021

Kogan E.A.

Nauchnyĭ tsentr akusherstva, ginekologii i perinatologii im. akad. V.I. Kulakova, Moskva

Abramova Yu.V.

Research Institute of Eye Diseases, 11 A,B Rossolimo St., Moscow, Russian Federation, 119021

Bulanov N.M.

I.M. Sechenov First Moscow State Medical University, 2, str. 4 Bol’shaya Pirogovskaya St., Moscow, Russian Federation, 119991

Sherstneva L.V.

I.M. Sechenov First Moscow State Medical University, Ophthalmology Department, 8-2 Trubetskaya St., Moscow, Russian Federation, 119991

Combination therapy of refractory localized granulomatosis with polyangiitis and orbital involvement

Authors:

Grusha Ia.O., Ismailova D.S., Novikov P.I., Kogan E.A., Abramova Yu.V., Bulanov N.M., Sherstneva L.V.

More about the authors

Journal: Russian Annals of Ophthalmology. 2017;133(2): 86‑91

DOI: 10.17116/oftalma2017133286-90

Read: 948 times

Download PDF (RU)
Contact the author
Table of contents

COMBINATION THERAPY OF REFRACTORY LOCALIZED GRANULOMATOSIS WITH POLYANGIITIS AND ORBITAL INVOLVEMENT
COMBINATION THERAPY OF REFRACTORY LOCALIZED GRANULOMATOSIS WITH POLYANGIITIS AND ORBITAL INVOLVEMENT

To cite this article:

Grusha IaO, Ismailova DS, Novikov PI, Kogan EA, Abramova YuV, Bulanov NM, Sherstneva LV. Combination therapy of refractory localized granulomatosis with polyangiitis and orbital involvement. Russian Annals of Ophthalmology. 2017;133(2):86‑91. (In Russ.)
https://doi.org/10.17116/oftalma2017133286-90

Подписка 2026 Вестник офтальмологии (Russian Annals of Ophthalmology)
МСФ на ЯМ
Использование инфографики авторами научных работ
Close metadata
Recommended articles:
Risk factors of unfa­vorable clinical outcome in orbi­tal granulomatosis with polya­ngiitis. Russian Annals of Ophthalmology. 2026;(1):54-59
Prostate invo­lvement in granulomatosis with polya­ngiitis. Russian Journal of Archive of Pathology. 2025;(3):82-87
Case of ANCA-associated vasculitis debu­ted with clinical picture of severe community-acquired pneumonia. Journal of Respiratory Medi­cine. 2025;(4):41-46
Abstract:

Granulomatous orbital cellulitis is one of the most common ocular manifestations of granulomatosis with polyangiitis (Wegener’s). The process is often refractory to conventional immunosuppressive therapy and requires a more radical treatment approach. However, surgical experience with this type of patients is limited. There have been just a few reported cases of orbital decompression in such patients and many authors have doubted the appropriateness of the procedure, since it is associated with a high risk of potentially fatal complications. Our experience demonstrates the feasibility and effectiveness of orbital mass removal as to pain relief and exophthalmos reduction.

Keywords:

granulomatosis with polyangiitis
Wegener’s granulomatosis
orbital involvement
orbital decompression
refractory course
optic neuropathy

Authors:

Grusha Ia.O.

NII glaznykh bolezneĭ RAMN, Moskva

Ismailova D.S.

FGBU "NII glaznykh bolezneĭ" RAMN, Moskva;
GBOU VPO "Pervyĭ Moskovskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. I.M. Sechenova" Minzdrava RF

Novikov P.I.

UCH №3 of I.M. Sechenov First Moscow State Medical University, 11, str.5 Rossolimo St., Moscow, Russian Federation, 119021

Kogan E.A.

Nauchnyĭ tsentr akusherstva, ginekologii i perinatologii im. akad. V.I. Kulakova, Moskva

Abramova Yu.V.

Research Institute of Eye Diseases, 11 A,B Rossolimo St., Moscow, Russian Federation, 119021

Bulanov N.M.

I.M. Sechenov First Moscow State Medical University, 2, str. 4 Bol’shaya Pirogovskaya St., Moscow, Russian Federation, 119991

Sherstneva L.V.

I.M. Sechenov First Moscow State Medical University, Ophthalmology Department, 8-2 Trubetskaya St., Moscow, Russian Federation, 119991

Close metadata

References:

  1. Grusha YO, Ismailova DS, Novikov PI, Abramova YV. Ophthalmologic manifestation of granulomatosis with polyangiitis (Wegener's granulomatosis). Terapevticheskii arkhiv. 2015;87(12):111-116. (In Russ.) doi:10.17116/terarkh20158712111-116
  2. Jeanette JC, Falk RJ, Bacon PA, et al. Nomenclature of Vasculitides. 2012 revised International Chapel Hill Consensus Conference. Arthritis & Rheumatism. 2013;65:1-11. doi:10.1002/art.37715
  3. Falk RJ, Gross WL, Guillevin L, et al; Granulomatosis with polyangiitis (Wegener’s): an alternative name for Wegener’s granulomatosis. Arthritis & Rheumatism. 2011;63(4):863-864. doi:10.1002/art.30286
  4. Novikov PI, Semenkova EN, Moiseev SV. Modern nomenclature of systemic vasculitis. Klinicheskaya farmakologiya i terapiya. 2013;1:70-74. (In Russ.)
  5. Hoffman GS, Kerr GS, Leavitt RY, Hallahan CW, Lebovics RS, Travis WD, Rottem M, Fauci AS. Wegener granulomatosis: an analysis of 158 patients. Ann Intern Med. 1992;116(6):488-498. doi:10.7326/0003-4819-116-6-488
  6. Novikov PI, Moiseev SV, Kuznetsova EI, Semenkova EN, Mukhin NA. Changes in desease course of the desease and prognosis in granulomatosis with polyangiitis (Wegener’s): 40-years study results. Klinicheskaya farmakologiya i terapiya. 2014;1:32-37. (In Russ.)
  7. Jiang B, Zhao YY, Wei SH Granulomatosis with polyangiitis: the relationship between ocular and nasal disease. Ocular Immunology and Inflammation. 2013;21(2):115-118. doi:10.3109/09273948.2012.747618
  8. Fauci AS, Haynes BF, Katz P, Wolff SM. Wegener’s granulomatosis: prospective clinical and therapeutic experience with 85 patients for 21 years. Ann Intern Med. 1983;98(1):76-85. doi:10.7326/0003-4819-98-1-76
  9. Anderson G, Coles ET, Crane M, Douglas AC, Gibbs AR, Geddes DM, Peel ET, Wood JB. Wegener's granuloma. A series of 265 British cases seen between 1975 and 1910. Q J Med. 1992;83(302):427-438.
  10. Fedorov AA. Morphological basics of scientific research in ophthalmology. Vestnik oftalmologii. 2013;5(129):10-21. (In Russ.)
  11. Moiseev SV, Novikov PI, Meshkov AD, Ivanitskii LV. ANCA-associated vasculitis: disputable aspects of classification, diagnostics and activity evaluation and modern treatment aproaches. Klinicheskaya farmakologiya i terapiya. 2014;1:44-50. (In Russ.)
  12. Beketova TV, Nasonov EL. Current trends in classification and treatment of systemic vasculitis associated with anti-neutrophilic cytoplasmic antibodies: results of 2011. Terapevticheskii arkhiv. 2012;84(5):68-74.(In Russ.)
  13. Pagnoux C, Guillevin L Treatment of granulomatosis with polyangiitis (Wegener's). Expert Rev Clin Immunol. 2015;11(3):339-348. doi:0.1586/1744666X.2015.1008455.
  14. Comarmond C, Cacoub P. Granulomatosis with polyangiitis (Wegener): clinical aspects and treatment. Autoimmun Rev. 2014;13(11):1121-1125. doi:10.1016/j.autrev.2014.08.017
  15. Semenkova EN, Krivosheev OG, Novikov PI, Osipenko VI, Nosova NR, Parfenova SA, Nikiforova NV, Borodin OO. Severe Wegener's granulomatosis successfully treated with rituximab. Terapevticheskii arkhiv. 2010;82(6):53-55. (In Russ.)
  16. Mukhin NA, Semenkova EN, Krivosheev OG, Novikov PI. Rituximab in ANCA-associated systemic vasculitis. Klinicheskaya nefrologiya 2010;2:40-45. (In Russ.)
  17. Recillas-Gispert C, Serna-Ojeda JC, Flores-Suárez LF Rituximab in the treatment of refractory scleritis in patients with granulomatosis with polyangiitis (Wegener's). Graefes Arch Clin Exp Ophthalmol. 2015;253(12):2279-2284. doi:10.1007/s00417-015-3198-5
  18. Calich AL, Puéchal X, Pugnet G, London J, Terrier B, Charles P, Mouthon L, Guillevin L; French Vasculitis Study Group. Rituximab for induction and maintenance therapy in granulomatosis with polyangiitis (Wegener's). Results of a single-center cohort study on 66 patients. J Autoimmun. 2014;50:135-141. doi:10.1016/j.jaut.2014.03.002
  19. Julia U. Holle, Christopher Voigt, Marcus Both, Konstanze Holl-Ulrich, Bernhard Nolle, Martin Laudien, Frank Moosig, Wolfgang L. Gross Orbital masses in granulomatosis with polyangiitis are associated with a refractory course and a high burden of local damage. Rheumatology (Oxford). 2013;52(5):875-882. doi:10.1093/rheumatology/kes382
  20. Bitik B, Kılıç L, Küçükşahin O, Şahin K, Tufan A, Karadağ Ö, Pay S, Ateş A, Ucar M, Tutar H, Karaaslan Y, Yilmaz S, Ertenli AI, Konuk O, Turgay M, Goker B. Retro-orbital granuloma associated with granulomatosis with polyangiitis: a series of nine cases. Rheumatol Int. 2015;35(6):1083-1092. doi:10.1007/s00296-014-3179-8
  21. Thawley SE. Wegener's granulomatosis: unusual indication for orbital decompression. Laryngoscope. 1979;89(1):145-154.
  22. Fishman JM, Slovick A, East CA. Wegener’s granulomatosis of the orbit: two cases requiring endoscopic surgical decompression The Journal of Laryngology & Otology. 2008;122:1257-1259. doi:10.1017/S0022215108001953
  23. Duncker G, Nölle B, Asmus R, Koltze H, Rochels R. Orbital involvement in Wegener's granulomatosis Adv Exp Med Biol. 1993;336:315-317.
  24. Talar-Williams C1, Sneller MC, Langford CA, Smith JA, Cox TA, Robinson MR Orbital socket contracture: a complication of inflammatory orbital disease in patients with Wegener's granulomatosis. Br J Ophthalmol. 2005;89(4):493-497.
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.