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Likhvantseva V.G.

Tsentral'naia klinicheskaia bol'nitsa RAN, Moskva

Safonova T.N.

FGBU "NII glaznykh bolezneĭ" RAMN, Moskva

Kuz'min K.A.

MGU im. M.V. Lomonosova

Primary granulocytic sarcoma of lacrimal gland

Authors:

Likhvantseva V.G., Safonova T.N., Kuz'min K.A.

More about the authors

Journal: Russian Annals of Ophthalmology. 2016;132(3): 82‑89

DOI: 10.17116/oftalma2016132382-89

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Table of contents

PRIMARY GRANULOCYTIC SARCOMA OF LACRIMAL GLAND
PRIMARY GRANULOCYTIC SARCOMA OF LACRIMAL GLAND

To cite this article:

Likhvantseva VG, Safonova TN, Kuz'min KA. Primary granulocytic sarcoma of lacrimal gland. Russian Annals of Ophthalmology. 2016;132(3):82‑89. (In Russ.)
https://doi.org/10.17116/oftalma2016132382-89

Подписка 2026 Вестник офтальмологии (Russian Annals of Ophthalmology)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

The article presents clinical description and instrumental findings (ultrasound examination and multi-slice computed tomography of the orbits) of a rare lacrimal gland tumor, which precedes or concurs with acute myeloblastic leukemia. Due to the low incidence of myeloid (granulocytic) sarcoma, it is not possible to develop a proper algorithm for its diagnosis and treatment. Few descriptions that are available in the literature neither give an idea of the variety of manifestations and the order of organ involvement, nor allow any vital prognosis. Verification of the diagnosis can only be based on immunohistochemical findings of the primary tumor and bone marrow biopsy material. The authors emphasize the importance of combination treatment (radiation therapy of the orbits and chemotherapy) in the prevention of leukemia.

Keywords:

granulocytic sarcoma
lacrimal gland
acute myeloblastic leukemia

Authors:

Likhvantseva V.G.

Tsentral'naia klinicheskaia bol'nitsa RAN, Moskva

Safonova T.N.

FGBU "NII glaznykh bolezneĭ" RAMN, Moskva

Kuz'min K.A.

MGU im. M.V. Lomonosova

Close metadata

References:

  1. Audouin J, Comperat E, Le Tourneau A et al. Myeloid sarcoma: clinical and morphologic criteria useful for diagnosis. Int J Surg Pathol. 2003;11(4):271-282.  doi:10.1177/106689690301100404.
  2. Au WY, Chan AC, Lie AK et al. Recurrent isolated extramedullary relapses as granulocytic sarcomas. Br J Ophthalmol. 1997;81(12):1084-1088. doi:10.1038/sj.bmt.1701043.
  3. Baijal GC, Agarwal ML, Gawande C, Gupta DC. Leukaemic deposits in the orbit. Indian J Ophthalmol. 1979;26:53-55.
  4. Brownstein S, Thelmo W, Olivier A. Granulocytic sarcoma of the orbit. Can J Ophthalmol. 1975;10:174-183.  doi:10.4314/jemp.v1i1.47815.
  5. Bulas RB, Laine FJ, Das Narla L. Bilateral orbital granulocytic sarcoma (chloroma) preceding the blast phase of acute myelogenous leukemia: CT findings. Pediatr Radiol. 1995;25:488-489.  doi:10.1007/bf02019079.
  6. Bullock JD, Goldberg SH, Rakes SM. Orbital tumors in children. Ophthal Plast Reconstr Surg. 1989;5:13-16.  doi:10.1097/00002341-198903000-00002.
  7. Byrd JC, Edenfield J, Shields DJ et al. Extramedullary myeloid cell tumors in acute nonlymphocytic leukemia: a clinical review. J Clin Oncol. 1995;13:1800-1816. doi:10.3109/10428199609067593.
  8. Byrd JC, Weiss RB, Arthur DC et al. Extramedullary leukemia adversely affects hematologic complete remission rate and overall survival in patients with t(8;21)(q22;q22): results from Cancer and Leukemia Group B 8461. J Clin Oncol. 1997;15(2):466-475.  doi:10.3109/10428199609067593.
  9. Cavdar AO, Arcasoy A, Babacan E et al. Ocular granulocytic sarcoma (chloroma) with acute myelomonocytic leukemia in Turkish children. Cancer. 1978;41:1606-1609. doi:10.1002/1097-0142(197804)41:4<1606::aid-cncr2820410451>3.0.co;2-y. 
  10. Cavdar AO, Babacan E, Gozdasoglu S et al. High risk subgroup of acute myelomonocytic leukemia (AMML) with orbito-ocular granulocytic sarcoma (OOGS) in Turkish children. Retrospective analysis of clinical, hematological, ultrastructural and therapeutical findings of thirty-three OOGS. Acta Haematol. 1989;81:80-85.  doi:10.1159/000205531.
  11. Chatterjee BM, Sen NN. Acute myeloid leukaemia with leukaemic deposit in the orbit. Br J Ophthalmol. 1960;44:440-442.  doi:10.1136/bjo.44.7.440. 
  12. Cohen R, Segall HD, Nelson MD Jr et al. Bilateral retroorbital chloromas in a 16-month-old child: CT features. J Comput Assist Tomogr. 1988;12:895-896.
  13. Consul BN, Kulshrestha OP, Mehrotra AS. Bilateral proptosis in acute myeloid leukemia. Br J Ophthalmol. 1967;51:65-67.  doi:10.1136/bjo.51.1.65. 
  14. Davis JL, Parke II DW, Font RL. Granulocytic sarcoma of the orbit: a clinicopathologic study. Ophthalmology. 1985;92:1758-1762. doi:10.1016/s0161-6420(85)34104-0. 
  15. Fellbaum C, Hansmarm ML. Immunohistochemical differential diagnosis of granulocytic sarcomas and malignant lymphomas on formalin-fixed material. Virchows Arch A. 1990;416:351-355.  doi:10.1007/bf01605296.
  16. Gujral S, Bhattarai S, Mohan A et al. Ocular extramedullary myeloid cell tumour in children: an Indian study. J Trop Pediatr. 1999;45:112-115.  doi:10.1093/tropej/45.2.112. 
  17. Hon C, Shek TW, Liang R. Conjunctival chloroma (granulocytic sarcoma). Lancet. 2002;359:2247. doi:10.1016/s0140-6736(02)09294-2. 
  18. Jha BK, Lamba PA. Proptosis as a manifestation of acute myeloid leukaemia. Br J Ophthalmol. 1971;55:844-847.  doi:10.1136/bjo.55.12.844. 
  19. Jordan DR, Noel LP, Carpenter BF. Chloroma. Arch Ophthalmol. 1991;109:734-735.  doi:10.1001/archopht.1991.01080050150047.
  20. Kalmanti M, Anagnostou D, Liarikos S et al. Ocular granulocytic sarcoma in childhood acute myelogenous leukemia. Acta Paediatr Jpn. 1991;33:172-176.  doi:10.1111/j.1442-200x.1991.tb01538.x. 
  21. Lakhkar BN, Banavali S, Philip P. Orbital granulocytic sarcoma in acute myelogenous leukemia. Indian J Pediatr. 2000;67:234-235.  doi:10.1007/bf02723670.
  22. Lee SG, Park TS, Cheong JW et al. Preceding orbital granulocytic sarcoma in an adult patient with acute myelogenous leukemia with t(8;21): a case study and review of the literature. Cancer Genet Cytogenet. 2008;185(1):51-54.  doi:10.1016/j.cancergencyto.2008.04.016. 
  23. Michelson JB, Shields JA, Leonard BC et al. Periorbital chloroma and proptosis in a two-year-old with acute myelogenous leukemia. J Pediatr Ophthalmol Strabismus. 1975;12:255-258.
  24. Mortada A. Orbital lymphoblastomas and acute leukemias in children. Am J Ophthalmol. 1963;55:327-331.  doi:10.1016/0002-9394(63)92691-6. 
  25. Olson JL, May MJ, Stork L et al. Acute megakaryoblastic leukemia in Down syndrome: orbital infiltration. Am J Ophthalmol. 2000;130:128-130.  doi:10.1016/s0002-9394(00)00459-1. 
  26. Puri P, Grover AK. Granulocytic sarcoma of orbit preceding acute myeloid leukaemia: a case report. Eur J Cancer Care (Engl). 1999;8:113-115.  doi:10.1046/j.1365-2354.1999.00140.x. 
  27. Rajantie J, Tarkkanen A, Rapola J et al. Orbital granulocytic sarcoma as a presenting sign in acute myelogenous leukemia. Ophthalmologica. 1984;189:158-161.  doi:10.1159/000309403.
  28. Seal GN, Gupta AK. Orbital deposit in acute myeloid leukaemia. Indian J Ophthalmol. 1973;21:73-77.
  29. Shields JA, Bakewell B, Augsburger JJ et al. Space-occupying orbital masses in children: a review of 250 consecutive biopsies. Ophthalmology. 1986;93:379-384.  doi:10.1016/s0161-6420(86)33731-x. 
  30. Shields JA, Shields CL. Lymphoid tumors and leukemias. In: Atlas of Orbital Tumors. Philadelphia, Pa: Lippincott Williams & Wilkins; 1999:316-340.
  31. Shome DK, Gupta NK, Prajapati NC, et al. Orbital granulocytic sarcomas (myeloid sarcomas) in acute nonlymphocytic leukemia. Cancer. 1992;70:2298-2301. doi:10.1002/1097-0142(19921101)70:9<2298::aid-cncr2820700914>3.0.co;2-i. 
  32. Siernick PH, Serpick AA. Granulocytic sarcoma (chloroma). Blood. 1970;35:361-369.
  33. Singh T, Jayaram G, Gupta AK. Cytologic diagnosis of myeloid sarcoma. Am J Ophthalmol. 1985;99:496-497.  doi:10.1016/0002-9394(85)90034-0. 
  34. Stockl FA, Dolmetsch AM, Saornil MA, Font RL, Burnier MN Jr. Orbital granulocytic sarcoma. Br J Ophthalmol. 1997;81:1084-1088. doi:10.1136/bjo.81.12.1084.
  35. Sundareshan TS, Augustus M, Yasha TC et al. Variant complex translocation 5 (8;15;21) in acute myeloblastic leukemia (M2) associated with bilateral chloroma. Cancer Genet Cytogenet. 1992;64:35-37.  doi:10.1016/0165-4608(92)90319-4. 
  36. Tanigawa M, Tsuda Y, Amemiya T, et al. Orbital tumor in acute myeloid leukemia associated with karyotype 46,XX,t (8;21)(q22;q22): a case report. Ophthalmologica. 1998;212:202-205.  doi:10.1159/000027279.
  37. Uyesugi WY, Wagtabe J, Petermann G. Orbital and facial granulocytic sarcoma (chloroma): a case report. Pediatr Radiol. 2000;30:276-278.  doi:10.1007/s002470050740.
  38. White VA, Rootman J. Orbital pathology: leukemia. In: Albert DM, Jakobiec FA, eds. Principles and Practice of Ophthalmology. Philadelphia, Pa: WB Saunders Co; 1994:2323.
  39. Zimmerman LE, Font RL. Ophthalmologic manifestations of granulocytic sarcoma (myeloid sarcoma or chloroma): the third Pan American Association of Ophthalmology and American Journal of Ophthalmology Lecture. Am J Ophthalmol. 1975;80:975-990.  doi:10.1016/0002-9394(75)90326-8. 
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