Assessing resveratrol effect on ocular blood flow in experiment

Neroyev V.V.; Kiseleva T.N.; Chudin A.V.; Shchipanova A.I.; Ramazanova K.A.

doi:https://doi.org/10.17116/oftalma2016132255-61

Neroyev V.V.

Moscow Helmholtz Research Institute of Eye Diseases, Moscow, Russia

Kiseleva T.N.

Department of Ultrasound of Helmholtz Moscow Research Institute of Eye Diseases, Moscow, Russia

Chudin A.V.

FGBU "Moskovskiĭ NII glaznykh bolezneĭ im. Gel'mgol'tsa" Minzdrava Rossii

Shchipanova A.I.

Moscow Helmholtz Research Institute of Eye Diseases, Ministry of Health of the Russian Federation, 14/19 Sadovaya-Chernogryazskaya St., Moscow, Russian Federation, 105062

Ramazanova K.A.

FGBU "Moskovskiĭ NII glaznykh bolezneĭ im. Gel'mgol'tsa" Minzdrava Rossii

Assessing resveratrol effect on ocular blood flow in experiment

Authors:

Neroyev V.V., Kiseleva T.N., Chudin A.V., Shchipanova A.I., Ramazanova K.A.

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Journal: Russian Annals of Ophthalmology. 2016;132(2): 55‑61

DOI: 10.17116/oftalma2016132255-61

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To cite this article:

Neroyev VV, Kiseleva TN, Chudin AV, Shchipanova AI, Ramazanova KA. Assessing resveratrol effect on ocular blood flow in experiment. Russian Annals of Ophthalmology. 2016;132(2):55‑61. (In Russ.)
https://doi.org/10.17116/oftalma2016132255-61

Подписка 2026 Вестник офтальмологии (Russian Annals of Ophthalmology)

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Abstract:

Aim — to study the effect of resveratrol on ocular blood flow in vivo in healthy rats and those that underwent retinal ischemia/reperfusion. Material and methods. The experimental study was performed on 40 Wistar rats (40 eyes). For ocular blood flow evaluation, color Doppler imaging (CDI), power Doppler (PD), and pulsed-wave spectral Doppler ultrasonography were performed using the Voluson E8 Expert ultrasonic diagnostic system (GE Healthcare). All rats were given resveratrol per os for 2 months of the study. Retinal ischemia/reperfusion injury was induced by a subconjunctival injection of endothelin-1. The control group included 10 intact animals. Results. Signs of ischemic damage of the anterior and posterior eye segments were less pronounced in rats that were given resveratrol during both pre-ischemic (30 days) and post-ischemic (30 days) periods of follow-up. There was also a statistically significant increase in the peak systolic and end diastolic velocity of blood flow as well as a decrease in the resistive index of retrobulbar arteries in those rats that underwent ischemia/reperfusion as compared to the controls. Conclusion. Long-term resveratrol use (2 months) has proved effective in improving ocular blood flow in a rat model of retinal ischemia/reperfusion injury.

Keywords:

ischemia/reperfusion

ocular blood flow

resveratrol

color Doppler imaging

power Doppler

Authors:

Neroyev V.V.

Moscow Helmholtz Research Institute of Eye Diseases, Moscow, Russia

Kiseleva T.N.

Department of Ultrasound of Helmholtz Moscow Research Institute of Eye Diseases, Moscow, Russia

Chudin A.V.

FGBU "Moskovskiĭ NII glaznykh bolezneĭ im. Gel'mgol'tsa" Minzdrava Rossii

Shchipanova A.I.

Moscow Helmholtz Research Institute of Eye Diseases, Ministry of Health of the Russian Federation, 14/19 Sadovaya-Chernogryazskaya St., Moscow, Russian Federation, 105062

Ramazanova K.A.

FGBU "Moskovskiĭ NII glaznykh bolezneĭ im. Gel'mgol'tsa" Minzdrava Rossii

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