Effect of homocysteine on left ventricular structural and functional parameters in patients on programmed hemodialysis

Kharlamova U.V.; Il'icheva O.E.

doi:https://doi.org/

Kharlamova U.V.

Cheliabinskaia gosudarstvennaia meditsinskaia akademiia

Il'icheva O.E.

Cheliabinskaia gosudarstvennaia meditsinskaia akademiia

Effect of homocysteine on left ventricular structural and functional parameters in patients on programmed hemodialysis

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Kharlamova U.V., Il'icheva O.E.

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Journal: Therapeutic Archive. 2013;85(3): 90‑93

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Kharlamova UV, Il'icheva OE. Effect of homocysteine on left ventricular structural and functional parameters in patients on programmed hemodialysis. Therapeutic Archive. 2013;85(3):90‑93. (In Russ.)

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Abstract:

Aim. To determine the effect of plasma homocysteine (Hc) on the structure and function of the left ventricle (LV) in patients treated by programmed hemodialysis. Subjects and methods. 109 patients on programmed hemodialysis were examined. Blood Hc levels were determined and echocardiography was performed in all the patients. Results. In the patients on programmed hemodialysis, Hc concentrations were significantly higher than in apparently healthy individuals; there was a preponderance of mild (49.5%) and moderate (43.1%) hyperhomocysteinemia. LV hypertrophy was diagnosed in 90.8% of the patients. A positive relationship was found between the concentrations of Hc and the E/A ratio (r=0.34; р=0.05), isovolumetric relaxation time (IRT) (r=0.32; р=0.03), and LV mass (LVM) (r=0.3; p=0.05). Multivariate regression analysis indicated that the level of Hc had an independent impact on the E peak (R2=0.3; р=0.05), LV relative wall thickness (RWT) (R2=0.38; р=0.03), and LV IRT (R2=0.3; р=0.06). Conclusion. Elevated plasma Hc levels were found to be related to LVM, LV RWT, LV IRT, E peak, and E/A ratio, suggesting that Hc had an unfavorable effect on the LV structure and function in patients on hemodialysis.

Keywords:

homocysteine

hemodialysis

left ventricular remodeling

Authors:

Kharlamova U.V.

Cheliabinskaia gosudarstvennaia meditsinskaia akademiia

Il'icheva O.E.

Cheliabinskaia gosudarstvennaia meditsinskaia akademiia

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