The immunohistochemical study of the structures of the cardiac conduction system in the case of death from alcoholic cardiomyopathy

Kovalev A.V.; Bogomolov D.V.; Kul'bitskiĭ B.N.; Zavalishina L.É.; Fedulova M.V.

doi:https://doi.org/10.17116/sudmed201558230-31

Kovalev A.V.

Krasnojarskij filial FGBU «Gematologicheskij nauchnyj tsentr» Minzdrava Rossii

Bogomolov D.V.

Federal state budgetary institution «Russian Centre of Forensic Medical Expertise», Moscow, Russia

Kul'bitskiĭ B.N.

FGBU Rossiĭskiĭ tsentr sudebno-meditsinskoĭ ékspertizy Minzdravsotsrazvitiia Rossii

Zavalishina L.É.

FGBU "Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena" Minzdravsotsrazvitiia Rossii

Fedulova M.V.

FBGU"Rossiĭskiĭ tsentr sudebno-meditsinskoĭ ékspertizy" Minzdravsotsrazvitiia Rossii

The immunohistochemical study of the structures of the cardiac conduction system in the case of death from alcoholic cardiomyopathy

Authors:

Kovalev A.V., Bogomolov D.V., Kul'bitskiĭ B.N., Zavalishina L.É., Fedulova M.V.

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Journal: Forensic Medical Expertise. 2015;58(2): 30‑31

DOI: 10.17116/sudmed201558230-31

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To cite this article:

Kovalev AV, Bogomolov DV, Kul'bitskiĭ BN, Zavalishina LÉ, Fedulova MV. The immunohistochemical study of the structures of the cardiac conduction system in the case of death from alcoholic cardiomyopathy. Forensic Medical Expertise. 2015;58(2):30‑31. (In Russ.)
https://doi.org/10.17116/sudmed201558230-31

Подписка 2026 Судебно-медицинская экспертиза (Forensic Medical Expertise)

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Abstract:

The objective of the present study was to study the morphological criteria for toxic cardiopathy with the use of histological and immunohistochemical methods. The results of immunohistochemical studies of the sinoatrial node---???---(SAN) and the working myocardium in the patients presenting with alcoholic cardiomyopathy (ACMP) are presented. It was shown that vimentin expression in the SAN structures and the contractile myocardium is slightly increased whereas the expression of sarcomeric actin is decreased and that of fibrinogen is increased too. The authors put forward an assumption about the role of lesions in the membrane apparatus of the pacemaker cells in the development of arrhythmia characteristic of tanatogenesis associated with alcoholic cardiomyopathy.

Keywords:

chronic alcohol intoxication

alcoholic cardiomyopathy

immunohistochemical studies

tanatogenesis