Dynamics of mandibular density during therapy with zolendronic acid

Nurieva N.S.

South Ural State Medical University

SPIN RSCI: 9776-3982
Scopus AuthorID: 55303881200
ORCID: 0000-0002-5656-2286

Shelegova I.G.

South Ural State Medical University

ORCID: 0000-0002-8381-2535

Fanakin V.A.

South Ural State Medical University

ORCID: 0009-0002-5860-2226

Dynamics of mandibular density during therapy with zolendronic acid

Authors:

Nurieva N.S., Shelegova I.G., Fanakin V.A.

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Journal: Stomatology. 2024;103(4): 33‑36

DOI: 10.17116/stomat202410304133

Downloaded: 14

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To cite this article:

Nurieva NS, Shelegova IG, Fanakin VA. Dynamics of mandibular density during therapy with zolendronic acid. Stomatology. 2024;103(4):33‑36. (In Russ.)
https://doi.org/10.17116/stomat202410304133

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THE AIM OF THE STUDY

Was to investigate the dynamics of mandibular density in cancer patients during therapy with zolendronic acid.

MATERIALS AND METHODS

The study comprised 14 patients who received zolendronic acid at a dosage of 4 mg once every 28 days for bone metastases. In all 14 patients, measurements of mandibular density values on CT scans were performed over time.

RESULTS

Using multiple linear regression analysis, a model was developed to predict the effect of the number of zolendronic acid injections «X₁» on the dynamics of mandibular density «Y». The resulting formula for predicting mandibular density is Y = 5.9 X₁ + 49 HU.

CONCLUSION

The model has limitations due to the study design but still can be used by oncologists and dentists to assess mandibular density in patients taking zolendronic acid.

Keywords:

osteomodifying agents

bisphosphonates

bone metastases

optical density

zolendronic acid

mandible

Authors:

Nurieva N.S.

South Ural State Medical University

SPIN RSCI: 9776-3982
Scopus AuthorID: 55303881200
ORCID: 0000-0002-5656-2286

Shelegova I.G.

South Ural State Medical University

ORCID: 0000-0002-8381-2535

Fanakin V.A.

South Ural State Medical University

ORCID: 0009-0002-5860-2226

Received:

20.12.2023

Accepted:

22.05.2024

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