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Gurin A.N.

Tsentral'nyĭ nauchno-issledovatel'skiĭ institut stomatologii i cheliustno-litsevoĭ khirurgii;
Pervyĭ MGMU im. I.M. Sechenova

Grigoryan A.S.

Federal state budgetary institution «Central Research Institute of Stomatology and Maxillofacial Surgery», Russian Ministry of Health, Moscow, Russia

Fedotov A.Iu.

IMET im. A.A. Baĭkova RAN

Komlev V.S.

Baikov Institute of Metallurgy and Materials Science, Moscow, Russia

The impact of octacalcium phosphate on the dynamics of bone matrix formation in experimental bone defects

Authors:

Gurin A.N., Grigoryan A.S., Fedotov A.Iu., Komlev V.S.

More about the authors

Journal: Stomatology. 2016;95(3): 6‑9

DOI: 10.17116/stomat20169536-9

Views: 859

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Table of contents

THE IMPACT OF OCTACALCIUM PHOSPHATE ON THE DYNAMICS OF BONE MATRIX FORMATION IN EXPERIMENTAL BONE DEFECTS
THE IMPACT OF OCTACALCIUM PHOSPHATE ON THE DYNAMICS OF BONE MATRIX FORMATION IN EXPERIMENTAL BONE DEFECTS

To cite this article:

Gurin AN, Grigoryan AS, Fedotov AIu, Komlev VS. The impact of octacalcium phosphate on the dynamics of bone matrix formation in experimental bone defects. Stomatology. 2016;95(3):6‑9. (In Russ.)
https://doi.org/10.17116/stomat20169536-9

Подписка 2025-2 (Stomatology)
 
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The aim of the study was to assess the interaction of of octacalcium phosphate (OCP) with bone matrix and cells and its impact on the process of bone generation. The survey was conducted on animal model: critical hipbone defect was created in 12 230—250 g Wister rats. The animals were then divided in two groups. In group 1 (6 animals) defect was left to heal under blood clot and in group 2 (6 animals) it was filled with OCP. Three animals with no defect served as a control group. It was showed significant (p<0.05) increase of the area of the newly formed bone tissue and its direct correlation with duration of observation.

Keywords:

bone
biomaterial
OCP
calcium phosphate
osteoinductivity

Authors:

Gurin A.N.

Tsentral'nyĭ nauchno-issledovatel'skiĭ institut stomatologii i cheliustno-litsevoĭ khirurgii;
Pervyĭ MGMU im. I.M. Sechenova

Grigoryan A.S.

Federal state budgetary institution «Central Research Institute of Stomatology and Maxillofacial Surgery», Russian Ministry of Health, Moscow, Russia

Fedotov A.Iu.

IMET im. A.A. Baĭkova RAN

Komlev V.S.

Baikov Institute of Metallurgy and Materials Science, Moscow, Russia

List of references:

  1. Gurin A.N., Komlev V.S., Fadeeva I.V., Barinov S.M. Oktakal'tsii fosfat — prekursor biologicheskoi mineralizatsii, perspektivnyi osteoplasticheskii material. Stomatologiya. 2010;4:65. http://alexgurin.ru/data/articles/2010/Octacalcium_Phosphate_prekursor_biologicheskoy_mineralizazii,_perspektivniy_osteoplasticheskiy_material.pdf
  2. Gurin A.N., Petrovich Yu.A., Komlev V.S., Fadeeva I.V., Barinov S.M. Oktakal'tsii fosfat. Metastabil'naya faza mineralizatsii biologicheskikh apatitov. Rossiiskii stomatologicheskii zhurnal. 2012(3). http://alexgurin.ru/data/articles/2012/Oktakalziy_fosfat._Metastabilnaya_faza_minerazizazii_biologicheskih_apatitov.pdf
  3. Anada T, Kumagai T, Honda Y et al. Dose-dependent osteogenic effect of octacalcium phosphate on mouse bone marrow stromal cells. Tissue engineering. Part A. 2008;14(6):965-978. doi:10.1089/tea.2007.0339.
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  10. Komlev VS, Barinov SM, Bozo, II et al. Bioceramics composed of octacalcium phosphate demonstrate enhanced biological behavior. ACS Appl Mater Interfaces. 2014;6(19):16610-16620. doi:10.1021/am502583p.
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