The article summarizes innovative activity in Omsk State Medical University (OSMU) and contains the review of innovative developments of staff of dental faculty of OSMU (a line of gels for caries prevetion, the DENTEST diagnostic unit, technology of tooth shape modular restoration, personified therapy of patients with periodontal disease, caries diagnosis and periodontontal disease prognosis software, a set of the training materials on esthetic modeling of teeth, personification of clinical approaches in oral bioaesthetic rehabilitation, etc.). The analysis of the factors stimulating and complicating innovative detail in medical school, problems of introduction of medical innovations, lack of system of an assessment of medical technologies in Russia, regulations of the organization of innovative activity in medical schools is carried out, the prospects of their solution connected with decision-making at the state level are formulated.