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Barinov S.V.

Omsk State Medical University

Kadtsyna T.V.

Omsk State Medical University

Tirskaya Yu.I.

Omsk State Medical University

Lazareva O.V.

Omsk State Medical University

Chulovskii Yu.I.

Omsk State Medical University

Zyryanova I.N.

Maternity Hospital No. 2

Zhivotchenko O.Yu.

Maternity Hospital No. 2

Kazakova M.B.

Omsk State Medical University

Orlitskaya A.D.

Omsk State Medical University

Experience in the use of immunochromatographic test of insulin-like growth factor binding protein-1 in the diagnosis of premature rupture of fetal membranes

Authors:

Barinov S.V., Kadtsyna T.V., Tirskaya Yu.I., Lazareva O.V., Chulovskii Yu.I., Zyryanova I.N., Zhivotchenko O.Yu., Kazakova M.B., Orlitskaya A.D.

More about the authors

Journal: Russian Bulletin of Obstetrician-Gynecologist. 2024;24(1): 6‑11

DOI: 10.17116/rosakush2024240116

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Table of contents

EXPERIENCE IN THE USE OF IMMUNOCHROMATOGRAPHIC TEST OF INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN-1 IN THE DIAGNOSIS OF PREMATURE RUPTURE OF FETAL MEMBRANES
EXPERIENCE IN THE USE OF IMMUNOCHROMATOGRAPHIC TEST OF INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN-1 IN THE DIAGNOSIS OF PREMATURE RUPTURE OF FETAL MEMBRANES

To cite this article:

Barinov SV, Kadtsyna TV, Tirskaya YuI, et al. . Experience in the use of immunochromatographic test of insulin-like growth factor binding protein-1 in the diagnosis of premature rupture of fetal membranes. Russian Bulletin of Obstetrician-Gynecologist. 2024;24(1):6‑11. (In Russ.)
https://doi.org/10.17116/rosakush2024240116

Подписка 2025-2 (Russian Bulletin of Obstetrician-Gynecologist)
 
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OBJECTIVE

To evaluate the effectiveness of the test-system based on the determination of insulin-like growth factor binding protein-1 (ILGFBP-1) for the diagnosis of premature rupture of the fetal membranes.

MATERIAL AND METHODS

A retrospective, controlled study was carried out in which 200 patients with gestational age 37—41 weeks were included: 100 pregnant women with premature rupture of fetal membranes (main group), 100 women with timely amniotic fluid shedding in labor (comparison group). In both groups, test systems were used to detect amniotic fluid leakage: nitrazine test (pH determination), ILGFBP-1 determination, and Zeywang test (microscopic examination of vaginal contents). The sensitivity, specificity, prognostic value of positive and negative results were determined.

RESULTS

The best results were demonstrated by the test based on ILGFBP-1 determination (sensitivity 80%, specificity 100%) in comparison with the nitrazine test (sensitivity 71%, specificity 100%) and Zeywang test (sensitivity 55%, specificity 91.9%).

CONCLUSION

Test-systems for diagnostics of premature rupture of fetal membranes on the basis of ILGFBP-1 determination allows to carry out qualitative diagnostics and make a choice of optimal tactics of patient management.

Keywords:

premature rupture of fetal membranes
amniotic fluid
nitrazine test
determination of insulin-like growth factor binding protein-1
Zeiwang test

Authors:

Barinov S.V.

Omsk State Medical University

Kadtsyna T.V.

Omsk State Medical University

Tirskaya Yu.I.

Omsk State Medical University

Lazareva O.V.

Omsk State Medical University

Chulovskii Yu.I.

Omsk State Medical University

Zyryanova I.N.

Maternity Hospital No. 2

Zhivotchenko O.Yu.

Maternity Hospital No. 2

Kazakova M.B.

Omsk State Medical University

Orlitskaya A.D.

Omsk State Medical University

Received:

21.04.2023

Accepted:

16.05.2023

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